1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID
- Product Name
- 1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID
- CAS No.
- 5274-99-7
- Chemical Name
- 1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID
- Synonyms
- NSC 15149;TIMTEC-BB SBB003259;N-Benzoylisonipecotic acid;1-(benzoyl)isonipecotic acid;Benzoylpiperidinecarboxylicacid;1-Benzoylpiperidine-4-carbonsSre;N-Bz-4-Piperidinecarboxylic acid;N-Benzoyl-4-piperidinecarboxylic acid;1-BENZOYLPIPERIDINO-4-CARBOXYLIC ACID;1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID
- CBNumber
- CB0343161
- Molecular Formula
- C13H15NO3
- Formula Weight
- 233.26
- MOL File
- 5274-99-7.mol
1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID Property
- Melting point:
- 144-146°C
- Boiling point:
- 438.8±38.0 °C(Predicted)
- Density
- 1.248±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.45±0.20(Predicted)
- form
- solid
- color
- White
- CAS DataBase Reference
- 5274-99-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B208753
- Product name
- 1-Benzoylpiperidine-4-carboxylicAcid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4973AE
- Product name
- 1-Benzoylpiperidine-4-carboxylicacid
- Packaging
- 250mg
- Price
- $63
- Updated
- 2021/12/16
- Product number
- FB119470
- Product name
- 1-Benzoylpiperidine-4-carboxylic acid
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 030747
- Product name
- 1-Benzoylpiperidine-4-carboxylic acid
- Packaging
- 500mg
- Price
- $252
- Updated
- 2021/12/16
- Product number
- FB119470
- Product name
- 1-Benzoylpiperidine-4-carboxylic acid
- Packaging
- 1g
- Price
- $255
- Updated
- 2021/12/16
1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
498-94-2
98-88-4
5274-99-7
4-Piperidine carboxylic acid (129 mg, 1.0 mmol) and benzoyl chloride (140 mg, 1.0 mmol) were mixed in THF (5 mL) in the presence of triethylamine (0.32 mL, 2.5 mmol). The reaction mixture was placed in a microwave reactor and stirred at 70°C, 120 W power for 15 min. Upon completion of the reaction, the reaction mixture was acidified with 1 M HCl (10 mL) and subsequently extracted with dichloromethane (3 x 25 mL). The organic layers were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography using hexane solution of 5% ethyl acetate and hexane solution of 80% ethyl acetate sequentially as eluent to afford 1-benzoylpiperidine-4-carboxylic acid in 94% yield as a white solid with melting point of 136-138°C. 1H NMR (400 MHz, CDCl3) δ 1.71-1.85 (m, 3H), 2.03- 2.06 (m, 1H), 2.59 (tt, 1H, J = 10.4, 4.1 Hz), 3.04-3.12 (m, 2H), 3.72-3.76 (m, 1H), 4.48-4.52 (m, 1H), 7.36-7.44 (m, 5H), 11.16 (br s, 1H).13C NMR (100 MHz. CDCl3) δ 40.4, 41.4, 46.8, 126.7, 128.3, 129.6, 135.3, 170.7, 178.3. HRMS (ESI): C13H14NO3 [M-H]? Calculated value, 232.0973; measured value, 232.0979.
References
[1] Bioorganic Chemistry, 2018, vol. 80, p. 245 - 252
[2] Tetrahedron Letters, 2014, vol. 55, # 12, p. 2037 - 2039
[3] Patent: WO2016/151484, 2016, A1. Location in patent: Paragraph 0327
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 1, p. 119 - 139
[5] Patent: US5948786, 1999, A
1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID Suppliers
- Tel
- --
- Fax
- --
- y.barysheva@ukrorgsynth.com
- Country
- Ukraine
- ProdList
- 6230
- Advantage
- 38
View Lastest Price from 1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID manufacturers
- Product
- 1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID 5274-99-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 1-Benzoyl-4-piperidinecarboxylic acid 5274-99-7
- Price
- US $8.00/KG
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- kg--tons
- Release date
- 2020-03-05