Labeled d8 Desmethyl Clozapine Hydrochloride
- Product Name
- Labeled d8 Desmethyl Clozapine Hydrochloride
- CAS No.
- 1189888-77-4
- Chemical Name
- Labeled d8 Desmethyl Clozapine Hydrochloride
- Synonyms
- D8-N-Desmethyl Clozapine;[2H8]-N-Desmethyl Clozapine;N-Desmethylclozapine-D8 solution;Labeled d8 Desmethyl Clozapine Hydrochloride;N-DESMETHYLCLOZAPINE (D8, 98%) 100 UG/ML IN METHANOL;6-chloro-10-[(2,2,3,3,5,5,6,6-2H?)piperazin-1-yl]-2,9-diazatricyclo[9.4.0.03,?]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
- CBNumber
- CB03567643
- Molecular Formula
- C17H17ClN4
- Formula Weight
- 312.8
- MOL File
- 1189888-77-4.mol
Labeled d8 Desmethyl Clozapine Hydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 5 mg/ml
- form
- A solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 26027
- Product name
- N-Desmethylclozapine-d8
- Packaging
- 500μg
- Price
- $108
- Updated
- 2024/03/01
- Product number
- 26027
- Product name
- N-Desmethylclozapine-d8
- Packaging
- 1mg
- Price
- $171
- Updated
- 2024/03/01
- Product number
- D292002
- Product name
- N-DesmethylClozapine-d8
- Packaging
- 1mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- D292002
- Product name
- N-DesmethylClozapine-d8
- Packaging
- 10mg
- Price
- $1355
- Updated
- 2021/12/16
- Product number
- 6414EM
- Product name
- N-DesmethylClozapine-d8
- Packaging
- 1mg
- Price
- $287
- Updated
- 2021/12/16
Labeled d8 Desmethyl Clozapine Hydrochloride Chemical Properties,Usage,Production
Uses
A major labelled metabolite of clozapine. A potent and selective 5-HT2C serotonin receptor antogonist.
Biological Activity
N-Desmethylclozapine-d8 is intended for use as an internal standard for the quantification of N-desmethylclozapine by GC- or LC-MS. N-Desmethylclozapine is an active metabolite of the atypical antipsychotic clozapine .1 It was originally described as an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50 = 7.1 nM in rat choroid plexus) and later as an inverse agonist using human recombinant receptors.2,3 N-Desmethylclozapine is an antagonist at dopamine D4 receptors, an agonist at δ-opioid receptors, and a partial agonist at dopamine D2 and D3, M1 muscarinic acetylcholine, and 5-HT1A receptors.3,1,4 N-Desmethylclozapine (30 mg/kg) decreases exploratory locomotor activity and increases prepulse inhibiton of the acoustic startle response in mice.5
IC 50
mAChR1; δ Opioid Receptor/DOR
References
1.Burstein, E.S., Ma, J., Wong, S., et al.Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: Identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonistJ. Pharmacol. Exp. Ther.315(3)1278-1287(2005) 2.Kuoppam?ki, M., Syv?lahti, E., and Hietala, J.Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonistsEur. J. Pharmacol.245(2)179-182(1993) 3.Lameh, J., Burstein, E.S., Taylor, E., et al.Pharmacology of N-desmethylclozapinePharmacol. Ther.115(2)223-231(2007) 4.Odagaki, Y., Kinoshita, M., and Ota, T.Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranesJ. Psychopharmacol.30(9)896-912(2016) 5.Maehara, S., Hikichi, H., and Ohta, H.Behavioral effects of N-desmethylclozapine on locomotor activity and sensorimotor gating function in mice-Possible involvement of muscarinic receptorsBrain Res.1418111-119(2011)
Labeled d8 Desmethyl Clozapine Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Labeled d8 Desmethyl Clozapine Hydrochloride Suppliers
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