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Disuccinimidyl glutarate

Product Name
Disuccinimidyl glutarate
CAS No.
79642-50-5
Chemical Name
Disuccinimidyl glutarate
Synonyms
DSG;DG1;CDHF4;DSG Crosslinker;DISUCCINIMIDYL GLUTARATE;DI(N-SUCCINIMIDYL) GLUTARATE;N,N'-Disuccinimidyl Glutarate;Disuccinimidyl Glutarate (>97%);DSG [Di(N-succinimidyl) glutarate;Di(N-hydroxysucciniMidyl) glutarate
CBNumber
CB0373852
Molecular Formula
C13H14N2O8
Formula Weight
326.26
MOL File
79642-50-5.mol
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Disuccinimidyl glutarate Property

Melting point:
168-172 °C
Boiling point:
485.1±55.0 °C(Predicted)
Density 
1.53±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in dimethylsulfoxide and dimethylformamide.
form 
Solid
color 
White to Off-White
Water Solubility 
Partially soluble in water.
Sensitive 
Moisture Sensitive
BRN 
8575145
Stability:
Hygroscopic, Moisture Sensitive, Unstable in Aqueous Solution
InChI
InChI=1S/C13H14N2O8/c16-8-4-5-9(17)14(8)22-12(20)2-1-3-13(21)23-15-10(18)6-7-11(15)19/h1-7H2
InChIKey
LNQHREYHFRFJAU-UHFFFAOYSA-N
SMILES
C(ON1C(=O)CCC1=O)(=O)CCCC(ON1C(=O)CCC1=O)=O
CAS DataBase Reference
79642-50-5
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
10-21
HS Code 
29280000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
80424
Product name
Di(N-succinimidyl) glutarate
Purity
≥97.0% (CHN)
Packaging
5mg
Price
$42.8
Updated
2024/03/01
Sigma-Aldrich
Product number
80424
Product name
Di(N-succinimidyl) glutarate
Purity
≥97.0% (CHN)
Packaging
50mg
Price
$318
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB2501785
Product name
Anti-DSG1 antibody produced in goat
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
100μG
Price
$545
Updated
2023/01/07
Alfa Aesar
Product number
H58208
Product name
Disuccinimidyl glutarate, 97%
Packaging
100mg
Price
$128
Updated
2024/03/01
Alfa Aesar
Product number
H58208
Product name
Disuccinimidyl glutarate, 97%
Packaging
500mg
Price
$470
Updated
2024/03/01
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Disuccinimidyl glutarate Chemical Properties,Usage,Production

Description

Disuccinimidyl glutarate (DSG) is a homobifunctional crosslinking agent that contains amine-reactive N-hydroxysuccinimide (NHS) ester groups at each end. DSG is membrane-permeable and non-cleavable. DSG can be combined with formaldehyde fixation to improve the detection of specific protein-DNA complexes.

Chemical Properties

DSG crosslinker (Disuccinimidyl glutarate; Di(N-succinimidyl) glutarate) is a homobifunctional crosslinking reagent that is membrane permeable. DSG protein crosslinker is often used in ChIP assays to determine DNA-protein binding interactions; using DSG and formaldehyde in a two-step crosslinking strategy greatly improves the ChIP assay. Disuccinimidyl crosslinkers include disuccinimidyl glutarate (DSG), disuccinimidyl suberate (DSS), and bis-N-succinimidyl-(pentaethylene glycol) ester (BS(PEG)5)[1]. DSG crosslinking takes place through amine-reactive NHS esters at both ends of a 5-atom (7.7 angstrom) spacer arm. DSS (crosslinker arm length = 11.4Å), DSG (crosslinker arm length = 7.5Å), and disuccinimidyl tartrate (DST, crosslinker arm length = 5.8Å) are homobifunctional crosslinking reagents that react specifically with primary amines[2]. DSG crosslinker must be dissolved in an organic solvent, such as DMSO or DMF, and then added to an aqueous crosslinking reaction. The directly water-soluble version of Di(N-succinimidyl) glutarate (DSG) is BS2G.

