ChemicalBook > CAS DataBase List > Disuccinimidyl glutarate

Disuccinimidyl glutarate

Product Name
Disuccinimidyl glutarate
CAS No.
79642-50-5
Chemical Name
Disuccinimidyl glutarate
Synonyms
DSG;DG1;CDHF4;EPKHE;PPKS1;SPPK1;EPKHIA;DSG Crosslinker;DISUCCINIMIDYL GLUTARATE;DI(N-SUCCINIMIDYL) GLUTARATE
CBNumber
CB0373852
Molecular Formula
C13H14N2O8
Formula Weight
326.26
MOL File
79642-50-5.mol
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Disuccinimidyl glutarate Property

Melting point:
168-172 °C
Boiling point:
485.1±55.0 °C(Predicted)
Density 
1.53±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in dimethylsulfoxide and dimethylformamide.
form 
Solid
color 
White to Off-White
Appearance
White solid
Water Solubility 
Partially soluble in water.
Sensitive 
Moisture Sensitive
BRN 
8575145
Stability:
Hygroscopic, Moisture Sensitive, Unstable in Aqueous Solution
InChI
InChI=1S/C13H14N2O8/c16-8-4-5-9(17)14(8)22-12(20)2-1-3-13(21)23-15-10(18)6-7-11(15)19/h1-7H2
InChIKey
LNQHREYHFRFJAU-UHFFFAOYSA-N
SMILES
C(ON1C(=O)CCC1=O)(=O)CCCC(ON1C(=O)CCC1=O)=O
CAS DataBase Reference
79642-50-5
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
10-21
HS Code 
29280000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
80424
Product name
Di(N-succinimidyl) glutarate
Purity
≥97.0% (CHN)
Packaging
5mg
Price
$45.4
Updated
2025/07/31
Sigma-Aldrich
Product number
80424
Product name
Di(N-succinimidyl) glutarate
Purity
≥97.0% (CHN)
Packaging
50mg
Price
$338
Updated
2025/07/31
Sigma-Aldrich
Product number
SAB2501785
Product name
Anti-DSG1 antibody produced in goat
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
100μG
Price
$545
Updated
2023/01/07
TCI Chemical
Product number
D5445
Product name
Disuccinimidyl Glutarate
Packaging
250MG
Price
$100
Updated
2025/07/31
Cayman Chemical
Product number
20646
Product name
Disuccinimidyl Glutarate
Purity
≥95%
Packaging
5mg
Price
$32
Updated
2024/03/01
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Disuccinimidyl glutarate Chemical Properties,Usage,Production

Description

Disuccinimidyl glutarate (DSG) is a homobifunctional crosslinking agent that contains amine-reactive N-hydroxysuccinimide (NHS) ester groups at each end. DSG is membrane-permeable and non-cleavable. DSG can be combined with formaldehyde fixation to improve the detection of specific protein-DNA complexes.

Chemical Properties

DSG crosslinker (Disuccinimidyl glutarate; Di(N-succinimidyl) glutarate) is a homobifunctional crosslinking reagent that is membrane permeable. DSG protein crosslinker is often used in ChIP assays to determine DNA-protein binding interactions; using DSG and formaldehyde in a two-step crosslinking strategy greatly improves the ChIP assay. Disuccinimidyl crosslinkers include disuccinimidyl glutarate (DSG), disuccinimidyl suberate (DSS), and bis-N-succinimidyl-(pentaethylene glycol) ester (BS(PEG)5)[1]. DSG crosslinking takes place through amine-reactive NHS esters at both ends of a 5-atom (7.7 angstrom) spacer arm. DSS (crosslinker arm length = 11.4Å), DSG (crosslinker arm length = 7.5Å), and disuccinimidyl tartrate (DST, crosslinker arm length = 5.8Å) are homobifunctional crosslinking reagents that react specifically with primary amines[2]. DSG crosslinker must be dissolved in an organic solvent, such as DMSO or DMF, and then added to an aqueous crosslinking reaction. The directly water-soluble version of Di(N-succinimidyl) glutarate (DSG) is BS2G.

Characteristics

Features of disuccinimidyl glutarate:
Reactive groups: NHS ester (both ends)
Reactive towards: amino groups (primary amines)
Non-cleavable
Water-insoluble (dissolve first in DMF or DMSO)
Membrane-permeable, allowing for intracellular crosslinking
Can increase crosslinking efficiency compared to DSS in some applications

Uses

Disuccinimidyl glutarate is used as a membrane-soluble, amine-reactive N-hydroxysuccinamide ester-based homobifunctional crosslinking reagent. It is a homobifunctionla cross-linking reagent, for ex. isolation of the insulin receptor.

