ChemicalBook > CAS DataBase List > BTSA 1
BTSA 1
- Product Name
- BTSA 1
- CAS No.
- 314761-14-3
- Chemical Name
- BTSA 1
- Synonyms
- BTSA 1;CS-2853;BTSA 1;BTSA-1;BTSA1 >=98% (HPLC);5-Phenyl-2-(4-phenyl-thiazol-2-yl)-4-(thiazol-2-yl-hydrazono)-2,4-dihydro-pyrazol-3-one;1H-Pyrazole-4,5-dione, 3-phenyl-1-(4-phenyl-2-thiazolyl)-, 4-[2-(2-thiazolyl)hydrazone];5-Phenyl-2-(4-phenylthiazol-2-yl)-4-(2-(thiazol-2-yl)hydrazono)-2,4-dihydro-3H-pyrazol-3-one;inhibit,FITC-BIM,caspase-3/7,translocation,Bcl-2 Family,viability,Inhibitor,BTSA1,mitochondrial,pharmacologically,BAX,AML,BTSA 1,BTSA-1,SAHBA2,Apoptosis
- CBNumber
- CB03374627
- Molecular Formula
- C21H14N6OS2
- Formula Weight
- 430.51
- MOL File
- 314761-14-3.mol
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BTSA 1 Property
- Boiling point:
- 625.2±48.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:53.0(Max Conc. mg/mL);123.11(Max Conc. mM)
- pka
- 6.52±0.40(Predicted)
- form
- Solid
- color
- Brown to reddish brown
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Crysdot
- Product number
- CD31005001
- Product name
- BTSA1
- Purity
- 98%
- Packaging
- 2mg
- Price
- $86
- Updated
- 2021/12/16
Crysdot
- Product number
- CD31005001
- Product name
- BTSA1
- Purity
- 98%
- Packaging
- 5mg
- Price
- $158
- Updated
- 2021/12/16
Crysdot
- Product number
- CD31005001
- Product name
- BTSA1
- Purity
- 98%
- Packaging
- 10mg
- Price
- $313
- Updated
- 2021/12/16
Crysdot
- Product number
- CD31005001
- Product name
- BTSA1
- Purity
- 98%
- Packaging
- 25mg
- Price
- $514
- Updated
- 2021/12/16
DC Chemicals
- Product number
- 012494
- Product name
- BTSA1
- Packaging
- 001
- Price
- $700
- Updated
- 2021/12/16
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BTSA 1 Chemical Properties,Usage,Production
Biological Activity
BTSA1 is a BAX activator that binds to its N-terminal activation site with high affinity and specificity, induces a conformational change in BAX, and causes BAC-mediated apoptosis. It efficiently promotes apoptosis in leukemia cell lines and patient samples without affecting healthy cells.
in vivo
BTSA1 effectively inhibits human acute myeloid leukemia xenografts and enhances host survival without toxic side effects. In mice, it was well tolerated.
target
| Target | Value |
| Bax () |