DL-Mevalonolactone

ChemicalBook > CAS DataBase List > DL-Mevalonolactone

DL-Mevalonolactone

Product Name: DL-Mevalonolactone
CAS No.: 674-26-0
Chemical Name: DL-Mevalonolactone
Synonyms: NSC 90804;Beta-Hydro;Hyperpure-MVA;MEVALONOLACTONE;DL-MEVALOLACTONE;MEVALONIC LACTONE;DL-MEVALONOLACTONE;(+/-)-MEVALONOLACTONE;DL-Mevalonolactone >DL-MEVALONIC ACID LACTONE
CBNumber: CB0377087
Molecular Formula: C6H10O3
Formula Weight: 130.14
MOL File: 674-26-0.mol

Less

DL-Mevalonolactone Property

Melting point:: 28 °C(lit.)
Boiling point:: 145-150 °C5 mm Hg(lit.)
alpha: -1.0～+1.0°(20℃/D)(c=5, C2H5OH)
Density: 1.1066 (rough estimate)
refractive index: n20/D 1.473(lit.)
Flash point:: >230 °F
storage temp.: -20°C
solubility: Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate, Methanol (Slightly)
form: Oil
pka: 13.57±0.20(Predicted)
color: Pale Yellow to Dark Brown
Merck: 14,6163
BRN: 80960
Stability:: Hygroscopic
InChIKey: JYVXNLLUYHCIIH-UHFFFAOYSA-N
CAS DataBase Reference: 674-26-0(CAS DataBase Reference)
NIST Chemistry Reference: Dl-mevalonic acid lactone(674-26-0)

Less

Safety

WGK Germany: 3
F: 3-10
HS Code: 29322090

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M4667
Product name: (±)-Mevalonolactone
Purity: ~97% (titration)
Packaging: 1g
Price: $221
Updated: 2024/03/01

Sigma-Aldrich

Product number: M4667
Product name: (±)-Mevalonolactone
Purity: ~97% (titration)
Packaging: 5g
Price: $687
Updated: 2024/03/01

TCI Chemical

Product number: D0587
Product name: DL-Mevalonolactone
Purity: >98.0%(GC)
Packaging: 100mg
Price: $67
Updated: 2024/03/01

Cayman Chemical

Product number: 20348
Product name: DL-Mevalonolactone
Purity: ≥95%
Packaging: 250mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 20348
Product name: DL-Mevalonolactone
Purity: ≥95%
Packaging: 500mg
Price: $92
Updated: 2024/03/01

Less

DL-Mevalonolactone Chemical Properties,Usage,Production

Description

DL-Mevalonolactone is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. It induces depolarization and swelling, decreases NADPH content and aconitase (ACO) activity, and increases malondialdehyde (MDA) production in calcium-loaded rat brain mitochondria. DL-Mevalonolactone reverses decreases in glucose uptake induced by simvastatin (Item Nos. 10010344 | 10010345) in L6 myotubes. Tissue levels and urinary excretion of DL-mevalonolactone are increased in patients with mevalonic aciduria, a disorder characterized by a deficiency in mevalonic kinase activity.

Chemical Properties

Pale Yellow Oil

Uses

A metabolite from endophytes of the medicinal plant Erythrina crista-galli.

Uses

HMG CoA substrate

Uses

(±)-Mevalonolactone is used to:

study the effect of statin on the prenylation of Ras and Rho GTPases
analyse the isoprenoid biosynthesis pathways in Listeria monocytogenes
study the the effects of statins on proliferation and migration of HUVECs (HGF-induced human umbilical vein endothelial cells)

Definition

ChEBI: 4-hydroxy-4-methyl-2-oxanone is a delta-lactone.

Synthesis Reference(s)

Journal of the American Chemical Society, 104, p. 5486, 1982 DOI: 10.1021/ja00384a040
Synthesis, p. 719, 1974 DOI: 10.1055/s-1974-23416

General Description

Alkaline hydrolysis of mevalonolactone gives mevalonate. Mevalonate is a precursor of farnesyl and geranylgeranyl pyrophosphates. These pyrophosphates are required for protein prenylation.

Purification Methods

Purify the lactone via the dibenzyl-ethylenediammonium salt (m 124-125o) [Hofmann et al. J Am Chem Soc 79 2316 1957], or by chromatography on paper or on a Dowex-1 (formate) column. [Bloch et al. J Biol Chem 234 2595 1959.] Store it as the N,N'-dibenzylethylenediamine (DBED) salt, or as the lactone in a sealed container at 0o. [Beilstein 18/1 V 19.]

