4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid

Product Name: 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid
CAS No.: 71675-87-1
Chemical Name: 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid
Synonyms: 4-AMINO-5-(ETHYLSULFONYL)-2-METHOXYBENZOIC ACID;2-METHOXY-4-AMINO-5-ETHYLSULFONYLBENZOIC ACID;Ami acid;Amidic acid;AMisulpride Acid;4-Amino-5-ethylsulfo...;Amisulpride EP Impurity E;4-Amino-5-(ethylsulfonyl);4-Amino-5-(ethylsulphonyl)-2-methox;4-Amino-5-ethylsulfonyl-2-methoxybenz
CBNumber: CB4763363
Molecular Formula: C10H13NO5S
Formula Weight: 259.28
MOL File: 71675-87-1.mol

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4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Property

Melting point:: 82-85°C
Boiling point:: 529.6±50.0 °C(Predicted)
Density: 1.390±0.06 g/cm3(Predicted)
vapor pressure: 0Pa at 25℃
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 4.09±0.10(Predicted)
color: White to buff coloured powder
Water Solubility: 8.555g/L at 25℃
InChI: InChI=1S/C10H13NO5S/c1-3-17(14,15)9-4-6(10(12)13)8(16-2)5-7(9)11/h4-5H,3,11H2,1-2H3,(H,12,13)
InChIKey: OJVNCXHGGYYOPH-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(S(CC)(=O)=O)=C(N)C=C1OC
LogP: 0.46
CAS DataBase Reference: 71675-87-1(CAS DataBase Reference)

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Safety

HazardClass: IRRITANT
HS Code: 29225090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2615
Product name: 4-Amino-5-(ethylsulfonyl)-2-methoxybenzoic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: A2615
Product name: 4-Amino-5-(ethylsulfonyl)-2-methoxybenzoic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $153
Updated: 2025/07/31

TRC

Product number: M260880
Product name: 2-Methoxy-4-amino-5-ethylsulfonylbenzoicAcid
Packaging: 250mg
Price: $155
Updated: 2021/12/16

Usbiological

Product number: 281778
Product name: 2-Methoxy-4-amino-5-ethylsulfonyl benzoic acid
Packaging: 100g
Price: $460
Updated: 2021/12/16

TRC

Product number: M260880
Product name: 2-Methoxy-4-amino-5-ethylsulfonylbenzoicAcid
Packaging: 100mg
Price: $120
Updated: 2021/12/16

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4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Chemical Properties,Usage,Production

Chemical Properties

Slightly Pink Solid

Uses

An impurity found in amisulpride (A633250). Amisulpride EP Impurity E

Flammability and Explosibility

Not classified

Synthesis

1119455-01-4

71675-87-1

The general procedure for the synthesis of 4-amino-5-(ethylsulfonyl)-2-methoxybenzoic acid using amisulpride impurity 4 as a starting material was as follows: 30% hydrogen peroxide was slowly added to isopropanol (4.84 L) at ambient temperature containing a catalytic amount of sodium tungstate (0.0082 kg) in 4-amino-2-methoxy-5-ethylthiomethyl benzoate (X) (1.21 kg) solution. The reaction mixture was stirred at 40-45 °C for 3-4 hours and subsequently cooled to 5-10 °C. To the reaction mixture, 5% sodium thiosulfate solution (0.06 kg dissolved in 18.15 L of water) was added and stirring was continued for 60 min to produce methyl 2-methoxy-4-amino-5-ethylsulfonylbenzoate (XI) in situ. Subsequently, sodium hydroxide (1.00 kg dissolved in 10 L of water) was added to the reaction mixture, warmed to 60-65 °C and stirred for 2-3 hours. Upon completion of the reaction, the reaction material was cooled and the pH was adjusted to 4.0-4.5 with dilute hydrochloric acid (1:10). the product was isolated by diafiltration in 82% yield and 99% purity.

