ChemicalBook > CAS DataBase List > 2-Chloro-6-methylaniline

2-Chloro-6-methylaniline

Product Name
2-Chloro-6-methylaniline
CAS No.
87-63-8
Chemical Name
2-Chloro-6-methylaniline
Synonyms
6-CHLORO-O-TOLUIDINE;6-CHLORO-2-METHYLANILINE;6COT;NSC 60121;oro-6-methyL;TIMTEC-BB SBB004153;6-chloro-o-toluidin;2-Chloro-6-methylani;6-CHLORO-2-TOLUIDINE;6-ChIoro-o-toluidine
CBNumber
CB0361613
Molecular Formula
C7H8ClN
Formula Weight
141.6
MOL File
87-63-8.mol
More
Less

2-Chloro-6-methylaniline Property

Melting point:
10-12 °C(lit.)
Boiling point:
215 °C(lit.)
Density 
1.152 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.576(lit.)
Flash point:
210 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
pka
2.51±0.10(Predicted)
form 
Oil
color 
Clear Colourless to Pale Purple
Water Solubility 
Immiscible
BRN 
774624
InChIKey
WFNLHDJJZSJARK-UHFFFAOYSA-N
CAS DataBase Reference
87-63-8(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 2-chloro-6-methyl-(87-63-8)
EPA Substance Registry System
6-Chloro-2-methylaniline (87-63-8)
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-36/37/39
RIDADR 
UN 3429 6.1/PG 3
WGK Germany 
3
RTECS 
XU5100000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214300
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H341Suspected of causing genetic defects

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C51008
Product name
2-Chloro-6-methylaniline
Purity
98%
Packaging
1g
Price
$35.4
Updated
2023/01/07
TCI Chemical
Product number
A1959
Product name
2-Chloro-6-methylaniline
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$70
Updated
2024/03/01
TCI Chemical
Product number
A1959
Product name
2-Chloro-6-methylaniline
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$205
Updated
2024/03/01
Alfa Aesar
Product number
L02629
Product name
2-Chloro-6-methylaniline, 98%
Packaging
25g
Price
$315.65
Updated
2024/03/01
Alfa Aesar
Product number
L02629
Product name
2-Chloro-6-methylaniline, 98%
Packaging
1g
Price
$37.1
Updated
2021/12/16
More
Less

2-Chloro-6-methylaniline Chemical Properties,Usage,Production

Description

2-chloro-6-methylaniline is an important organic synthesis intermediate widely applied to chemical pharmacy, pesticides, and organic synthesis. In the aspects of chemical pharmacy and pesticides, 2-chloro-6-methylaniline can be used as a reaction starting material to participate in the preparation processes of tyrosine kinase inhibitors dasatinib, indazole derivatives with anti-breast cancer activity, 2-methyl-6-chlorophenyl sulfonylurea derivatives with bacteriostatic activity and the like; in the aspect of organic synthesis, 2-chloro-6-methylaniline can introduce chemical groups such as hydrazine, nitro, cyano, halogen (F, Cl, Br), and the like into an aromatic ring through diazotization reaction, thereby participating in wide chemical reactions.

Chemical Properties

clear yellow to red-brown liquid

Chemical Properties

The chloromethylanilines are colorless or white crystalline solids or liquids, some have a mild fishy odor.

Uses

2-Chloro-6-methylaniline is a substituted aniline used in the preparation of various pharmaceutical compounds. 2-Chloro-6-methylaniline showed inhibition of the polymerization of vinyl acetate.

Preparation

A preparation method of 2-chloro-6-methylaniline takes 3-chloro-5-methyl-4-nitroaniline as a starting material, water as a solvent, and sulfuric acid as a reactant. Eliminates amino groups through diazotization reaction, reduces by hypophosphorous acid to obtain an intermediate, and finally takes iron powder as reducing nitro groups to prepare the 2-chloro-6-methylaniline through a one-pot reaction.

Potential Exposure

Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill birds. It is marketed as pelleted bait for control of bird populations.

Shipping

UN2239 Chlorotoluidines, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3429 Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1- Poisonous materials

Incompatibilities

Incompatible with oxidizers, strong acids; chloroformates, and acid anhydrides, isocyanates, aldehydes forming fire and explosive hazards.

2-Chloro-6-methylaniline Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-Chloro-6-methylaniline Suppliers

