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FEXOFENADINE HYDROCHLORIDE

Product Name
FEXOFENADINE HYDROCHLORIDE
CAS No.
138452-21-8
Chemical Name
FEXOFENADINE HYDROCHLORIDE
Synonyms
Fexofendine Hcl;FEXOFENADINE HCL;Fexofenadine Hydrochloride (200 mg);terfenidine carboxylate hydrochloride;CARBOXYTERFENADINE,TERFENADINECARBOXYLATE;Fexofenadine Hydrochloride (200 mg)F1E2890.996mg/mg(ai);2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]butyl]phenyl]-2-methylpropanoic acid;2-[4-[1-hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoic acid hydrochloride;(+)-4-(1-HYDROXY-4-(4-HYDROXYDIPHENYLMETHYL)1-PIPERIDINYL)-BUTYL)a,a-(DIMETHYL BENZENE ACETIC ACID HYDROCHLORIDE;ALPHA,ALPHA-DIMETHYL-4-[1-HYDROXY-4-[4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL]BUTYL]-BENZENEACETIC ACID HYDROCHLORIDE
CBNumber
CB0340913
Molecular Formula
C32H40ClNO4
Formula Weight
538.12
MOL File
138452-21-8.mol
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FEXOFENADINE HYDROCHLORIDE Property

storage temp. 
−20°C
solubility 
DMSO: 32 mg/mL, soluble
form 
solid
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Medical Isotopes, Inc.
Product number
10243
Product name
Fexofenadine HCl
Packaging
100mg
Price
$850
Updated
2021/12/16
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FEXOFENADINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

The metabolite of seldane (terfenadine), fexofenadine, was launched in the USA. A histamine H1 receptor antagonist, fexofenadine is more effect than its parent compound without the associated side-effects.

Originator

Sepracor (USA)

Uses

Fexofenadine HCl (Allegra) is a selective, specific H1 antagonist that is structurally related to the butyrophenone tranquilizer haloperidol. It is the active carboxylic acid metabolite of terfenadine (no longer commercially available in the United States). It binds mainly to the peripheral H1 receptors, with minimal crossing of the blood–brain barrier and hence minimal sedative effects. Fexofenadine lacks the cardiotoxic effects of its parent drug, terfenadine. However, it has been associated with increased QT interval, syncope, and ventricular arrhythmia in at least one susceptible patient with preexisting cardiovascular risk. To date, no significant interactions have been demonstrated with fexofenadine when administered concomitantly with azole antifungals or macrolide antibiotics. Indicated for seasonal allergic rhinitis and chronic idiopathic urticaria.

Uses

Anti-histamine

Definition

ChEBI: Fexofenadine hydrochloride is a diarylmethane.

brand name

Allegra

Dosage forms

60 mg PO b.i.d.

FEXOFENADINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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FEXOFENADINE HYDROCHLORIDE Suppliers

Canada 2 China 34 Europe 1 France 1 Germany 2 India 3 South Korea 1 United Kingdom 8 United States 12 Global 64
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
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69
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
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52
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
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79
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
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58
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
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ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3421
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58
Jai Radhe Sales
Tel
+(91)-(79)-26431096/65255722
Fax
+(91)-(79)-26569884
Email
info@jairadhesales.com
Country
India
ProdList
397
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Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
5881
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65
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
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58
Jinan Jason Pharmaceutical Co., Ltd.
Tel
0531-82956131 15069164249
Fax
0531-82956625
Email
jnjspharm@126.com
Country
China
ProdList
1519
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55

138452-21-8, FEXOFENADINE HYDROCHLORIDERelated Search:

FEXOFENADINE HYDROCHLORIDE Terfenadine alpha,alpha-Diphenyl-4-piperidinomethanol Diphenylpiperidin-4-ylmethanol hydrochloride Fexofenadine hydrochloride Acetic acid Fexofenadine 2-Phenylisobutyric acid THIOGLYCOLIC ACID N-BUTYL ESTER 4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE (2RS)-2-(4-BUTYLPHENYL)PROPANOIC ACID Benzeneacetic acid, 4-butyl--alpha--methyl-, (-alpha-S)- (9CI) 4-N-BUTYLPHENETHYL ALCOHOL 4-(TERT-BUTYL)-ALPHA-METHYLBENZYL ALCOHOL (2RS)-2-(4-N-PROPYLPHENYL)PROPANOIC ACID 4-(diphenylmethyl)piperidine 2-(4-PIPERIDYL)-2-PROPANOL PHENYL-PIPERIDIN-4-YL-METHANOL

  • terfenidine carboxylate hydrochloride
  • ALPHA,ALPHA-DIMETHYL-4-[1-HYDROXY-4-[4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL]BUTYL]-BENZENEACETIC ACID HYDROCHLORIDE
  • 2-[4-[1-hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoic acid hydrochloride
  • FEXOFENADINE HCL
  • CARBOXYTERFENADINE,TERFENADINECARBOXYLATE
  • Fexofendine Hcl
  • 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]butyl]phenyl]-2-methylpropanoic acid
  • (+)-4-(1-HYDROXY-4-(4-HYDROXYDIPHENYLMETHYL)1-PIPERIDINYL)-BUTYL)a,a-(DIMETHYL BENZENE ACETIC ACID HYDROCHLORIDE
  • Fexofenadine Hydrochloride (200 mg)
  • Fexofenadine Hydrochloride (200 mg)F1E2890.996mg/mg(ai)
  • Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylMethyl)-1-piperidinyl]butyl]-α,α-diMethyl-, hydrochloride (1:1)
  • 138452-21-8
  • C32H39NO4.HCl