DL-Mevalonolactone
- Product Name
- DL-Mevalonolactone
- CAS No.
- 674-26-0
- Chemical Name
- DL-Mevalonolactone
- Synonyms
- NSC 90804;Beta-Hydro;Hyperpure-MVA;MEVALONOLACTONE;DL-MEVALOLACTONE;MEVALONIC LACTONE;DL-MEVALONOLACTONE;(+/-)-MEVALONOLACTONE;Adeka Mevalonolactone;DL-Mevalonolactone >
- CBNumber
- CB0377087
- Molecular Formula
- C6H10O3
- Formula Weight
- 130.14
- MOL File
- 674-26-0.mol
DL-Mevalonolactone Property
- Melting point:
- 28 °C(lit.)
- Boiling point:
- 145-150 °C5 mm Hg(lit.)
- alpha
- -1.0~+1.0°(20℃/D)(c=5, C2H5OH)
- Density
- 1.1066 (rough estimate)
- refractive index
- n20/D 1.473(lit.)
- Flash point:
- >230 °F
- storage temp.
- -20°C
- solubility
- Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate, Methanol (Slightly)
- form
- Oil
- pka
- 13.57±0.20(Predicted)
- color
- Pale Yellow to Dark Brown
- Merck
- 14,6163
- BRN
- 80960
- Stability:
- Hygroscopic
- InChIKey
- JYVXNLLUYHCIIH-UHFFFAOYSA-N
- CAS DataBase Reference
- 674-26-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Dl-mevalonic acid lactone(674-26-0)
Safety
- WGK Germany
- 3
- F
- 3-10
- HS Code
- 29322090
N-Bromosuccinimide Price
- Product number
- M4667
- Product name
- (±)-Mevalonolactone
- Purity
- ~97% (titration)
- Packaging
- 1g
- Price
- $221
- Updated
- 2024/03/01
- Product number
- M4667
- Product name
- (±)-Mevalonolactone
- Purity
- ~97% (titration)
- Packaging
- 5g
- Price
- $687
- Updated
- 2024/03/01
- Product number
- D0587
- Product name
- DL-Mevalonolactone
- Purity
- >98.0%(GC)
- Packaging
- 100mg
- Price
- $67
- Updated
- 2024/03/01
- Product number
- 20348
- Product name
- DL-Mevalonolactone
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 20348
- Product name
- DL-Mevalonolactone
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $92
- Updated
- 2024/03/01
DL-Mevalonolactone Chemical Properties,Usage,Production
Description
DL-Mevalonolactone is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. It induces depolarization and swelling, decreases NADPH content and aconitase (ACO) activity, and increases malondialdehyde (MDA) production in calcium-loaded rat brain mitochondria. DL-Mevalonolactone reverses decreases in glucose uptake induced by simvastatin (Item Nos. 10010344 | 10010345) in L6 myotubes. Tissue levels and urinary excretion of DL-mevalonolactone are increased in patients with mevalonic aciduria, a disorder characterized by a deficiency in mevalonic kinase activity.
Chemical Properties
Pale Yellow Oil
Uses
A metabolite from endophytes of the medicinal plant Erythrina crista-galli.
Uses
HMG CoA substrate
Uses
(±)-Mevalonolactone is used to:
- study the effect of statin on the prenylation of Ras and Rho GTPases
- analyse the isoprenoid biosynthesis pathways in Listeria monocytogenes
- study the the effects of statins on proliferation and migration of HUVECs (HGF-induced human umbilical vein endothelial cells)
Definition
ChEBI: 4-hydroxy-4-methyl-2-oxanone is a delta-lactone.
Synthesis Reference(s)
Journal of the American Chemical Society, 104, p. 5486, 1982 DOI: 10.1021/ja00384a040
Synthesis, p. 719, 1974 DOI: 10.1055/s-1974-23416
General Description
Alkaline hydrolysis of mevalonolactone gives mevalonate. Mevalonate is a precursor of farnesyl and geranylgeranyl pyrophosphates. These pyrophosphates are required for protein prenylation.
Purification Methods
Purify the lactone via the dibenzyl-ethylenediammonium salt (m 124-125o) [Hofmann et al. J Am Chem Soc 79 2316 1957], or by chromatography on paper or on a Dowex-1 (formate) column. [Bloch et al. J Biol Chem 234 2595 1959.] Store it as the N,N'-dibenzylethylenediamine (DBED) salt, or as the lactone in a sealed container at 0o. [Beilstein 18/1 V 19.]
DL-Mevalonolactone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DL-Mevalonolactone manufacturers
- Product
- DL-Mevalonolactone 674-26-0
- Price
- US $79.00-38.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-11-19
- Product
- Mevalonolactone 674-26-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-05
- Product
- DL-Mevalonolactone 674-26-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-11-27