4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide
- Product Name
- 4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide
- CAS No.
- 1216626-17-3
- Chemical Name
- 4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide
- Synonyms
- [2H5]-Amisulpride;Guaiacol Impurity 28;Amisulpride Impurity 27;4-amino-5-(ethanesulfonyl)-N-({1-[(1,1,2,2,2-2H?)ethyl]pyrrolidin-2-yl}methyl)-2-methoxybenzamide;4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide;Amisulpride Hydrochloride D5Q: What is Amisulpride Hydrochloride D5 Q: What is the CAS Number of Amisulpride Hydrochloride D5 Q: What is the storage condition of Amisulpride Hydrochloride D5 Q: What are the applications of Amisulpride Hydrochloride D5
- CBNumber
- CB03677791
- Molecular Formula
- C17H22D5N3O4S
- Formula Weight
- 374.50978889
- MOL File
- 1216626-17-3.mol
4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide Property
- storage temp.
- Store at -20°C
- solubility
- Chloroform: slightly soluble,Methanol: slightly soluble
- form
- A solid
- color
- White to off-white
- Stability:
- Hygroscopic
N-Bromosuccinimide Price
- Product number
- 30075
- Product name
- Amisulpride-d5
- Packaging
- 1mg
- Price
- $287
- Updated
- 2024/03/01
- Product number
- A633252
- Product name
- Amisulpride-d5
- Packaging
- 10mg
- Price
- $1695
- Updated
- 2021/12/16
- Product number
- 8546DF
- Product name
- Amisulpride-d5
- Packaging
- 1mg
- Price
- $403
- Updated
- 2021/12/16
4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide Chemical Properties,Usage,Production
Description
Amisulpride-d5 is intended for use as an internal standard for the quantification of amisulpride by GC- or LC-MS. Amisulpride is a dopamine D2 and D3 receptor antagonist (Kis = 3 and 3.5 nM, respectively). It is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B, 5-HT7, and 5-HT7A (Kis = 13, 11.5, and 135.5 nM, respectively). It is selective for these receptors over a panel of 39 additional receptors, ion channels, and transporters (Kis = >1,000 nM for all). Amisulpride increases 7-OH-DPAT-induced decreases in dopamine and acetylcholine release in electrically stimulated rat striatal slices (EC50s = 2.2 and 1.2 nM, respectively). It increases the levels of dopamine and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum and nucleus accumbens when administered intraperitoneally at a dose of 10 mg/kg. Amisulpride decreases immobility time in the forced swim test in rats, as well as reduces stress-induced decreases in sucrose consumption in a rat model of depression induced by chronic mild stress.
Uses
Labelled Amisulpride (A633250). Amisulpride is a neuroleptic agent, an analogue of Sulpiride (S689145). Amisulpride is used as an antipsychotic. Amisulpride is a dopamine receptor antagonist.
4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide Preparation Products And Raw materials
Raw materials
Preparation Products
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