ChemicalBook > CAS DataBase List > 1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID

1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID

Product Name
1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID
CAS No.
5274-99-7
Chemical Name
1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID
Synonyms
NSC 15149;TIMTEC-BB SBB003259;N-Benzoylisonipecotic acid;1-(benzoyl)isonipecotic acid;Benzoylpiperidinecarboxylicacid;1-Benzoylpiperidine-4-carbonsSre;N-Bz-4-Piperidinecarboxylic acid;N-Benzoyl-4-piperidinecarboxylic acid;1-BENZOYLPIPERIDINO-4-CARBOXYLIC ACID;1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID
CBNumber
CB0343161
Molecular Formula
C13H15NO3
Formula Weight
233.26
MOL File
5274-99-7.mol
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1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID Property

Melting point:
144-146°C
Boiling point:
438.8±38.0 °C(Predicted)
Density 
1.248±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
4.45±0.20(Predicted)
form 
solid
color 
White
CAS DataBase Reference
5274-99-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
B208753
Product name
1-Benzoylpiperidine-4-carboxylicAcid
Packaging
100mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
4973AE
Product name
1-Benzoylpiperidine-4-carboxylicacid
Packaging
250mg
Price
$63
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB119470
Product name
1-Benzoylpiperidine-4-carboxylic acid
Packaging
500mg
Price
$150
Updated
2021/12/16
Matrix Scientific
Product number
030747
Product name
1-Benzoylpiperidine-4-carboxylic acid
Packaging
500mg
Price
$252
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB119470
Product name
1-Benzoylpiperidine-4-carboxylic acid
Packaging
1g
Price
$255
Updated
2021/12/16
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1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

498-94-2

98-88-4

5274-99-7

4-Piperidine carboxylic acid (129 mg, 1.0 mmol) and benzoyl chloride (140 mg, 1.0 mmol) were mixed in THF (5 mL) in the presence of triethylamine (0.32 mL, 2.5 mmol). The reaction mixture was placed in a microwave reactor and stirred at 70°C, 120 W power for 15 min. Upon completion of the reaction, the reaction mixture was acidified with 1 M HCl (10 mL) and subsequently extracted with dichloromethane (3 x 25 mL). The organic layers were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography using hexane solution of 5% ethyl acetate and hexane solution of 80% ethyl acetate sequentially as eluent to afford 1-benzoylpiperidine-4-carboxylic acid in 94% yield as a white solid with melting point of 136-138°C. 1H NMR (400 MHz, CDCl3) δ 1.71-1.85 (m, 3H), 2.03- 2.06 (m, 1H), 2.59 (tt, 1H, J = 10.4, 4.1 Hz), 3.04-3.12 (m, 2H), 3.72-3.76 (m, 1H), 4.48-4.52 (m, 1H), 7.36-7.44 (m, 5H), 11.16 (br s, 1H).13C NMR (100 MHz. CDCl3) δ 40.4, 41.4, 46.8, 126.7, 128.3, 129.6, 135.3, 170.7, 178.3. HRMS (ESI): C13H14NO3 [M-H]? Calculated value, 232.0973; measured value, 232.0979.

References

[1] Bioorganic Chemistry, 2018, vol. 80, p. 245 - 252
[2] Tetrahedron Letters, 2014, vol. 55, # 12, p. 2037 - 2039
[3] Patent: WO2016/151484, 2016, A1. Location in patent: Paragraph 0327
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 1, p. 119 - 139
[5] Patent: US5948786, 1999, A

1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID Suppliers

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View Lastest Price from 1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID 5274-99-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
1-Benzoyl-4-piperidinecarboxylic acid 5274-99-7
Price
US $8.00/KG
Min. Order
1g
Purity
≥98%
Supply Ability
kg--tons
Release date
2020-03-05

5274-99-7, 1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACIDRelated Search:

1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID 1-BENZOYLPIPERIDINE 1-BENZOYL-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER 1-(4-Chloro-benzoyl)-piperidine-4-carboxylic acid 1-(3,5-dimethoxybenzoyl)piperidine-4-carboxylic acid 1-(3-NITROBENZOYL)-4-PIPERIDINECARBOXYLIC ACID 1-(4-METHOXY-BENZOYL)-PIPERIDINE-4-CARBOXYLIC ACID 1-(3-methoxybenzoyl)piperidine-4-carboxylic acid ETHYL 1-(4-CHLOROBENZOYL)-4-PIPERIDINECARBOXYLATE 1-(2-CHLORO-BENZOYL)-PIPERIDINE-4-CARBOXYLIC ACID 1-(3,4-DIMETHOXY-BENZOYL)-PIPERIDINE-4-CARBOXYLIC ACID 1-(4-nitrobenzoyl)piperidine-4-carboxylic acid 1-(4-FLUORO-BENZOYL)-PIPERIDINE-4-CARBOXYLIC ACID ETHYL 1-(4-METHOXYBENZOYL)-4-PIPERIDINECARBOXYLATE 1-(2-METHYL-BENZOYL)-PIPERIDINE-4-CARBOXYLIC ACID 1-BENZOYLPIPERIDINE-3-CARBOXYLIC ACID 1-(2,4-DIFLUOROBENZOYL)PIPERIDINE-4-CARBOXYLIC ACID METHYL 1-(4-METHOXYBENZOYL)-4-PIPERIDINECARBOXYLATE

  • 1-Benzoylpiperidine-4-carbonsSre
  • 4-piperidinecarboxylic acid, 1-benzoyl-
  • TIMTEC-BB SBB003259
  • 1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID
  • 1-BENZOYLPIPERIDINO-4-CARBOXYLIC ACID
  • Benzoylpiperidinecarboxylicacid
  • 1-Benzoylpiperidine-4-carboxylic acid 98%
  • 1-(benzoyl)isonipecotic acid
  • 1-phenylcarbonylpiperidine-4-carboxylic acid
  • 1-benzoylpiperidine-4-carboxylic acid(SALTDATA: FREE)
  • N-Benzoyl-4-piperidinecarboxylic acid
  • N-Benzoylisonipecotic acid
  • NSC 15149
  • 1-(oxo-phenylmethyl)-4-piperidinecarboxylic acid
  • 1-Benzoyl-4-piperidinecarboxylic acid
  • 1-Benzoylisonipecotic acid, 1-Benzoyl-4-carboxypiperidine
  • 1-Benzoylpiperidine-4-carboxylicacid98%
  • N-Bz-4-Piperidinecarboxylic acid
  • 5274-99-7
  • pharmacetical
  • Piperidine