General Description

DSG crosslinker (Disuccinimidyl glutarate; Di(N-succinimidyl) glutarate) is a homobifunctional crosslinking reagent that is membrane permeable. DSG protein crosslinker is often used in ChIP assays to determine DNA-protein binding interactions; using DSG and formaldehyde in a two-step cross-linking strategy greatly improves the ChIP assay.
DSG crosslinking takes place through amine-reactive NHS esters at both ends of a 5-atom (7.7 angstrom) spacer arm. DSG crosslinker must be dissolved in an organic solvent, such as DMSO or DMF, then added to an aqueous crosslinking reaction. The directly water soluble version of Di(N-succinimidyl) glutarate (DSG) is BS2G.

reaction suitability

reagent type: cross-linking reagent

References

[1] JeeYoung Kim, Min Park, Gun Yong Sung. “Efficient Portable Urea Biosensor Based on Urease Immobilized Membrane for Monitoring of Physiological Fluids.” Biomedicines (2020).
[2] Petr Novak. “A top-down approach to protein structure studies using chemical cross-linking and Fourier transform mass spectrometry.” European Journal of Mass Spectrometry 9 6 (2003): 623–31.

Disuccinimidyl glutarate Preparation Products And Raw materials

Raw materials

Preparation Products

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Disuccinimidyl glutarate Suppliers

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View Lastest Price from Disuccinimidyl glutarate manufacturers

Hangzhou Huarong Pharm Co., Ltd.
Product
DSG Crosslinker 79642-50-5
Price
US $0.00-0.00/g
Min. Order
100mg
Purity
99%
Supply Ability
100KG
Release date
2021-09-15
Honest Joy Holdings Limited
Product
bis(2,5-dioxopyrrolidin-1-yl)pentanedioate 79642-50-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99.2%
Supply Ability
100 tons
Release date
2022-01-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
DISUCCINIMIDYL GLUTARATE 79642-50-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

79642-50-5, Disuccinimidyl glutarateRelated Search:

Bicyclo<2.2.2>octa-2.5-dien-2-carbonsaeureaethylester NORBORNANE-2-CARBOXALDEHYDE Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic anhydride Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester Diethyl carbonate Suberate Bis(sulfosuccinimidyl) Sodium Salt DISUCCINIMIDYL SUBERATE Diethyl bis(hydroxymethyl)malonate Tetramethyl glutaric aciduria DISUCCINIMIDYL GLUTARATE; DSG Disuccinimidyl glutarate Nonanedioic acid 1,9-bis(2,5-dioxo-1-pyrrolidinyl) ester alpha, oMega-DisucciniMidyl triethylene glycol

  • DI(N-SUCCINIMIDYL) GLUTARATE
  • DSG
  • DISUCCINIMIDYL GLUTARATE
  • Di(N-hydroxysucciniMidyl) glutarate
  • 2,5-Pyrrolidinedione, 1,1'-[(1,5-dioxo-1,5-pentanediyl)bis(oxy)]bis-
  • Anti-DSG1 antibody produced in goat
  • CDHF4
  • DG1
  • DSG Crosslinker
  • bis(2,5-dioxopyrrolidin-1-yl) pentanedioate
  • DSG [Di(N-succinimidyl) glutarate] *CAS 79642-50-5*
  • Pentanedioic acid,1,5-bis(2,5-dioxo-1-pyrrolidinyl) ester
  • N,N'-Disuccinimidyl Glutarate
  • DSG [Di(N-succinimidyl) glutarate
  • Bis(2,5-dioxopyrrolidin-1-yl) glutarate
  • Disuccinimidyl Glutarate (>97%)
  • ADC Linkers,linker,inhibit,Inhibitor,cleavable,DSG Crosslinker,Antibody-drug conjugates linkers,ADC
  • DSG Crosslinker, 10 mM in DMSO
  • 1,1'-[(1,5-Dioxo-1,5-pentanediyl)-bis-(oxy)]-bis-(2,5-pyrrolidinedione)
  • EPKHE
  • EPKHIA
  • PPKS1
  • SPPK1
  • 79642-50-5
  • C13H14N2O8
  • Homobifunctional Crosslinker