ChemicalBook > CAS DataBase List > Tetramethylguanidine
Tetramethylguanidine
- Product Name
- Tetramethylguanidine
- CAS No.
- 80-70-6
- Chemical Name
- Tetramethylguanidine
- Synonyms
- TMG;1,1,3,3-TETRAMETHYLGUANIDINE;TETRAMETHYL GUANIDINE;1,1,3,3-Tetramethyl Guanidine (TMG);N,N’-Tetramethylguanidine;N,N-1,1,3,3-TETRAMETHYLGUANIDINE;Guanidine, N,N,N',N'-tetramethyl-;uanidine;TMG)1,1,3,3-TetraMeth;Metformin Impurity 69
- CBNumber
- CB0355799
- Molecular Formula
- C5H13N3
- Formula Weight
- 115.18
- MOL File
- 80-70-6.mol
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Tetramethylguanidine Property
- Melting point:
- -30 °C
- Boiling point:
- 162-163 °C (lit.)
- Density
- 0.916 g/mL at 20 °C (lit.)
- vapor pressure
- 0.2 mm Hg ( 20 °C)
- refractive index
- n20/D 1.469
- Flash point:
- 140 °F
- storage temp.
- Store below +30°C.
- solubility
- Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 15.20±0.70(Predicted)
- form
- Liquid
- color
- APHA: ≤150
- PH
- 12.7 (10g/l, H2O, 25℃)
- Relative polarity
- 5.5
- Odor
- mild ammoniacal odor
- explosive limit
- 1.0-7.5%(V)
- Water Solubility
- miscible
- Sensitive
- Air Sensitive
- BRN
- 969608
- Dielectric constant
- 23.100000000000001
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents, mineral and organic acids, carbon dioxide. Air-sensitive.
- InChIKey
- KYVBNYUBXIEUFW-UHFFFAOYSA-N
- LogP
- -0.49 at 20℃
- CAS DataBase Reference
- 80-70-6(CAS DataBase Reference)
- NIST Chemistry Reference
- N,N,N',N'-Tetramethylguanidine(80-70-6)
- EPA Substance Registry System
- Guanidine, N,N,N',N'-tetramethyl- (80-70-6)
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Safety
- Hazard Codes
- C
- Risk Statements
- 22-34-20/22-10
- Safety Statements
- 26-27-36/37/39-45-16
- RIDADR
- UN 2920 8/PG 2
- WGK Germany
- 1
- F
- 9-23
- Autoignition Temperature
- 222 °C
- Hazard Note
- Harmful/Corrosive
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29252000
- Toxicity
- LD50 orally in Rabbit: 835 mg/kg
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H290May be corrosive to metals
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 8.21897
- Product name
- N,N,N′,N′-Tetramethylguanidine
- Purity
- for synthesis
- Packaging
- 100mL
- Price
- $86.9
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 8.21897
- Product name
- N,N,N′,N′-Tetramethylguanidine
- Purity
- for synthesis
- Packaging
- 250ML
- Price
- $190
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 241768
- Product name
- 1,1,3,3-Tetramethylguanidine
- Purity
- 99%
- Packaging
- 5ml
- Price
- $50.16
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 241768
- Product name
- 1,1,3,3-Tetramethylguanidine
- Purity
- 99%
- Packaging
- 100ml
- Price
- $81.2
- Updated
- 2025/07/31
TCI Chemical
- Product number
- T0148
- Product name
- 1,1,3,3-Tetramethylguanidine
- Purity
- >99.0%(GC)(T)
- Packaging
- 25mL
- Price
- $19
- Updated
- 2025/07/31
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Tetramethylguanidine Chemical Properties,Usage,Production
Chemical Properties
N,N,N',N' -Tetramethylguanidine (TMG) [80-70-6], C5H13N3, Mr 115.18, is a stable, unusually strong base, pKa 13.6 (25 ℃), with a free imino group. It is a colorless to light-yellow liquid, miscible with water and common organic solvents: 0.92 g/cm3 (25 ℃), bp 160 ℃, vapor pressure 0.03 kPa (25℃).
Uses
Tetramethylguanidine (TMG) is used as polyurethane foam catalyst, as accelerator for the syntheses of polysulfured rubber, as a strong base in the photochemical (e.g. couplers) and in the pharmaceutical (e.g. steroids) industries. Product Data Sheet
Uses
Base employed in the preparation of alkyl nitriles from alkyl halides and 3′-alkylthymidines from 3′-nitrothymidines.
Uses
1,1,3,3-Tetaramethylguanidine is used as a strong, non-nucleophilic base for alkylations in organic synthesis. 1,1,3,3-Tetramethylguanidine is an efficient and selective catalyst for the benzoylation of alcohols.
Flammability and Explosibility
Flammable
Synthesis
Prepared from cyanogen chloride and dimethylamine in a 1 : 2 molar ratio, TMG is used as a polyurethane foam catalyst, in the preparation of pigments for color photography, and in steroid synthesis.
Purification Methods
Reflux it over granulated BaO, then fractionally distil it. Protect it from CO2. [Beilstein 4 IV 227.]
Tetramethylguanidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Tetramethylguanidine manufacturers
Hebei Fengjia New Material Co., Ltd
- Product
- Tetramethylguanidine 80-70-6
- Price
- US $5.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-09-13
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- Tetramethylguanidine 80-70-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-12-06
Jinan Finer Chemical Co., Ltd
- Product
- Tetramethylguanidine 80-70-6
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 2000mt/year
- Release date
- 2021-08-31
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