Characteristics

Features of disuccinimidyl glutarate:
Reactive groups: NHS ester (both ends)
Reactive towards: amino groups (primary amines)
Non-cleavable
Water-insoluble (dissolve first in DMF or DMSO)
Membrane-permeable, allowing for intracellular crosslinking
Can increase crosslinking efficiency compared to DSS in some applications

Uses

Disuccinimidyl glutarate is used as a membrane-soluble, amine-reactive N-hydroxysuccinamide ester-based homobifunctional crosslinking reagent. It is a homobifunctionla cross-linking reagent, for ex. isolation of the insulin receptor.

General Description

DSG crosslinker (Disuccinimidyl glutarate; Di(N-succinimidyl) glutarate) is a homobifunctional crosslinking reagent that is membrane permeable. DSG protein crosslinker is often used in ChIP assays to determine DNA-protein binding interactions; using DSG and formaldehyde in a two-step cross-linking strategy greatly improves the ChIP assay.
DSG crosslinking takes place through amine-reactive NHS esters at both ends of a 5-atom (7.7 angstrom) spacer arm. DSG crosslinker must be dissolved in an organic solvent, such as DMSO or DMF, then added to an aqueous crosslinking reaction. The directly water soluble version of Di(N-succinimidyl) glutarate (DSG) is BS2G.

References

[1] JeeYoung Kim, Min Park, Gun Yong Sung. “Efficient Portable Urea Biosensor Based on Urease Immobilized Membrane for Monitoring of Physiological Fluids.” Biomedicines (2020).
[2] Petr Novak. “A top-down approach to protein structure studies using chemical cross-linking and Fourier transform mass spectrometry.” European Journal of Mass Spectrometry 9 6 (2003): 623–31.

Disuccinimidyl glutarate Preparation Products And Raw materials

Raw materials

Preparation Products

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Disuccinimidyl glutarate Suppliers

Suzhouhongxiong
Tel
18051745768 18051745768
Email
Suzhouhongxiong@163.com
Country
China
ProdList
60
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58
ShangHai ShuaiDian MEDICAL TECHNOLOGY CO.,LTD.
Tel
15821556986
Email
shshuaidian@126.com
Country
China
ProdList
125
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58
Nanjing Xinsi Chemical Co., Ltd.
Tel
18805263762
Email
nanjingxinsi@163.com
Country
China
ProdList
434
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58
Guangzhou Weihua Biotechnology Co., Ltd
Tel
020-020-37239396 18922492046
Email
weihuasw@foxmail.com
Country
China
ProdList
2124
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58
Shanghai Valuable Catalysts Pharmaceutical Co. Ltd
Tel
15618570478 13331882176
Fax
QQ 2253973700 weixin: 389106536
Email
2253973700@qq.com
Country
China
ProdList
264
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Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
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61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
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60
Nanjing Habo Medical Technology Co., Ltd.
Tel
025-85760892 13376090521
Fax
025-85766769
Email
sales@habotech.com
Country
China
ProdList
970
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60
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
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57
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View Lastest Price from Disuccinimidyl glutarate manufacturers

Hangzhou Huarong Pharm Co., Ltd.
Product
DSG Crosslinker 79642-50-5
Price
US $0.00-0.00/g
Min. Order
100mg
Purity
99%
Supply Ability
100KG
Release date
2021-09-15
Honest Joy Holdings Limited
Product
bis(2,5-dioxopyrrolidin-1-yl)pentanedioate 79642-50-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99.2%
Supply Ability
100 tons
Release date
2022-01-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
DISUCCINIMIDYL GLUTARATE 79642-50-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

79642-50-5, Disuccinimidyl glutarateRelated Search:


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  • DSG
  • DISUCCINIMIDYL GLUTARATE
  • Di(N-hydroxysucciniMidyl) glutarate
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  • Anti-DSG1 antibody produced in goat
  • CDHF4
  • DG1
  • DSG Crosslinker
  • bis(2,5-dioxopyrrolidin-1-yl) pentanedioate
  • DSG [Di(N-succinimidyl) glutarate] *CAS 79642-50-5*
  • Pentanedioic acid,1,5-bis(2,5-dioxo-1-pyrrolidinyl) ester
  • N,N'-Disuccinimidyl Glutarate
  • DSG [Di(N-succinimidyl) glutarate
  • Bis(2,5-dioxopyrrolidin-1-yl) glutarate
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  • ADC Linkers,linker,inhibit,Inhibitor,cleavable,DSG Crosslinker,Antibody-drug conjugates linkers,ADC
  • 79642-50-5
  • C13H14N2O8
  • Homobifunctional Crosslinker