2-CHLOROETHOXY ACETIC ACID
- Product Name
- 2-CHLOROETHOXY ACETIC ACID
- CAS No.
- 14869-41-1
- Chemical Name
- 2-CHLOROETHOXY ACETIC ACID
- Synonyms
- 2-(2-chloroethoxy)acetic acid;CAS_14869-41-1;Chloro-PEG-CH2COOH;Chloro-PEG1-CH2COOH;2-CHLOROETHOXY ACETIC ACID;2-(2-Chloroethoxy)aceticaci;2-(Chloroethoxyl)acetic acid;5-Chloro-3-oxapentanoic acid;2-(2-Chloroethoxy)acetic Acid 2;(2-Chloroethoxy)acetic acid 97%
- CBNumber
- CB0342386
- Molecular Formula
- C4H7ClO3
- Formula Weight
- 138.55
- MOL File
- 14869-41-1.mol
2-CHLOROETHOXY ACETIC ACID Property
- Melting point:
- 32.5-33.0 °C
- Boiling point:
- 130 °C(Press: 3.5 Torr)
- Density
- 1.3296 g/cm3
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- pka
- 3.34±0.10(Predicted)
- form
- liquid
- color
- Yellow
- InChI
- InChI=1S/C4H7ClO3/c5-1-2-8-3-4(6)7/h1-3H2,(H,6,7)
- InChIKey
- MHXJETVNZPUVEN-UHFFFAOYSA-N
- SMILES
- C(O)(=O)COCCCl
Safety
- HS Code
- 2918999090
N-Bromosuccinimide Price
- Product number
- 006248
- Product name
- 2-Chloroethoxyacetic Acid
- Packaging
- 1g
- Price
- $446
- Updated
- 2021/12/16
- Product number
- C365765
- Product name
- 2-ChloroethoxyaceticAcid
- Packaging
- 10g
- Price
- $1110
- Updated
- 2021/12/16
- Product number
- 39349
- Product name
- 2-ChloroethoxyaceticAcid
- Packaging
- 10g
- Price
- $1460
- Updated
- 2021/12/16
- Product number
- OR301184
- Product name
- (2-Chloroethoxy)aceticacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $372
- Updated
- 2021/12/16
- Product number
- 34873
- Product name
- 2-(2-Chloroethoxy)aceticacid
- Packaging
- 1g
- Price
- $430
- Updated
- 2021/12/16
2-CHLOROETHOXY ACETIC ACID Chemical Properties,Usage,Production
Chemical Properties
Light Yellow Oil
Uses
A metabolite of Bis(2-chloroethyl) Ether.
Synthesis
628-89-7
14869-41-1
The general procedure for the synthesis of 2-(2-chloroethoxy)acetic acid from 2-chloroethoxyethanol was as follows: ethylene glycol mono-2-chloroethyl ether (10 g, 0.08 mol) was mixed with a 30% aqueous hydrogen peroxide solution (22.8 g, 0.2 mol), followed by the addition of sodium sulfate dihydrate (0.53 g, 1.6 mmol) and tri-octylmethyl ammonium sulfate (0.75 g, 1.6 mmol). The reaction mixture was stirred at 90°C for 4 hours. Upon completion of the reaction, the reaction was quenched by the addition of aqueous sodium thiosulfate, and then the mixture was extracted with ethyl acetate (50 mL). The organic layers were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give an oily residue (9 g). The residue was diluted with ether and filtered to remove insoluble impurities. The filtrate was extracted by partitioning with the addition of aqueous sodium bicarbonate. The aqueous layer was washed with ether, acidified to pH 2-3 with dilute hydrochloric acid and extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 2-(2-chloroethoxy)acetic acid crude (2.14 g, 19.3% yield) as an oil.IR (neat): ν = 3410 (O-H), 1727 (C=O), 1123, 1044 cm?1 .
References
[1] Tetrahedron Letters, 1996, vol. 37, # 28, p. 4837 - 4840
[2] Heterocycles, 2007, vol. 74, # C, p. 437 - 445
[3] Organic and Biomolecular Chemistry, 2016, vol. 14, # 16, p. 3950 - 3955
[4] Patent: EP1640373, 2006, A1. Location in patent: Page/Page column 21
[5] Patent: WO2008/75152, 2008, A1. Location in patent: Page/Page column 40-41
2-CHLOROETHOXY ACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLOROETHOXY ACETIC ACID manufacturers
- Product
- 2-CHLOROETHOXY ACETIC ACID 14869-41-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-24