ChemicalBook > CAS DataBase List > 4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide

4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide

Product Name
4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide
CAS No.
1216626-17-3
Chemical Name
4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide
Synonyms
D5-Amisulpride;[2H5]-Amisulpride;Guaiacol Impurity 28;Amisulpride Impurity 27;Amisulpride-D5 solution;4-amino-5-(ethanesulfonyl)-N-({1-[(1,1,2,2,2-2H?)ethyl]pyrrolidin-2-yl}methyl)-2-methoxybenzamide;4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide;Amisulpride Hydrochloride D5Q: What is Amisulpride Hydrochloride D5 Q: What is the CAS Number of Amisulpride Hydrochloride D5 Q: What is the storage condition of Amisulpride Hydrochloride D5 Q: What are the applications of Amisulpride Hydrochloride D5
CBNumber
CB03677791
Molecular Formula
C17H22D5N3O4S
Formula Weight
374.50978889
MOL File
1216626-17-3.mol
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4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide Property

storage temp. 
Store at -20°C
solubility 
Chloroform: slightly soluble,Methanol: slightly soluble
form 
A solid
color 
White to off-white
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
30075
Product name
Amisulpride-d5
Packaging
1mg
Price
$287
Updated
2024/03/01
TRC
Product number
A633252
Product name
Amisulpride-d5
Packaging
10mg
Price
$1695
Updated
2021/12/16
AK Scientific
Product number
8546DF
Product name
Amisulpride-d5
Packaging
1mg
Price
$403
Updated
2021/12/16
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4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide Chemical Properties,Usage,Production

Description

Amisulpride-d5 is intended for use as an internal standard for the quantification of amisulpride by GC- or LC-MS. Amisulpride is a dopamine D2 and D3 receptor antagonist (Kis = 3 and 3.5 nM, respectively). It is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B, 5-HT7, and 5-HT7A (Kis = 13, 11.5, and 135.5 nM, respectively). It is selective for these receptors over a panel of 39 additional receptors, ion channels, and transporters (Kis = >1,000 nM for all). Amisulpride increases 7-OH-DPAT-induced decreases in dopamine and acetylcholine release in electrically stimulated rat striatal slices (EC50s = 2.2 and 1.2 nM, respectively). It increases the levels of dopamine and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum and nucleus accumbens when administered intraperitoneally at a dose of 10 mg/kg. Amisulpride decreases immobility time in the forced swim test in rats, as well as reduces stress-induced decreases in sucrose consumption in a rat model of depression induced by chronic mild stress.

Uses

Labelled Amisulpride (A633250). Amisulpride is a neuroleptic agent, an analogue of Sulpiride (S689145). Amisulpride is used as an antipsychotic. Amisulpride is a dopamine receptor antagonist.

IC 50

D3 Receptor

References

[1] ATHEIR I ABBAS. Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo.[J]. Psychopharmacology, 2009: 119-128. DOI: 10.1007/s00213-009-1521-8
[2] H SCHOEMAKER. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity.[J]. Journal of Pharmacology and Experimental Therapeutics, 1997, 280 1: 83-97.
[3] M PAPP  J W. Antidepressant-like activity of amisulpride in two animal models of depression.[J]. Journal of Psychopharmacology, 2000, 14 1: 46-52. DOI: 10.1177/026988110001400106

4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide Suppliers

China 35 India 3 United States 3 Global 41
S.Z. PhyStandard Bio-Tech. Co., Ltd.
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0755-4000505016 13380397412
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0755 28094224
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3001272453@qq.com
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China
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Artis Biotech Co. Ltd.
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028-67271278 18628360895
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0575-89298961
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sales@artisbio.com
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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ShangHai Anpel Co, Ltd.
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18501792038 18502138905
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shanpel@anpel.com.cn
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Energy Chemical
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021-58432009 400-005-6266
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1216626-17-3, 4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamideRelated Search:

4-AMino-N-[(1-ethyl-2-pyrrolidinyl)Methyl]-5-(ethylsulfonyl)- 2-MethoxybenzaMide N-Oxide 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-iodo-2-methoxybenzamide N-Des[(1-ethyl-2-pyrrolidinyl)Methyl]-N-(1-ethyl-3-piperidinyl) AMisulpride 2-(Aminomethyl)-1-ethylpyrrolidine Amisulpride [[p-(2-methoxyethyl)phenoxy]methyl]oxirane 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Amisulpride EP Impurity H AMisulpride IMpurity D DesMethyl AMisulpride

  • [2H5]-Amisulpride
  • Amisulpride Impurity 27
  • Amisulpride Hydrochloride D5Q: What is Amisulpride Hydrochloride D5 Q: What is the CAS Number of Amisulpride Hydrochloride D5 Q: What is the storage condition of Amisulpride Hydrochloride D5 Q: What are the applications of Amisulpride Hydrochloride D5
  • 4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide
  • Guaiacol Impurity 28
  • 4-amino-5-(ethanesulfonyl)-N-({1-[(1,1,2,2,2-2H?)ethyl]pyrrolidin-2-yl}methyl)-2-methoxybenzamide
  • Amisulpride-D<sub>5</sub> solution
  • D5-Amisulpride
  • 1216626-17-3