DL-Mevalonolactone Preparation Products And Raw materials

Raw materials

Preparation Products

Less

DL-Mevalonolactone Suppliers

Americas 1 Belgium 2 Canada 2 CHINA 128 Europe 1 France 3 Germany 3 India 4 Japan 4 Switzerland 3 Ukraine 1 United Kingdom 12 United States 37 Global 201

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7955
Advantage: 58

Tianjin Zhongcheng Mingyuan Technology Co., Ltd.

Tel: 13302022156
Fax: -
Email: 3506745780@qq.com
Country: China
ProdList: 171
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40240
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 18089
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel
Country: China
ProdList: 42982
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Wuhan Luohua Medical Technology Co.,Ltd.

Tel: 13477084141; 13477084141
Fax: +86(27)65566697
Email: sales@luohuapharm.com
Country: China
ProdList: 469
Advantage: 60

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12990
Advantage: 57

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11714
Advantage: 57

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9664
Advantage: 60

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17779
Advantage: 75

Wuxi Zhangkun Biochemical Technology Co., Ltd.

Tel: +86 0510-85629785
Fax: +86 0510-85625359
Country: China
ProdList: 2331
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7854
Advantage: 58

Shanghai Meishui Chemical Technology Co., Ltd

Tel: 021-60549325 18616193163
Fax: 021-33250306
Country: China
ProdList: 4528
Advantage: 56

3B Scientific (Wuhan) Corporation Limited

Tel: 0086-27-88063677 18186135292
Fax: 027-88063656
Email: sales@3bsc.com
Country: China
ProdList: 293
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41438
Advantage: 60

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15185
Advantage: 58

Shanghai Balmxy Pharmaceutical Co., Ltd

Tel: 021-24206007 13764915196
Fax: 86-021-23027023
Email: sales@balmxy.com
Country: China
ProdList: 6730
Advantage: 55

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15878
Advantage: 55

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4992
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai Synchem Pharma Co., ltd

Tel: 021-61984905-1 18016477331
Email: synchempharma@aliyun.com
Country: China
ProdList: 6456
Advantage: 55

Tianjin BaihengBoye Technology Co., Ltd.

Tel: 15822926937
Fax: -
Email: changlu@baihengtech.com
Country: China
ProdList: 44
Advantage: 55

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10457
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27322
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Hubei Hongxin Ruiyu Fine Chemical Co., Ltd.

Tel: 027-65526929 15102793023
Fax: 027-65526669
Email: hbhxry@163.com
Country: China
ProdList: 2060
Advantage: 55

Guangzhou Jhd Chemical Reagent Co., Ltd.

Tel: 020-84383047
Fax: 020-84380294
Email: sales@jhd.com.cn
Country: China
ProdList: 9190
Advantage: 65

JinJin Le Chemical Co., Ltd

Tel: 10106090
Email: jjlchem2@163.com
Country: China
ProdList: 9986
Advantage: 58

Hubei XinMingTai Chemical Co., Ltd.

Tel: 177-7179-1433 17771741533
Fax: 027-62437337
Email: 1228159977@qq.com
Country: China
ProdList: 1299
Advantage: 58

Aikon International Limited

Tel: 025-66028182 18112977050
Fax: (3)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 15820
Advantage: 58

SHANGHAI FDC-CHEMICAL CO.,LTD

Tel: 021-61469567 18521078705
Fax: 021-61161605
Email: sales@fdc-chemical.com
Country: China
ProdList: 19944
Advantage: 58

Shanghai He Huan Chemical Co., Ltd.

Tel: 021-60345187 13917602471
Fax: 021-60345187
Email: lzz841106@aliyun.com
Country: China
ProdList: 9908
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6038 18902104717
Email: sales@heowns.com
Country: China
ProdList: 20532
Advantage: 60

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: 021-58958618
Email: xiaoyangw@gmail.com
Country: China
ProdList: 2129
Advantage: 58

Shanghai Benso Pharmaceutical Technology Co., Ltd.

Tel: 15088289376
Email: 248775804@qq.com
Country: China
ProdList: 4975
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6870
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9730
Advantage: 58

Hubei Hongxin Ruiyu Fine Chemical Co., Ltd.

Tel: 027-027-65385071 17771822910
Fax: 027-65526669
Email: 2056564811@qq.com
Country: China
ProdList: 1752
Advantage: 58

Hebei Yanxi Chemical Co., Ltd.

Tel: +8617531190177
Email: peter@yan-xi.com
Country: China
ProdList: 6000
Advantage: 58

Henan Alfa Chemical Co., Ltd

Tel: +8618339805032
Email: alfa4@alfachem.cn
Country: China
ProdList: 12975
Advantage: 58

Labnetwork lnc.

Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Country: China
ProdList: 19994
Advantage: 58

Nextpeptide Inc

Tel: +86-0571-81612335 +8613336028439
Email: sales@nextpeptide.com
Country: China
ProdList: 19915
Advantage: 58

Hubei Ipure Biology Co., Ltd

Tel: +8613367258412
Fax: 18062427325
Email: ada@ipurechemical.com
Country: China
ProdList: 10326
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: CHINA
ProdList: 52867
Advantage: 58

Less

View Lastest Price from DL-Mevalonolactone manufacturers

Wuhan Quanjinci New Material Co.,Ltd.

Product: DL-Mevalonic acid lactone 674-26-0
Price: US $70.00-35.00/L
Min. Order: 1L
Purity: 0.99
Supply Ability: 1000000 tons
Release date: 2024-05-14

BINBO BIOLOGICAL CO.,LTD

Product: Mevalonolactone 674-26-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 1000 kg
Release date: 2024-04-05

airuikechemical co., ltd.

Product: DL-Mevalonolactone 674-26-0
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2024-04-11

674-26-0, DL-MevalonolactoneRelated Search:

Kresoxim-methyl Methyl acrylate METSULFURON METHYL D-Glucurone Methyl cellulose Butylated Hydroxytoluene Folic acid Citric acid DL-Malic acid 1-Hydroxyethylidene-1,1-diphosphonic acid D-(+)-Glucono-1,5-lactone Bensulfuron methyl Methanol CHLOROPHOSPHONAZO III Hyaluronic acid Triclosan Ethyl 2-(Chlorosulfonyl)acetate 3,5-Dihydroxybenzoic acid

DL-MEVALONOLACTONE

β-Hydroxy-β-methyl-δ-valerolactone, (±)-β-Hydroxy-β-methyl-δ-valerolactone, (±)-3-Hydroxy-3-methyl δ-valerolactone, (±)-Mevalolactone, (±)-Mevalonic acid lactone, (±)-Mevalonolactone

(4S)-4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one

(S)-3,5-Dihydroxy-3-methylpentanoic acid δ-lactone

(S)-4β-Hydroxy-4-methyltetrahydro-2H-pyran-2-one

(S)-Tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one

Beta-Hydro

(±)-Mevalonolactone,(±)-β-Hydroxy-β-methyl-δ-valerolactone, (±)-3-Hydroxy-3-methyl δ-valerolactone, DL-Mevalolactone, DL-Mevalonic acid lactone

Tetrahydro-4-hydroxy-4-Methyl-

beta-Hydroxy-beta-methyl-delta-valerolactone DL-Mevalonic Acid Lactone Tetrahydro-4-hydroxy-4-methyl-2-pyrone

tetrahydro-4-hydroxy-4-Methylpyran-2-one

DL-MEVALOLACTONE

DL-MEVALONIC ACID LACTONE

DL-BETA-HYDROXY-BETA-METHYL-DELTA-VALERO-LACTONE

DL-BETA-HYDROXY-BETA-METHYL-GAMMA-VALEROLACTONE

DL-BETA-HYDROXY-BETA-METHYL-G-VALEROLACTONE

DL-3-HYDROXY-3-METHYL DELTA-VALEROLACTONE

BETA-HYDROXY-BETA-METHYL-DELTA-VALEROLACTONE

MEVALONIC ACID LACTONE, DL-

MEVALONIC LACTONE

(+/-)-MEVALONOLACTONE

MEVALONOLACTONE

(+/-)-3-HYDROXY-3-METHYL-5-PENTANOLIDE

(4R)-4-Hydroxy-4-methyl-oxan-2-one

(+/-)-tetrahydro-4-hydroxy-4-methyl-2h-pyran-2-one

TETRAHYDRO-4-HYDROXY-4-METHYL-2-PYRONE

2H-Pyran-2-one, tetrahydro-4-hydroxy-4-methyl-, (.+/-.)-

4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one

D,L-b-Hydroxy-b-methyl-valerolactone

(±)-β-hydroxy-β-methyl-δ-valerolactone

MEVALONIC ACID LACTONE, DL-(RG)

D,L-MEVELONIC ACID LACTONE

DL-B-HYDROXY-B-METHYL-Y-VALEROLACTONE

D,L--Hydroxy--methyl--valerolactone

NSC 90804

(±)-β-Hydroxy-β-methyl-δ-valerolactone, (±)-3-Hydroxy-3-methyl δ-valerolactone, DL-Mevalolactone, DL-Mevalonic acid lactone

dl-mevalonic acid lactone, salt-free

DL-Mevalonolactone &gt

Mevalonolactone, racemic mixture

4-hydroxy-4-methyloxan-2-one

4-Hydroxy-4-methyltetrahydropyran-2-one

Hyperpure-MVA

674-26-0

Organic Building Blocks

Lactones

Metabolomics

Metabolic Libraries

Lipid Library

Building Blocks

BioChemical

Carbonyl Compounds

Heterocycles, Metabolites & Impurities

Heterocycles

Metabolites & Impurities