FEXOFENADINE HYDROCHLORIDE
- Product Name
- FEXOFENADINE HYDROCHLORIDE
- CAS No.
- 138452-21-8
- Chemical Name
- FEXOFENADINE HYDROCHLORIDE
- Synonyms
- Fexofendine Hcl;FEXOFENADINE HCL;Fexofenadine Hydrochloride (200 mg);terfenidine carboxylate hydrochloride;CARBOXYTERFENADINE,TERFENADINECARBOXYLATE;Fexofenadine Hydrochloride (200 mg)F1E2890.996mg/mg(ai);2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]butyl]phenyl]-2-methylpropanoic acid;2-[4-[1-hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoic acid hydrochloride;(+)-4-(1-HYDROXY-4-(4-HYDROXYDIPHENYLMETHYL)1-PIPERIDINYL)-BUTYL)a,a-(DIMETHYL BENZENE ACETIC ACID HYDROCHLORIDE;ALPHA,ALPHA-DIMETHYL-4-[1-HYDROXY-4-[4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL]BUTYL]-BENZENEACETIC ACID HYDROCHLORIDE
- CBNumber
- CB0340913
- Molecular Formula
- C32H40ClNO4
- Formula Weight
- 538.12
- MOL File
- 138452-21-8.mol
FEXOFENADINE HYDROCHLORIDE Property
- storage temp.
- −20°C
- solubility
- DMSO: 32 mg/mL, soluble
- form
- solid
- color
- white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 10243
- Product name
- Fexofenadine HCl
- Packaging
- 100mg
- Price
- $850
- Updated
- 2021/12/16
FEXOFENADINE HYDROCHLORIDE Chemical Properties,Usage,Production
Description
The metabolite of seldane (terfenadine), fexofenadine, was launched in the USA. A histamine H1 receptor antagonist, fexofenadine is more effect than its parent compound without the associated side-effects.
Originator
Sepracor (USA)
Uses
Fexofenadine HCl (Allegra) is a selective, specific H1 antagonist that is structurally related to the butyrophenone tranquilizer haloperidol. It is the active carboxylic acid metabolite of terfenadine (no longer commercially available in the United States). It binds mainly to the peripheral H1 receptors, with minimal crossing of the blood–brain barrier and hence minimal sedative effects. Fexofenadine lacks the cardiotoxic effects of its parent drug, terfenadine. However, it has been associated with increased QT interval, syncope, and ventricular arrhythmia in at least one susceptible patient with preexisting cardiovascular risk. To date, no significant interactions have been demonstrated with fexofenadine when administered concomitantly with azole antifungals or macrolide antibiotics. Indicated for seasonal allergic rhinitis and chronic idiopathic urticaria.
Uses
Anti-histamine
Definition
ChEBI: Fexofenadine hydrochloride is a diarylmethane.
brand name
Allegra
Dosage forms
60 mg PO b.i.d.
FEXOFENADINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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