ChemicalBook > CAS DataBase List > 2-Chloro-6-methylaniline

2-Chloro-6-methylaniline

Product Name
2-Chloro-6-methylaniline
CAS No.
87-63-8
Chemical Name
2-Chloro-6-methylaniline
Synonyms
6-CHLORO-O-TOLUIDINE;6-CHLORO-2-METHYLANILINE;6COT;NSC 60121;oro-6-methyL;TIMTEC-BB SBB004153;6-chloro-o-toluidin;2-Chloro-6-methylani;6-CHLORO-2-TOLUIDINE;6-ChIoro-o-toluidine
CBNumber
CB0361613
Molecular Formula
C7H8ClN
Formula Weight
141.6
MOL File
87-63-8.mol
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2-Chloro-6-methylaniline Property

Melting point:
10-12 °C(lit.)
Boiling point:
215 °C(lit.)
Density 
1.152 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.576(lit.)
Flash point:
210 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
pka
2.51±0.10(Predicted)
form 
Oil
color 
Clear Colourless to Pale Purple
Water Solubility 
Immiscible
BRN 
774624
InChIKey
WFNLHDJJZSJARK-UHFFFAOYSA-N
CAS DataBase Reference
87-63-8(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 2-chloro-6-methyl-(87-63-8)
EPA Substance Registry System
6-Chloro-2-methylaniline (87-63-8)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-36/37/39
RIDADR 
UN 3429 6.1/PG 3
WGK Germany 
3
RTECS 
XU5100000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H341Suspected of causing genetic defects

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C51008
Product name
2-Chloro-6-methylaniline
Purity
98%
Packaging
1g
Price
$35.4
Updated
2023/01/07
TCI Chemical
Product number
A1959
Product name
2-Chloro-6-methylaniline
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$70
Updated
2024/03/01
TCI Chemical
Product number
A1959
Product name
2-Chloro-6-methylaniline
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$205
Updated
2024/03/01
Alfa Aesar
Product number
L02629
Product name
2-Chloro-6-methylaniline, 98%
Packaging
25g
Price
$315.65
Updated
2024/03/01
Alfa Aesar
Product number
L02629
Product name
2-Chloro-6-methylaniline, 98%
Packaging
1g
Price
$37.1
Updated
2021/12/16
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2-Chloro-6-methylaniline Chemical Properties,Usage,Production

Description

2-chloro-6-methylaniline is an important organic synthesis intermediate widely applied to chemical pharmacy, pesticides, and organic synthesis. In the aspects of chemical pharmacy and pesticides, 2-chloro-6-methylaniline can be used as a reaction starting material to participate in the preparation processes of tyrosine kinase inhibitors dasatinib, indazole derivatives with anti-breast cancer activity, 2-methyl-6-chlorophenyl sulfonylurea derivatives with bacteriostatic activity and the like; in the aspect of organic synthesis, 2-chloro-6-methylaniline can introduce chemical groups such as hydrazine, nitro, cyano, halogen (F, Cl, Br), and the like into an aromatic ring through diazotization reaction, thereby participating in wide chemical reactions.

Chemical Properties

clear yellow to red-brown liquid

Chemical Properties

The chloromethylanilines are colorless or white crystalline solids or liquids, some have a mild fishy odor.

Uses

2-Chloro-6-methylaniline is a substituted aniline used in the preparation of various pharmaceutical compounds. 2-Chloro-6-methylaniline showed inhibition of the polymerization of vinyl acetate.

Preparation

A preparation method of 2-chloro-6-methylaniline takes 3-chloro-5-methyl-4-nitroaniline as a starting material, water as a solvent, and sulfuric acid as a reactant. Eliminates amino groups through diazotization reaction, reduces by hypophosphorous acid to obtain an intermediate, and finally takes iron powder as reducing nitro groups to prepare the 2-chloro-6-methylaniline through a one-pot reaction.

Potential Exposure

Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill birds. It is marketed as pelleted bait for control of bird populations.

Shipping

UN2239 Chlorotoluidines, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3429 Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1- Poisonous materials

Incompatibilities

Incompatible with oxidizers, strong acids; chloroformates, and acid anhydrides, isocyanates, aldehydes forming fire and explosive hazards.

2-Chloro-6-methylaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-6-methylaniline Suppliers

Changzhou Idea-Works Medical Technology Co., Ltd
Tel
0519-83879978
Email
sales@ideaworkspharm.com
Country
China
ProdList
85
Advantage
62
Yangzhou Prince Chemical Co., Ltd
Tel
0514-84248359 13328140016
Email
sales@princechem.com
Country
China
ProdList
99
Advantage
58
Weifu (Shanghai) Pharmaceutical Technology Co., LTD
Tel
021-57609736
Email
info@shanghaiweifu.cn
Country
China
ProdList
232
Advantage
58
Anqing CHICO Pharmaceutical Co., Ltd.
Tel
18013849479 13585175604
Fax
+86-25-52261140
Email
sales@chicopharm.com
Country
China
ProdList
486
Advantage
65
China Synchem Technology Co.,Ltd.
Tel
+86-0552-4929304 +86-18055277008
Fax
+86-552-4928800
Email
sales@cnsynchem.com
Country
China
ProdList
55
Advantage
65
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3576
Advantage
66
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1998
Advantage
65
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View Lastest Price from 2-Chloro-6-methylaniline manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-Chloro-6-methylaniline 87-63-8
Price
US $50.00-1.00/KG
Min. Order
1KG
Purity
99
Supply Ability
g-kg-tons,free sample is available
Release date
2024-01-02
Hebei Duling International Trade Co. LTD
Product
2-Chloro-6-methylaniline, 98% 87-63-8
Price
US $42.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
5000 tons
Release date
2023-02-15
Henan Aochuang Chemical Co.,Ltd.
Product
2-Chloro-6-methylaniline 87-63-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-30

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