BAM-22P

ChemicalBook > CAS DataBase List > BAM-22P

Product Name: BAM-22P
CAS No.: 76622-26-9
Chemical Name: BAM-22P
Synonyms: BAM22;ADTB1;AP1B1;AP105A;BAM-22P;Peptide E(1-22);BAM 22P acetate;YGGFMRRVGRPEWWMDYQKRYG;BOVINE ADRENAL MEDULLA-22P;BOVINE ADRENAL MEDULLA DOCOSAPEPTIDE
CBNumber: CB0345600
Molecular Formula: C130H184N38O31S2
Formula Weight: 2839.22
MOL File: 76622-26-9.mol

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BAM-22P Property

Density: 1.50±0.1 g/cm3(Predicted)
RTECS: SC6200500
storage temp.: -15°C
solubility: Soluble to 1 mg/ml in H2O
form: Lyophilized solid
Water Solubility: Soluble to 1 mg/ml in water

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J66217
Product name: BAM-22P
Packaging: 1mg
Price: $254
Updated: 2021/12/16

Usbiological

Product number: B2583
Product name: Bovine Adrenal Medulla 22P
Packaging: 1mg
Price: $531
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB73216
Product name: BAM-22P
Packaging: 2mg
Price: $561
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB108610
Product name: BAM-22P H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-OH
Packaging: 2mg
Price: $680
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0000644
Product name: BAM-22P
Purity: 95.00%
Packaging: 1MG
Price: $745.72
Updated: 2021/12/16

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BAM-22P Chemical Properties,Usage,Production

Biological Activity

bovine adrenal medulla 22 peptide (bam22p) is a peptide with 22 amino acids which is one of the cleavage products of proenkephalin a, the precursor of leu- and met-enkephalin, in the adrenal medulla, with very potent opiate activity.

in vitro

in the guinea-pig ileum assay, bam-22p has been shown to have typical and extraordinarily potent opioid activities antagonized by naloxone. the potency of bam-22p is 26 times that of met-enkephalin and 22 times that of b hendorphin. ic50 value of bam-22p in this tissue, 1.3 nm, makes it the most potent met-enkephalin relatives that discoveried so far. [1].

in vivo

intrathecal (i.t.) administration of bam22 decreased nocifensive behavior scores, which measured as the sum of flinching and lifting/licking, in the first and second phases of the formalin test. such decrease was partially attenuated by systemic injection of naloxone. [2].

target

Opioid receptor

IC 50

1.3 nm for opiate activity

References

[1] mizuno k, minamino n, kangawa k, matsuo h. a new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (bam-22p) and eicosapeptide (bam-20p) with very potent opiate activity. biochem biophys res commun. 1980 dec 31;97(4):1283-90.
[2] hong y, dai p, jiang j, zeng x. dual effects of intrathecal bam22 on nociceptive responses in acute and persistent pain--potential function of a novel receptor. br j pharmacol. 2004 feb;141(3):423-30.

BAM-22P Preparation Products And Raw materials

Raw materials

Preparation Products

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76622-26-9, BAM-22PRelated Search:

Met-enkephalinamide cholecystokinin pentapeptide ADRENORPHIN NLE-ARG-PHE AMIDE METHIONINE ENKEPHALINAMIDE ACETATE SALT GASTRIN (14-17) (HUMAN) MET-BETA-ALA BAM-22P DES-TYR1-METHIONINE ENKEPHALINAMIDE ACETATE SALT BAM-22P (Bovine Adrenal Medulla peptides), Rabbit anti-Bovine, IF Kit ANTI-BAM-22P BAM-22P (Bovine Adrenal Medulla peptides), Rabbit anti-Bovine, IH BAM-22P (Bovine Adrenal Medulla peptides), Rabbit anti-Bovine BAM-22P (Bovine Adrenal Medulla peptides), Rabbit anti-Bovine, RIA BAM22P Rabbit Polyclonal ([125I]-TYR)-BAM-22P ALA-PRO-GLY-TRP-NH2 ACETATE SALT

TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU-TRP-TRP-MET-ASP-TYR-GLN-LYS-ARG-TYR-GLY

YGGFMRRVGRPEWWMDYQKRYG

BAM22

L-Tyr-Gly-Gly-L-Phe-L-Met-L-Arg-L-Arg-L-Val-Gly-L-Arg-L-Pro-L-Glu-L-Trp-L-Trp-L-Met-L-Asp-L-Tyr-L-Gln-L-Lys-L-Arg-L-Tyr-Gly-OH

Peptide E(1-22)

ADTB1

AP105A

AP1B1

BAM-22P

BOVINE ADRENAL MEDULLA-22P

BOVINE ADRENAL MEDULLA DOCOSAPEPTIDE

H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU-TRP-TRP-MET-ASP-TYR-GLN-LYS-ARG-TYR-GLY-OH

BAM-22P H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-OH

Glycine, L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valylglycyl-L-arginyl-L-prolyl-L-α-glutamyl-L-tryptophyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-arginyl-L-tyrosyl-

BAM 22P acetate

76622-26-9

C130H184N38O31S2

Peptide

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