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4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid

Product Name
4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid
CAS No.
71675-87-1
Chemical Name
4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid
Synonyms
4-AMINO-5-(ETHYLSULFONYL)-2-METHOXYBENZOIC ACID;2-METHOXY-4-AMINO-5-ETHYLSULFONYLBENZOIC ACID;Ami acid;Amidic acid;AMisulpride Acid;4-Amino-5-ethylsulfo...;Amisulpride EP Impurity E;4-Amino-5-(ethylsulfonyl);4-Amino-5-(ethylsulphonyl)-2-methox;4-Amino-5-ethylsulfonyl-2-methoxybenz
CBNumber
CB4763363
Molecular Formula
C10H13NO5S
Formula Weight
259.28
MOL File
71675-87-1.mol
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4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Property

Melting point:
82-85°C
Boiling point:
529.6±50.0 °C(Predicted)
Density 
1.390±0.06 g/cm3(Predicted)
vapor pressure 
0Pa at 25℃
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
4.09±0.10(Predicted)
color 
White to buff coloured powder
Water Solubility 
8.555g/L at 25℃
InChI
InChI=1S/C10H13NO5S/c1-3-17(14,15)9-4-6(10(12)13)8(16-2)5-7(9)11/h4-5H,3,11H2,1-2H3,(H,12,13)
InChIKey
OJVNCXHGGYYOPH-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC(S(CC)(=O)=O)=C(N)C=C1OC
LogP
0.46
CAS DataBase Reference
71675-87-1(CAS DataBase Reference)
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Safety

HazardClass 
IRRITANT
HS Code 
29225090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2615
Product name
4-Amino-5-(ethylsulfonyl)-2-methoxybenzoic Acid
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$31
Updated
2025/07/31
TCI Chemical
Product number
A2615
Product name
4-Amino-5-(ethylsulfonyl)-2-methoxybenzoic Acid
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$153
Updated
2025/07/31
TRC
Product number
M260880
Product name
2-Methoxy-4-amino-5-ethylsulfonylbenzoicAcid
Packaging
250mg
Price
$155
Updated
2021/12/16
Usbiological
Product number
281778
Product name
2-Methoxy-4-amino-5-ethylsulfonyl benzoic acid
Packaging
100g
Price
$460
Updated
2021/12/16
TRC
Product number
M260880
Product name
2-Methoxy-4-amino-5-ethylsulfonylbenzoicAcid
Packaging
100mg
Price
$120
Updated
2021/12/16
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4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Chemical Properties,Usage,Production

Chemical Properties

Slightly Pink Solid

Uses

An impurity found in amisulpride (A633250). Amisulpride EP Impurity E

Flammability and Explosibility

Not classified

Synthesis

1119455-01-4

71675-87-1

The general procedure for the synthesis of 4-amino-5-(ethylsulfonyl)-2-methoxybenzoic acid using amisulpride impurity 4 as a starting material was as follows: 30% hydrogen peroxide was slowly added to isopropanol (4.84 L) at ambient temperature containing a catalytic amount of sodium tungstate (0.0082 kg) in 4-amino-2-methoxy-5-ethylthiomethyl benzoate (X) (1.21 kg) solution. The reaction mixture was stirred at 40-45 °C for 3-4 hours and subsequently cooled to 5-10 °C. To the reaction mixture, 5% sodium thiosulfate solution (0.06 kg dissolved in 18.15 L of water) was added and stirring was continued for 60 min to produce methyl 2-methoxy-4-amino-5-ethylsulfonylbenzoate (XI) in situ. Subsequently, sodium hydroxide (1.00 kg dissolved in 10 L of water) was added to the reaction mixture, warmed to 60-65 °C and stirred for 2-3 hours. Upon completion of the reaction, the reaction material was cooled and the pH was adjusted to 4.0-4.5 with dilute hydrochloric acid (1:10). the product was isolated by diafiltration in 82% yield and 99% purity.

