ChemicalBook > CAS DataBase List > TMS

TMS

Product Name
TMS
CAS No.
24144-92-1
Chemical Name
TMS
Synonyms
CS-961;SMB 00388;TMS, >=98%;5'-tetramethoxystilbene;3,5,2’,4’-Tetramethoxystilbene;2,3',4,5'-TETRAMETHOXYSTILBENE;2,4,3',5'-Tetramethoxystilbene;(E)-2,3',4,5'-TETRAMETHOXYSTILBENE;TMS - Trans-2,3',4,5'-tetramethoxystilbene;(E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene
CBNumber
CB0347220
Molecular Formula
C18H20O4
Formula Weight
300.35
MOL File
24144-92-1.mol
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TMS Property

Melting point:
78-79 °C
Boiling point:
459.9±40.0 °C(Predicted)
Density 
1.117±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 400 μg/ml
form 
Powder
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10038
Product name
TMS
Purity
≥98%
Packaging
1mg
Price
$16
Updated
2024/03/01
Cayman Chemical
Product number
10038
Product name
TMS
Purity
≥98%
Packaging
5mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
10038
Product name
TMS
Purity
≥98%
Packaging
10mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
10038
Product name
TMS
Purity
≥98%
Packaging
50mg
Price
$469
Updated
2024/03/01
TRC
Product number
T298900
Product name
2,4,3'',5''-Tetramethoxystilbene
Packaging
1g
Price
$1695
Updated
2021/12/16
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TMS Chemical Properties,Usage,Production

Uses

CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 μg/ml.

Uses

2,4,3'',5''-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells.

Uses

2,4,3',5'-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells.

Definition

ChEBI: 1-[2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene is a stilbenoid.

Biological Activity

Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC 50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro .

TMS Preparation Products And Raw materials

Raw materials

Preparation Products

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TMS Suppliers

Canada 1 China 60 Europe 1 Germany 2 India 2 Japan 1 United Kingdom 1 United States 16 Global 84
Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from TMS manufacturers

Career Henan Chemical Co
Product
2,4,3',5'-tetramethoxystilbene 24144-92-1
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

24144-92-1, TMSRelated Search:

4-NITROSTYRENE TOLUENE-D8, 99 ATOM % D (CONTAINS 1% V/V TMS) N-METHYL-N-TRIMETHYLSILYLHEPTAFLUOROBUTYRAMIDE (TMS REAGENT FOR GC USING FID) 95+% Methanol-d4 DIMETHYL SULFOXIDE-D6 1-TMS-1H-BENZOTRIAZOLE POLY(DIMETHYLSILOXANE-CO-METHYLHYDRO-SIL OXANE), TMS TERM, VISC CA. 260 CST Acetonitrile-d3 Benzene-D6 Tetrakis(trimethylsilyl)silane ((TMS)4Si ) Pyridine-d5, contains 1 v/v% TMS, 99 atom % D, for NMR,Pyridine-d5, with 0.03% TMS, 100.0 atom% D, for NMR Chloroform-d ACETONE-D6 TMS-BA [=N,O-BIS(TRIMETHYLSILYL)ACETAMIDE] 25% IN ACETONITRILE [FOR GAS CHROMATOGRAPHY] N,N-DIMETHYLFORMAMIDE-D7, 99.5 ATOM % D (CONTAINS 1% V/V TMS) 1-(TMS)ETHYNYLCYCLOHEXENE 1-TMS-1H-BENZOTRIAZOLE Cytochrome P450 1B1 Inhibitor, TMS

  • (E)-2,3',4,5'-TETRAMETHOXYSTILBENE
  • 2,3',4,5'-TETRAMETHOXYSTILBENE
  • 1-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXY-BENZENE
  • 1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE
  • 3,5,2’,4’-Tetramethoxystilbene
  • TMS - Trans-2,3',4,5'-tetramethoxystilbene
  • CS-961
  • Benzene, 1-[(1E)-2-(3,5-diMethoxyphenyl)ethenyl]-2,4-diMethoxy-
  • (E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene
  • TMS, >=98%
  • 5'-tetramethoxystilbene
  • SMB 00388
  • 2,4,3',5'-Tetramethoxystilbene
  • 24144-92-1
  • Antitumour