Americas 1 Belgium 1 Canada 1 China 305 Europe 3 France 2 Germany 8 India 12 Japan 1 Slovakia 2 Switzerland 3 United Kingdom 16 United States 51 Global 406
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Panslavia Chemicals
Tel
--
Fax
--
Country
United States
ProdList
121
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
Chemphtec Corporation
Tel
--
Fax
--
Email
fo@chemphtec.com
Country
United States
ProdList
2181
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
Trans World Chemicals, Inc.
Tel
--
Fax
--
Email
info@transworldchem.com
Country
United States
ProdList
397
Advantage
50
Panslavia Chemicals, LLC
Tel
--
Fax
--
Country
United States
ProdList
310
Advantage
50
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
Trans World Chemicals, Inc.
Tel
--
Fax
--
Email
transworldchems@aol.com
Country
United States
ProdList
1591
Advantage
59
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Acros Organics USA
Tel
--
Fax
--
Email
eveleth@fisherchem.com
Country
United States
ProdList
3846
Advantage
81
Aagile Labs Division of Tyger Scientific
Tel
--
Fax
--
Email
tygersci@yahoo.com
Country
United States
ProdList
6568
Advantage
68
Global Pharma Sourcing, LLC
Tel
--
Fax
--
Email
philma@globalphs.com
Country
United States
ProdList
323
Advantage
58
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Aceto Corporation
Tel
--
Fax
--
Email
contact@aceto.com
Country
United States
ProdList
2619
Advantage
75
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
Eastern Chemical Corp.
Tel
--
Fax
--
Email
eastern@u-g.com
Country
United States
ProdList
2786
Advantage
34
Eastar Chemical Corporation
Tel
--
Fax
--
Email
info@eastarchem.com
Country
United States
ProdList
129
Advantage
38
CHEM-IS-TRY, Inc.
Tel
--
Fax
--
Email
sales@chem-is-try.com
Country
United States
ProdList
551
Advantage
56
Ennova MedChem Group Inc., formerly Arch Corporation
Tel
--
Fax
--
Email
sales@ennovamedchem.com
Country
United States
ProdList
1218
Advantage
42
TimTec Corporation
Tel
--
Fax
--
Email
info@timtec.net
Country
United States
ProdList
6891
Advantage
68
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
Crescent Chemical Co., Inc.
Tel
--
Fax
--
Email
sales@creschem.com
Country
United States
ProdList
4597
Advantage
68
More
Less

View Lastest Price from 2-Chloro-6-methylaniline manufacturers

Suzhou Nordica Biopharma CO.,LTD
Product
2-Chloro-6-methylaniline 87-63-8
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
0.99
Supply Ability
5 tons
Release date
2024-11-15
Henan Fengda Chemical Co., Ltd
Product
2-Chloro-6-methylaniline 87-63-8
Price
US $50.00-1.00/KG
Min. Order
1KG
Purity
99
Supply Ability
g-kg-tons,free sample is available
Release date
2024-01-02
Henan Aochuang Chemical Co.,Ltd.
Product
2-Chloro-6-methylaniline 87-63-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-30

87-63-8, 2-Chloro-6-methylanilineRelated Search:

Glycine Betaine N,N-Dimethylaniline o-Toluidine Epichlorohydrin 2-Chloroaniline N-Methylaniline Toluidine Blue O ALTRENOGEST 3,3',5,5'-Tetramethylbenzidine dihydrochloride N,N-Dimethyl-1,4-phenylenediamine 5-chloro-6-(4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)toluene-3-sulphonic acid 4-AMINO-3-CHLORO-5-METHYLBENZONITRILE 2-CHLORO-6-METHYLPHENYL ISOCYANATE 3-Chloro-2-nitrobenzoic acid 3,5-Dichloroanthranilic acid Disperse Violet 28 Chloroacetic acid

  • benzenamine,2-chloro-6-methyl-
  • benzenamine,2-chloro-6-methyl-(6-cot)
  • o-Toluidine, 6-chloro-
  • 2-chloro-6-methylbenzenamine
  • 2-Chloro-6-methyl-phenylamine
  • 2-CHLORO-6-METHYLANINILE
  • BENZENEAMINE,2-CHLORO-6-METHYL-
  • 2-Chloro-6-methylaniline, typically 99%
  • 2-Amino-3-chlorotoluene, 6-Chloro-o-toluidine
  • 2-Chloro-6-methylaniline(6-Chloro-o-toluidine)
  • 2-Chloro-6-methylani
  • NSC 60121
  • 6COT
  • 6-CHLORO-2-METHYLANILINE
  • 6-CHLORO-2-TOLUIDINE
  • 6-CHLORO-O-TOLUIDINE
  • 3-CHLORO-2-AMINOTOLUENE
  • 1-AMINO-2-CHLORO-6-METHYLBENZENE
  • 2-METHYL-6-CHLORO ANILINE
  • 2-AMINO-3-CHLOROTOLUENE
  • 2-CHLORO-6-METHYLANILINE
  • TIMTEC-BB SBB004153
  • 2-chloro-6-methyl-benzenamin
  • 6-ChIoro-o-toluidine
  • 6-chloro-2-methyl-benzenamin
  • 6-chloro-o-toluidin
  • 6-Chloro-o-toluidine (NH2=1)
  • 2-Chloro-6-methylaniline 97%
  • 2-chlro6-methylaniline
  • 2-Chloro-6-methylaniline &gt
  • 2-Chloro-6-methylanilineSolution,1000mg/L,1ml
  • oro-6-methyL
  • DASATINIB - 2-CHLORO-6-METHYLANILINE
  • Dasatinib Impurity W
  • 87-63-8 2-Chloro-6-methylaniline
  • 87-63-8
  • 87-63-7
  • Nitrogen Compounds
  • Organic Building Blocks
  • C7
  • Amines
  • Building Blocks
  • benzene derivative
  • Anilines, Aromatic Amines and Nitro Compounds
  • pharmaceutical