BAM-22P
- Product Name
- BAM-22P
- CAS No.
- 76622-26-9
- Chemical Name
- BAM-22P
- Synonyms
- BAM22;ADTB1;AP1B1;AP105A;BAM-22P;Peptide E(1-22);BAM 22P acetate;YGGFMRRVGRPEWWMDYQKRYG;BOVINE ADRENAL MEDULLA-22P;BOVINE ADRENAL MEDULLA DOCOSAPEPTIDE
- CBNumber
- CB0345600
- Molecular Formula
- C130H184N38O31S2
- Formula Weight
- 2839.22
- MOL File
- 76622-26-9.mol
BAM-22P Property
- Density
- 1.50±0.1 g/cm3(Predicted)
- RTECS
- SC6200500
- storage temp.
- -15°C
- solubility
- Soluble to 1 mg/ml in H2O
- form
- Lyophilized solid
- Water Solubility
- Soluble to 1 mg/ml in water
N-Bromosuccinimide Price
- Product number
- J66217
- Product name
- BAM-22P
- Packaging
- 1mg
- Price
- $254
- Updated
- 2021/12/16
- Product number
- B2583
- Product name
- Bovine Adrenal Medulla 22P
- Packaging
- 1mg
- Price
- $531
- Updated
- 2021/12/16
- Product number
- FB73216
- Product name
- BAM-22P
- Packaging
- 100ug
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FB73216
- Product name
- BAM-22P
- Packaging
- 250ug
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FB108610
- Product name
- BAM-22P H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-OH
- Packaging
- 250ug
- Price
- $132.5
- Updated
- 2021/12/16
BAM-22P Chemical Properties,Usage,Production
Biological Activity
bovine adrenal medulla 22 peptide (bam22p) is a peptide with 22 amino acids which is one of the cleavage products of proenkephalin a, the precursor of leu- and met-enkephalin, in the adrenal medulla, with very potent opiate activity.
in vitro
in the guinea-pig ileum assay, bam-22p has been shown to have typical and extraordinarily potent opioid activities antagonized by naloxone. the potency of bam-22p is 26 times that of met-enkephalin and 22 times that of b hendorphin. ic50 value of bam-22p in this tissue, 1.3 nm, makes it the most potent met-enkephalin relatives that discoveried so far. [1].
in vivo
intrathecal (i.t.) administration of bam22 decreased nocifensive behavior scores, which measured as the sum of flinching and lifting/licking, in the first and second phases of the formalin test. such decrease was partially attenuated by systemic injection of naloxone. [2].
target
Opioid receptor
IC 50
1.3 nm for opiate activity
References
[1] mizuno k, minamino n, kangawa k, matsuo h. a new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (bam-22p) and eicosapeptide (bam-20p) with very potent opiate activity. biochem biophys res commun. 1980 dec 31;97(4):1283-90.
[2] hong y, dai p, jiang j, zeng x. dual effects of intrathecal bam22 on nociceptive responses in acute and persistent pain--potential function of a novel receptor. br j pharmacol. 2004 feb;141(3):423-30.
BAM-22P Preparation Products And Raw materials
Raw materials
Preparation Products
BAM-22P Suppliers
- Tel
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- Fax
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- sales@chemcube.eu
- Country
- Germany
- ProdList
- 4083
- Advantage
- 34
- Tel
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- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
- Tel
- --
- Fax
- --
- info@biotrend.ch
- Country
- Germany
- ProdList
- 1250
- Advantage
- 62