ChemicalBook > CAS DataBase List > 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE

5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE

Product Name
5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE
CAS No.
39974-94-2
Chemical Name
5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE
Synonyms
5-METHOXY-1-METHYL-1H-INDOLE-3-CARBALDEHYDE;AKOS JY2082772;3-Formyl-5-methoxy-1-methylindole;3-Formyl-5-methoxy-1-methyl-1H-indole;5-methoxy-1-methylindole-3-carbaldehyde;5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE;5-METHOXY-1-METHYL-1H-INDOLE-3-CARBALDEHYD;5-Methoxy-1-methyl-1H-indole-3-carboxaldehyde;1H-Indole-3-carboxaldehyde, 5-methoxy-1-methyl-
CBNumber
CB0343873
Molecular Formula
C11H11NO2
Formula Weight
189.21
MOL File
39974-94-2.mol
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5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE Property

Melting point:
133-136°C
Boiling point:
357.9±22.0 °C(Predicted)
Density 
1.14±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
color 
Brown
Water Solubility 
It is insoluble in water.
Sensitive 
Air Sensitive
BRN 
1528827
CAS DataBase Reference
39974-94-2
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36
HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
M223883
Product name
5-Methoxy-1-methyl-1H-indole-3-carbaldehyde
Packaging
100mg
Price
$90
Updated
2021/12/16
SynQuest Laboratories
Product number
4H15-1-41
Product name
5-Methoxy-1-methyl-1H-indole-3-carboxaldehyde
Packaging
1g
Price
$95
Updated
2021/12/16
Matrix Scientific
Product number
038104
Product name
5-Methoxy-1-methyl-1H-indole-3-carbaldehyde
Packaging
500mg
Price
$126
Updated
2021/12/16
SynQuest Laboratories
Product number
4H15-1-41
Product name
5-Methoxy-1-methyl-1H-indole-3-carboxaldehyde
Packaging
5G
Price
$340
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0027238
Product name
5-METHOXY-1-METHYL-1H-INDOLE-3-CARBALDEHYDE
Purity
95.00%
Packaging
500MG
Price
$683.53
Updated
2021/12/16
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5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE Chemical Properties,Usage,Production

Uses

5-Methoxy-1-methylindole-3-carboxaldehyde is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

10601-19-1

74-88-4

39974-94-2

1. 5-methoxyindole-3-carboxaldehyde (300 mg, 1.71 mmol) was added to a stirring solution of sodium hydride suspension (82 mg, 2.05 mmol, 60% dispersed in mineral oil) in DMF (8 mL) in batches under argon protection, a process which needed to be completed within 5 minutes. 2. The reaction mixture was continued to be stirred for 30 minutes, followed by the addition of iodomethane (0.13 mL, 2.05 mmol) and continued stirring for 1 hour. 3. Upon completion of the reaction, 10% sodium bicarbonate solution (40 mL) was added and the mixture was extracted with ethyl acetate (4×). 4. The organic layers were combined, washed sequentially with 10% sodium bicarbonate solution (2×) and saturated sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and concentrated. 5. The crude product was purified by column chromatography (eluent: 50:50 ethyl acetate/hexane) to afford 5-methoxy-1-methylindole-3-carbaldehyde (320 mg, 99%) as a light yellow solid. Rf = 0.35 (50:50 ethyl acetate/hexane); melting point = 130-132°C (literature value: 132-133°C). 1H NMR (CDCl3): δ 9.95 (s, 1H), 7.79 (d, 1H, J = 2.4 Hz), 7.62 (s, 1H), 7.25 (d, 1H, J = 8.8 Hz), 6.96 (dd, 1H, J = 2.4 and 8.9 Hz), 3.90 (s, 3H), 3.85 (s, 3H).

References

[1] Tetrahedron, 2005, vol. 61, # 7, p. 1793 - 1801
[2] Organic Letters, 2013, vol. 15, # 11, p. 2636 - 2639
[3] Patent: US2003/8850, 2003, A1
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 14, p. 6261 - 6276
[5] Chemical Biology and Drug Design, 2015, vol. 86, # 4, p. 731 - 745

5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE manufacturers

Career Henan Chemical Co
Product
5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE 39974-94-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100JKG
Release date
2020-01-14

39974-94-2, 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDERelated Search:

Ethyl 5-acetyloxy-1,2-dimethylindole-3-carboxylate 1-Methylindole 1-Methylindole-3-carboxaldehyde 5-METHOXY-1,2-DIMETHYL-1H-INDOLE-3-CARBALDEHYDE 2-CHLORO-1-(5-METHOXY-1,2-DIMETHYL-1H-INDOL-3-YL)-ETHANONE 5-ETHOXY-1,2-DIMETHYL-1H-INDOLE-3-CARBOXYLIC ACID 5-METHOXY-1,2-DIMETHYL-1H-INDOLE-3-CARBOXYLIC ACID 5-Methoxy-4-methylindole-3-carboxaldehyde 6-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE 1H-Indole-3-carboxylic acid, 6-bromo-1-(2-hydroxy-3-(4-morpholinyl)pro pyl)-5-methoxy-2-methyl-, ethyl ester, monohydrochloride 5-METHOXY-1,2-DIMETHYL-1H-INDOLE-3-CARBOXYLIC ACID ETHYL ESTER 1-BENZYL-5-METHOXY-2-METHYL-1H-INDOLE-3-CARBOXYLIC ACID 6-BROMO-5-METHOXY-1,2-DIMETHYL-1H-INDOLE-3-CARBOXYLIC ACID 1-BENZYL-5-METHOXY-2-METHYL-1H-INDOLE-3-CARBALDEHYDE AKOS BC-1855 5-(BENZYLOXY)-1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1H-INDOLE-3-CARBALDEHYDE 3-ACETYL-1-(4-METHOXYPHENYL)-2-METHYL-1H-INDOL-5-YL 2-FUROATE AKOS BBS-00002569

  • 3-Formyl-5-methoxy-1-methylindole
  • 5-methoxy-1-methylindole-3-carbaldehyde
  • 3-Formyl-5-methoxy-1-methyl-1H-indole
  • 5-Methoxy-1-methyl-1H-indole-3-carboxaldehyde
  • 5-METHOXY-1-METHYL-1H-INDOLE-3-CARBALDEHYD
  • 5-METHOXY-1-METHYL-1H-INDOLE-3-CARBALDEHYDE
  • 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE
  • AKOS JY2082772
  • 1H-Indole-3-carboxaldehyde, 5-methoxy-1-methyl-
  • 39974-94-2