ChemicalBook > CAS DataBase List > Labeled d8 Desmethyl Clozapine Hydrochloride

Labeled d8 Desmethyl Clozapine Hydrochloride

Product Name
Labeled d8 Desmethyl Clozapine Hydrochloride
CAS No.
1189888-77-4
Chemical Name
Labeled d8 Desmethyl Clozapine Hydrochloride
Synonyms
[2H8]-N-Desmethyl Clozapine;Labeled d8 Desmethyl Clozapine Hydrochloride;N-DESMETHYLCLOZAPINE (D8, 98%) 100 UG/ML IN METHANOL;6-chloro-10-[(2,2,3,3,5,5,6,6-2H?)piperazin-1-yl]-2,9-diazatricyclo[9.4.0.03,?]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
CBNumber
CB03567643
Molecular Formula
C17H17ClN4
Formula Weight
312.8
MOL File
1189888-77-4.mol
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Labeled d8 Desmethyl Clozapine Hydrochloride Property

storage temp. 
Store at -20°C
solubility 
DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 5 mg/ml
form 
A solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26027
Product name
N-Desmethylclozapine-d8
Packaging
500μg
Price
$108
Updated
2024/03/01
Cayman Chemical
Product number
26027
Product name
N-Desmethylclozapine-d8
Packaging
1mg
Price
$171
Updated
2024/03/01
TRC
Product number
D292002
Product name
N-DesmethylClozapine-d8
Packaging
1mg
Price
$175
Updated
2021/12/16
TRC
Product number
D292002
Product name
N-DesmethylClozapine-d8
Packaging
10mg
Price
$1355
Updated
2021/12/16
AK Scientific
Product number
6414EM
Product name
N-DesmethylClozapine-d8
Packaging
1mg
Price
$287
Updated
2021/12/16
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Labeled d8 Desmethyl Clozapine Hydrochloride Chemical Properties,Usage,Production

Uses

A major labelled metabolite of clozapine. A potent and selective 5-HT2C serotonin receptor antogonist.

Biological Activity

N-Desmethylclozapine-d8 is intended for use as an internal standard for the quantification of N-desmethylclozapine by GC- or LC-MS. N-Desmethylclozapine is an active metabolite of the atypical antipsychotic clozapine .1 It was originally described as an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50 = 7.1 nM in rat choroid plexus) and later as an inverse agonist using human recombinant receptors.2,3 N-Desmethylclozapine is an antagonist at dopamine D4 receptors, an agonist at δ-opioid receptors, and a partial agonist at dopamine D2 and D3, M1 muscarinic acetylcholine, and 5-HT1A receptors.3,1,4 N-Desmethylclozapine (30 mg/kg) decreases exploratory locomotor activity and increases prepulse inhibiton of the acoustic startle response in mice.5

References

1.Burstein, E.S., Ma, J., Wong, S., et al.Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: Identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonistJ. Pharmacol. Exp. Ther.315(3)1278-1287(2005) 2.Kuoppam?ki, M., Syv?lahti, E., and Hietala, J.Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonistsEur. J. Pharmacol.245(2)179-182(1993) 3.Lameh, J., Burstein, E.S., Taylor, E., et al.Pharmacology of N-desmethylclozapinePharmacol. Ther.115(2)223-231(2007) 4.Odagaki, Y., Kinoshita, M., and Ota, T.Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranesJ. Psychopharmacol.30(9)896-912(2016) 5.Maehara, S., Hikichi, H., and Ohta, H.Behavioral effects of N-desmethylclozapine on locomotor activity and sensorimotor gating function in mice-Possible involvement of muscarinic receptorsBrain Res.1418111-119(2011)

Labeled d8 Desmethyl Clozapine Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Labeled d8 Desmethyl Clozapine Hydrochloride Suppliers

Artis Biotech Co. Ltd.
Tel
0575-18780151478 18582380095
Fax
0575-89298961
Email
sales@artisbio.com
Country
China
ProdList
2966
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
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Chengdu Novel Biomedical Co., Ltd.
Tel
028-85255396 18302801538
Fax
028-85255396
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cdnovell@163.com
Country
China
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Energy Chemical
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021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44806
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Manhag Testing Technology Co., Ltd
Tel
020-020-3846236 17688849268
Email
2443244976@qq.com
Country
China
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7775
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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LGC Science (Shanghai) Ltd.
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17717235263
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China
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15583
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Shanghai Beiwanta Biotechnology Co., Ltd.
Tel
021-67187366 19901745723
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info@bwtlab.com
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China
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9284
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Henan Vcommend Consultrading Co., Ltd.
Tel
13393721940; 13393721940
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sales@vcommend.com
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China
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10005
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Nanjing Shizhou Biology Technology Co.,Ltd
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17301488900
Fax
025-85560043
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Country
China
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12582
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1189888-77-4, Labeled d8 Desmethyl Clozapine HydrochlorideRelated Search:


  • Labeled d8 Desmethyl Clozapine Hydrochloride
  • N-DESMETHYLCLOZAPINE (D8, 98%) 100 UG/ML IN METHANOL
  • [2H8]-N-Desmethyl Clozapine
  • 6-chloro-10-[(2,2,3,3,5,5,6,6-2H?)piperazin-1-yl]-2,9-diazatricyclo[9.4.0.03,?]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
  • 1189888-77-4