4-METHOXYPYRIDAZINE
- Product Name
- 4-METHOXYPYRIDAZINE
- CAS No.
- 20733-11-3
- Chemical Name
- 4-METHOXYPYRIDAZINE
- Synonyms
- 4-Methoxy-pyridazin;4-METHOXYPYRIDAZINE;Pyridazine, 4-methoxy-;4-methoxypyridazine hydrochloride;4-METHOXYPYRIDAZINE ISO 9001：2015 REACH
- CBNumber
- CB0352006
- Molecular Formula
- C5H6N2O
- Formula Weight
- 110.11
- MOL File
- 20733-11-3.mol
4-METHOXYPYRIDAZINE Property
- Melting point:
- 43-44℃
- Boiling point:
- 244℃
- Density
- 1.102
- Flash point:
- 89℃
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.28±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C5H6N2O/c1-8-5-2-3-6-7-4-5/h2-4H,1H3
- InChIKey
- NSGNREBTEFKPIL-UHFFFAOYSA-N
- SMILES
- C1=NN=CC=C1OC
Safety
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- M336405
- Product name
- 4-Methoxypyridazine
- Packaging
- 100mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- CHM0377923
- Product name
- 4-METHOXYPYRIDAZINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.58
- Updated
- 2021/12/16
- Product number
- 4H56-1-0R9
- Product name
- 4-Methoxypyridazine
- Packaging
- 1g
- Price
- $600
- Updated
- 2021/12/16
- Product number
- 4H56-1-0R9
- Product name
- 4-Methoxypyridazine
- Packaging
- 250mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- Z5489
- Product name
- 4-Methoxypyridazine
- Packaging
- 10g
- Price
- $1319
- Updated
- 2021/12/16
4-METHOXYPYRIDAZINE Chemical Properties,Usage,Production
Uses
4-methoxypyridazine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Uses
To a solution of 3 ,6-dichloro-4- methoxypyridazine (30 g, 167.59 mmol, 1.00 equiv) and ammonium formate (3 1 g, 491.63 mmol, 2.93 equiv) in MeOH (500 mL) was added 10% palladium on carbon (3 g) catalyst. The mixture was stirred under 1 atmosphere of at rt overnight. The catalyst was removed by filtration and the filtrate was concentrated under vacuum. The residue was triturated in 500 mL of DCM MeOH ( 10: 1 ) and the solid material was filtered out. The filtrate was concentrated under vacuum and the residue was purified on a silica gel column eluted with ethyl acetate/petroleum ether (2:1 to 1: 1) to give 1 5 g (81%) of 4-methoxypyridazine as a brown oil. TLC: petroleum ether: ethyl acetate=2: 1 , Rf=0.1 .
Synthesis
70952-62-4
20733-11-3
General procedure for the synthesis of 4-methoxypyridazine from 4-methoxy-3,6-dichloropyridazine: 10% palladium carbon (3 g) catalyst was added to a solution of methanol (500 mL) containing 3,6-dichloro-4-methoxypyridazine (30 g, 167.59 mmol, 1.00 equiv) and ammonium formate (31 g, 491.63 mmol, 2.93 equiv). The reaction mixture was stirred at room temperature and 1 atm overnight. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under vacuum. The concentrated residue was ground in a solvent mixture of dichloromethane and methanol (500 mL, 10:1 v/v) and subsequently filtered to collect the solid. The filtrate was again concentrated under vacuum and the residue was purified by silica gel column chromatography with the eluent being a solvent mixture of ethyl acetate and petroleum ether (the ratio was tapered from 2:1 to 1:1), resulting in 15 g (81% yield) of 4-methoxypyridazine as a brown oil. Thin-layer chromatography (TLC) conditions: the ratio of petroleum ether to ethyl acetate was 2:1, and the Rf value was 0.1.
References
[1] Patent: WO2013/127268, 2013, A1. Location in patent: Page/Page column 99
[2] Helvetica Chimica Acta, 1956, vol. 39, p. 1755,1762
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View Lastest Price from 4-METHOXYPYRIDAZINE manufacturers
- Product
- 4-methoxypyridazine 20733-11-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minGC
- Supply Ability
- 20kgs/month
- Release date
- 2021-11-13
- Product
- 4-METHOXYPYRIDAZINE 20733-11-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-02
- Product
- 4-METHOXYPYRIDAZINE 20733-11-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20tons
- Release date
- 2019-09-05