References

[1] Patent: WO2011/158084, 2011, A1. Location in patent: Page/Page column 12
[2] Patent: WO2011/158084, 2011, A1

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Suppliers

Americas 1 Canada 5 China 297 Europe 3 Germany 2 India 64 Japan 1 Ukraine 1 United Kingdom 9 United States 36 Global 419

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View Lastest Price from 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid 71675-87-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-21

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid 71675-87-1
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-12-10

Hebei Ganmiao New material Technology Co., LTD

Product: 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid 71675-87-1
Price: US $10.00-7.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 20ton
Release date: 2024-06-06

71675-87-1, 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acidRelated Search:

Methyl 4-amino-5-ethylsulfonyl-2-methoxybenzoate 4-Methoxybenzoic acid 4-Dimethylaminobenzoic acid 4-Aminobenzoic acid 4,4'-Diaminodiphenylsulfone 2-Methoxybenzoic acid Glycine ALTRENOGEST Anthranilic acid 2-Methoxy-5-(methylsulfonyl)benzoic acid 3-(METHYLSULFONYL)BENZOIC ACID 1-METHOXY-2-METHYL-4-(METHYLTHIO)BENZENE, 97 4-AMINO-3-MERCAPTOBENZOIC ACID 2-Methoxy-5-(ethylsulfonyl)benzoic acid 2-Methoxy-4-amino-5-ethylthiobenzoic acid 4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide DesMethyl AMisulpride 4-AMINO-2-METHOXY-5-MERCAPTOBENZOIC ACID

2-methoxyl-4-amine-5-ethylsulfonylbenzoic acid

AMisulpride Acid

4-AMINO-5-ETHANESULFONYL-2-METHOXY-BENZOIC ACID

4-AMINO-5-(ETHYLSULFONYL)-2-METHOXYBENZOIC ACID

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2-METHOXY-4-AMINO-5-ETHYLSULFONYLBENZOIC ACID

2-methoxy-4-amino-5-ethysulfonyl benzoic acid

2-METHOXY-4-AMINO-5-ETHYLSULFAMOYL BENZOIC ACID

BENZOICACID,4-AMINO-5-(ETHYLSULFONYL)-2-METHOXY

2-Methoxyl-4-amino-5-ethylsulfonylbenzoic acid

Amisulpride Impurity 5（Amisulpride EP Impurity E)

Amidic acid

4-Amino-5-(ethylsulphonyl)-2- methoxybenzoic Acid

Amisulpride EP Impurity E

4-Amino-5-ethylsulfo...

AMisulpride iMpurity (2-Methoxy-4-aMino-5-ethylsulfonylbenzoic Acid)

2-Methoxy-4-aMino-5-ethylsulphonyl benzoic acid

Ami acid

4-Amino-5-(ethylsulfonyl)

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid 2-METHOXY-4-AMINO-5-ETHYLSULFONYLBENZOIC ACID

4-AMINO-5-ETHYLSULFONYL-2-METHOXYBENZOIC ACID(AMISULPIRIDE INTERMEDIATES)

4 - AMINO - 2 - METHOXY - 5 – ETHYL SULFONYL BENZOIC ACID (71675-87-1)

4-Amino-5-(ethylsulphonyl)-2-methox

4-Amino-5-(ethylsulfonyl)-2-methoxybenzoicaci

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid ISO 9001：2015 REACH

4-Amino-2-Methoxy-5-Ethyl?Sulfonyl?Benzoic?Acid

Amisulpride EP Impurity EQ: What is Amisulpride EP Impurity E Q: What is the CAS Number of Amisulpride EP Impurity E Q: What is the storage condition of Amisulpride EP Impurity E

4-Amino-5-ethylsulfonyl-2-methoxybenzoicacid (ASP-V)

4-Amino-5-ethylsulfonyl-2-methoxybenz

e . 4-a mi no-5-(e th ylsulf onyl)-2-me th oxyb e nzoi c a c i d ,

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid (AMI ACID)

4-Amino-5-(Ethylsulfonyl)-2-Methoxybenzoic Acid 4--2--5-

71675-87-1

C10H13NO5S

API intermediates

Aromatics Compounds

Amines

Aromatics

Sulfur & Selenium Compounds

Organic acids