References

[1] Patent: WO2011/158084, 2011, A1. Location in patent: Page/Page column 12
[2] Patent: WO2011/158084, 2011, A1

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Suppliers

Americas 1 Canada 5 China 297 Europe 3 Germany 2 India 64 Japan 1 Ukraine 1 United Kingdom 9 United States 36 Global 419
TCI Europe
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320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
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Europe
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ecochem international chemical broker
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export@ecochem.dk
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View Lastest Price from 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid 71675-87-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-21
Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid 71675-87-1
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-12-10
Hebei Ganmiao New material Technology Co., LTD
Product
4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid 71675-87-1
Price
US $10.00-7.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20ton
Release date
2024-06-06

71675-87-1, 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acidRelated Search:

Methyl 4-amino-5-ethylsulfonyl-2-methoxybenzoate 4-Methoxybenzoic acid 4-Dimethylaminobenzoic acid 4-Aminobenzoic acid 4,4'-Diaminodiphenylsulfone 2-Methoxybenzoic acid Glycine ALTRENOGEST Anthranilic acid 2-Methoxy-5-(methylsulfonyl)benzoic acid 3-(METHYLSULFONYL)BENZOIC ACID 1-METHOXY-2-METHYL-4-(METHYLTHIO)BENZENE, 97 4-AMINO-3-MERCAPTOBENZOIC ACID 2-Methoxy-5-(ethylsulfonyl)benzoic acid 2-Methoxy-4-amino-5-ethylthiobenzoic acid 4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide DesMethyl AMisulpride 4-AMINO-2-METHOXY-5-MERCAPTOBENZOIC ACID

  • 2-methoxyl-4-amine-5-ethylsulfonylbenzoic acid
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  • 4-AMINO-5-ETHANESULFONYL-2-METHOXY-BENZOIC ACID
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  • 2-methoxy-4-amino-5-ethysulfonyl benzoic acid
  • 2-METHOXY-4-AMINO-5-ETHYLSULFAMOYL BENZOIC ACID
  • BENZOICACID,4-AMINO-5-(ETHYLSULFONYL)-2-METHOXY
  • 2-Methoxyl-4-amino-5-ethylsulfonylbenzoic acid
  • Amisulpride Impurity 5（Amisulpride EP Impurity E)
  • Amidic acid
  • 4-Amino-5-(ethylsulphonyl)-2- methoxybenzoic Acid
  • Amisulpride EP Impurity E
  • 4-Amino-5-ethylsulfo...
  • AMisulpride iMpurity (2-Methoxy-4-aMino-5-ethylsulfonylbenzoic Acid)
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  • Ami acid
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  • 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid 2-METHOXY-4-AMINO-5-ETHYLSULFONYLBENZOIC ACID
  • 4-AMINO-5-ETHYLSULFONYL-2-METHOXYBENZOIC ACID(AMISULPIRIDE INTERMEDIATES)
  • 4 - AMINO - 2 - METHOXY - 5 – ETHYL SULFONYL BENZOIC ACID (71675-87-1)
  • 4-Amino-5-(ethylsulphonyl)-2-methox
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  • 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid ISO 9001：2015 REACH
  • 4-Amino-2-Methoxy-5-Ethyl?Sulfonyl?Benzoic?Acid
  • Amisulpride EP Impurity EQ: What is Amisulpride EP Impurity E Q: What is the CAS Number of Amisulpride EP Impurity E Q: What is the storage condition of Amisulpride EP Impurity E
  • 4-Amino-5-ethylsulfonyl-2-methoxybenzoicacid (ASP-V)
  • 4-Amino-5-ethylsulfonyl-2-methoxybenz
  • e . 4-a mi no-5-(e th ylsulf onyl)-2-me th oxyb e nzoi c a c i d ,
  • 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid (AMI ACID)
  • 4-Amino-5-(Ethylsulfonyl)-2-Methoxybenzoic Acid 4--2--5-
  • 71675-87-1
  • C10H13NO5S
  • API intermediates
  • Aromatics Compounds
  • Amines
  • Aromatics
  • Sulfur & Selenium Compounds
  • Organic acids