CARBOXY-PTIO

Product Name: CARBOXY-PTIO
CAS No.: 148819-94-7
Chemical Name: CARBOXY-PTIO
Synonyms: CARBOXY-PTIO;Carboxy-PTIO,98%;CARBOXY-PTIO POTASSIUM;CARBOXY-PTIO, POTASSIUM SALT;CarboxyPTIO potassium,Carboxy PTIO potassium;CARBOXY-PTIO POTASSIUM (2-(4-CARBOXYPHEN YL)-4,4,5,5-TETRAMETHYLIM;4-(4,4,5,5-tetramethyl-1,3-dioxidoimidazol-1-ium-2-yl)benzoic acid;2-(4-CARBOXYPHENYL)-4,4,5,5-TETRAMETHYL-IMIDAZOLINE-1-OXYL-3-OXIDE POTASSIUM;Carboxy-PTIO2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide;2-(4-CARBOXYPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE-1-OXYL-3-OXIDE, POTASSIUM SALT
CBNumber: CB0359762
Molecular Formula: C14H16KN2O4*
Formula Weight: 315.39
MOL File: 148819-94-7.mol

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CARBOXY-PTIO Property

Melting point:: 141-143°C
storage temp.: 2-8°C
solubility: H₂O: >20 mg/mL
form: solid
color: blue
biological source: synthetic (organic)
Water Solubility: Soluble in water. Also soluble in ethanol, methanol, DMSO or DMF.
Stability:: Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
CAS DataBase Reference: 148819-94-7(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 2918999090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C221
Product name: Carboxy-PTIO potassium salt
Packaging: 10mg
Price: $172
Updated: 2024/03/01

Alfa Aesar

Product number: J61316
Product name: Carboxy-PTIO potassium salt, 98+%
Packaging: 10mg
Price: $125
Updated: 2024/03/01

Alfa Aesar

Product number: J61316
Product name: Carboxy-PTIO potassium salt, 98+%
Packaging: 50mg
Price: $442
Updated: 2024/03/01

Cayman Chemical

Product number: 81540
Product name: Carboxy-PTIO (potassium salt)
Purity: ≥99%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 81540
Product name: Carboxy-PTIO (potassium salt)
Purity: ≥99%
Packaging: 10mg
Price: $56
Updated: 2024/03/01

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CARBOXY-PTIO Chemical Properties,Usage,Production

Description

A nitric oxide (NO) scavenger.? Carboxy-PTIO (148819-94-7) reacts with NO with 1:1 stoichiometry1 producing NO2–/NO3–.?? In LPS-induced endotoxin shock, carboxy-PTIO reversed hypotension and renal dysfunction and increased survival in a rat model.2 A very useful tool for probing the involvement of NO in physiological processes.3,4

Chemical Properties

blue powder

Uses

A water soluble, stable organic free radical that reacts stoichiometrically with NO. Carboxy-PTIO converts NO to NO2 and does not dramatically affect other NO related metabolites. This scavenger allows for the specific investigation of the effect of NO.

Uses

Carboxy-PTIO is a NO scavenger. It reacts stoichiometrically with NO and can be used for EPR detection of NO.

Uses

Carboxy-PTIO potassium salt has been used to check the generation of hydroxyl radicals or nitric in reaction mixtures to examine the generation of nitric oxide in reaction mixture. It has also been added to neurons to analyse its effect on glucose/oxygen/serum deprivation (GOSD) condition(4)

Definition

ChEBI: Potassium 2-(4-carboxylatophenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide is a potassium salt having 2-(4-carboxylatophenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide as the counterion. It has a role as a radical scavenger and an apoptosis inhibitor. It is a potassium salt and an organic radical. It contains a carboxylato-PTIO.

General Description

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide?(carboxy-PTIO) is mainly considered as a scavenger of nitric oxide?(NO).

Biological Activity

A stable, water-soluble free radical that reacts stoichiometrically with NO. Almost twice as strong an inhibitor as N( ω )-nitroarginine or N-methylarginine.

Biochem/physiol Actions

Carboxy-PTIO can make a quick reaction with nitric oxide?(NO) to produce nitrogen dioxide (NO2). It can be used to prevent hypotension and endotoxic shock, stimulated by lipopolysaccharide in- vivo. Carboxy-PTIO can also block in vitro vascular relaxation, stimulated by NO.

storage

+4°C

References

Akaike et al. (1993), Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction, Biochemistry, 32 827 Yoshida et al. (1994), Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity; Biochem. Biophys. Res. Commun., 202 923 Hada et al. (2019), Nitric Oxide Is Involved in Heavy Ion-Induced Non-Targeted Effects in Human Fibroblasts; Int. J. Mol. Sci., 20 4327 Jin et al. (2020), A novel quinolinylmethyl substituted ethylenediamine compound exerts anti-cancer effects via stimulating the accumulation of reactive oxygen species and NO in hepatocellular carcinoma cells; Eur. J. Pharmacol., 885 173497

CARBOXY-PTIO Preparation Products And Raw materials

Raw materials

Preparation Products

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CARBOXY-PTIO Suppliers

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View Lastest Price from CARBOXY-PTIO manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: CARBOXY-PTIO 148819-94-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

148819-94-7, CARBOXY-PTIORelated Search:

Tigecycline Fruquintinib|HMPL-013 Ibrutinib Volasertib (BI 6727) Imidazole 2-Phenylbenzimidazole-5-sulfonic acid 1,2-Dimethylimidazole CARBOXY-PTIO, SODIUM SALT 2-(4-CARBOXYPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE- 1-OXYL-3-OXIDE, POTASSIUM SALT (CARBOXY-PTIO) CARBOXY-PTIO CARBOXY-PTIO

CARBOXY-PTIO

CARBOXY-PTIO POTASSIUM

CARBOXY-PTIO, POTASSIUM SALT

2-(4-CARBOXYPHENYL)-4,4,5,5-TETRAMETHYL-IMIDAZOLINE-1-OXYL-3-OXIDE POTASSIUM

2-(4-CARBOXYPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE-1-OXYL-3-OXIDE, POTASSIUM SALT

2-(4-CARBOXYPHENYL)-4,5-DIHYDRO-4,4,5,5-TETRAMETHYL-1H-IMIDAZOL-1-YLOXY-3-OXIDE POTASSIUM

2-(4-CARBOXYPHENYL)-4,5-DIHYDRO-4,4,5,5-TETRAMETHYL-1H-IMIDAZOLYL-1-OXY-3-OXIDE, POTASSIUM SALT

2-(4-CARBOXYPHENYL)-4,5-DIHYDRO-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL, POTASSIUM SALT

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt, 2-(4-Carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazol-1-yloxy-3-oxide potassium salt

Carboxy-PTIO,98%

Carboxy-PTIO2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide

CARBOXY-PTIO POTASSIUM (2-(4-CARBOXYPHEN YL)-4,4,5,5-TETRAMETHYLIM

2-(4-Carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazol-1-yloxy-3-oxide potassium salt

1H-Imidazol-1-yloxy, 2-(4-carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-, 3-oxide, potassium salt (1:1)

4-(4,4,5,5-tetramethyl-1,3-dioxidoimidazol-1-ium-2-yl)benzoic acid

CarboxyPTIO potassium,Carboxy PTIO potassium

148819-94-7

C14H16KN2O4

C14H16N2O4K

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Enzyme

Enzyme Inhibitors

Nitric Oxide Synthase

L to O

BioChemical

Biochemicals and Reagents

Nitric Oxide Reagents