BENZENESULFONAMIDE-3-BORONIC ACID PINACOL ESTER
- Product Name
- BENZENESULFONAMIDE-3-BORONIC ACID PINACOL ESTER
- CAS No.
- 486422-08-6
- Chemical Name
- BENZENESULFONAMIDE-3-BORONIC ACID PINACOL ESTER
- Synonyms
- 3-Boronobenzenesulfonamide,pinacol ester;3-Sulfamoylphenylboronic Acid Pinacol Ester;BENZENESULFONAMIDE-3-BORONIC ACID PINACOL ESTER;3-aMinosulfonyl-phenylboronic acid pinacol ester;3-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-sulfonamide;Benzenesulfonamide, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborola...;3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonaMide;Benzenesulfonamide, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- CBNumber
- CB0346379
- Molecular Formula
- C12H18BNO4S
- Formula Weight
- 283.15
- MOL File
- 486422-08-6.mol
BENZENESULFONAMIDE-3-BORONIC ACID PINACOL ESTER Property
- Boiling point:
- 447.1±47.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 10.04±0.60(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- HS Code
- 2935909099
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B689298
- Product name
- 3-Boronobenzenesulfonamide,pinacolester
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FB160578
- Product name
- 3-Boronobenzenesulfonamide, pinacol ester
- Packaging
- 50mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- FB160578
- Product name
- 3-Boronobenzenesulfonamide, pinacol ester
- Packaging
- 100mg
- Price
- $66
- Updated
- 2021/12/16
- Product number
- FB160578
- Product name
- 3-Boronobenzenesulfonamide, pinacol ester
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FB160578
- Product name
- 3-Boronobenzenesulfonamide, pinacol ester
- Packaging
- 500mg
- Price
- $160
- Updated
- 2021/12/16
BENZENESULFONAMIDE-3-BORONIC ACID PINACOL ESTER Chemical Properties,Usage,Production
Synthesis
89599-01-9
73183-34-3
486422-08-6
3-Bromobenzenesulfonamide (0.620 g, 2.63 mmol), potassium acetate (KOAc, 1.032 g, 10.52 mmol) and PdCl2(dppf)2 (0.100 g, 0.137 mmol) were used as raw materials, which were dissolved in dioxane (20 mL) under the protection of argon, and argon was blown up for 10 minutes to deoxygenate. Subsequently, bis(pinacolato)diboron (1.000 g, 3.94 mmol) was added to the reaction system, the reaction vessel was sealed, and the reaction was stirred at 110 °C for 24 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered through diatomaceous earth. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, gradient from 4:1 to 1:1) to afford the target product 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide (0.663 g, 89% yield) as a white solid. The product was characterized by NMR (DMSO-d6, HMDSO): δ 8.14 (ddd, J = 2.0, 1.1, 0.5 Hz, 1H), 7.93 (ddd, J = 7.9, 2.0, 1.3 Hz, 1H), 7.85 (td, J = 1.2, 7.4 Hz, 1H), 7.59 (ddd, J = 7.9, 7.4, 0.5 Hz, 1H), 1.32 (s, 12H).LCMS (ESI) m/z: 284.0 [M + H]+.
References
[1] Patent: WO2016/129983, 2016, A1. Location in patent: Page/Page column 35
[2] Patent: US2016/318895, 2016, A1. Location in patent: Paragraph 0339
BENZENESULFONAMIDE-3-BORONIC ACID PINACOL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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