METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE

Product Name: METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE
CAS No.: 103606-72-0
Chemical Name: METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE
Synonyms: AKOS PRN-0006;Methyl 2-(3-hydroxyprop-1-yn-1-yl);METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE;ethyl 2-(3-hydroxyprop-1-yn-1-yl)benzoate;Methyl 2-(3-hydroxyprop-1-yn-1-yl)benzoate;Methyl 2-(3-hydroxy-1-propyn-1-yl)benzoate;Benzoic acid, 2-(3-hydroxy-1-propyn-1-yl)-, methyl ester
CBNumber: CB0377865
Molecular Formula: C11H10O3
Formula Weight: 190.2
MOL File: 103606-72-0.mol

More

Less

METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE Property

storage temp.: 2-8°C

More

Less

Safety

Hazard Codes: Xi
Hazard Note: Irritant

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: M323405
Product name: Methyl2-(3-hydroxyprop-1-yn-1-yl)benzoate
Packaging: 250mg
Price: $450
Updated: 2021/12/16

Matrix Scientific

Product number: 075936
Product name: Methyl 2-(3-hydroxyprop-1-yn-1-yl)benzoate
Purity: 95+%
Packaging: 1g
Price: $958
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0030442
Product name: METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE
Purity: 95.00%
Packaging: 250MG
Price: $1066.07
Updated: 2021/12/16

AK Scientific

Product number: X8670
Product name: Methyl2-(3-hydroxyprop-1-ynyl)benzoate
Packaging: 1g
Price: $1343
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0030442
Product name: METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE
Purity: 95.00%
Packaging: 1G
Price: $1630.86
Updated: 2021/12/16

More

Less

METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE Chemical Properties,Usage,Production

Synthesis

610-97-9

107-19-7

103606-72-0

Example 1: Preparation of tert-butoxy-[4-(4-methoxy-3,5-dimethylphenyl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]-acetic acid Step A: Synthesis of methyl 2-(3-hydroxyprop-1-ynyl)-benzoate Methyl 2-iodobenzoate (88.0 g, 335.9 mmol), 2-propyn-1-ol (28.3 g, 503.8 mmol), copper iodide (1.2 g, 6.7 mmol), Pd(PPh3)2Cl2 (7.0 g, 10.0 mmol), and triethylamine (68.0 g, 671.8 mmol) were suspended in acetonitrile (1 L). The solution was bubbled with N2 for 20 min to deoxidize. Subsequently, the reaction mixture was stirred at reflux for 3 h under N2 protection. After completion of the reaction, the mixture was filtered and the filtrate was concentrated to dryness. The residue was purified by column chromatography to afford the target product methyl 2-(3-hydroxyprop-1-ynyl)-benzoate (58.8 g, 92.0% yield). 1H NMR (400 MHz, d6-DMSO): δ 2.48 (t, J = 6.2 Hz, 1H), 3.88 (s, 3H), 4.52 (d, J = 5.6 Hz, 2H), 7.32 (t, J = 7.6 Hz, 1H), 7.41 (t, J = 7.6 Hz, 1H), 7.51 (d, J = 7.6 Hz, 1H), 7.90 (d, J = 7.6 Hz, 1H), 7.90 (d, J = 7.6 Hz, 1H). 7.90 (d, J = 7.2 Hz, 1H).

References

[1] Patent: WO2012/102985, 2012, A1. Location in patent: Page/Page column 94
[2] Doklady Chemistry, 1985, vol. 283, p. 212 - 214
[3] Dokl. Akad. Nauk SSSR Ser. Khim., 1985, vol. 283, # 3, p. 630 - 633
[4] Beilstein Journal of Organic Chemistry, 2014, vol. 10, p. 996 - 1005
[5] Organic Letters, 2018, vol. 20, # 10, p. 3034 - 3038

METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE Suppliers

China 16 Germany 2 India 2 Russia 1 United Kingdom 1 United States 4 Global 26

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Taian Jiaye Biotechnology Co.Ltd

Tel: 13127280945
Email: 285424065@qq.com
Country: China
ProdList: 9976
Advantage: 55

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Sichuan BaiPeng Biotechnology Co., Ltd.

Tel: 028-65791793 18140026355
Fax: QQ568470422
Email: 568470422@qq.com
Country: China
ProdList: 9997
Advantage: 58

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

Suzhou Nuoouman Biological Technology Co., Ltd.

Tel: 15026866316
Email: 180642609@qq.com
Country: China
ProdList: 4967
Advantage: 58

Shanghai alkynechem Co., Ltd.

Tel: 086-021-15821262312 15821262312
Email: info@alkynechem.com
Country: China
ProdList: 1985
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shanghai Pleikon Chemical Technology Co., Ltd

Tel: 021-021-54321516 17717324060
Email: 2719672468@qq.com
Country: China
ProdList: 1880
Advantage: 58

103606-72-0, METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATERelated Search:

Methylparaben METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE 2-ETHYNYLBENZALDEHYDE 2-ETHYNYLTOLUENE 97 2-ETHYNYL-BENZOIC ACID 2-ETHYNYLBENZYL ALCOHOL 97 METHYL 2-(3-HYDROXY-3-METHYL-1-BUTYNYL)BENZOATE METHYL 2-(3-HYDROXY-1-BUTYNYL)BENZOATE

AKOS PRN-0006

ethyl 2-(3-hydroxyprop-1-yn-1-yl)benzoate

Methyl 2-(3-hydroxyprop-1-yn-1-yl)

METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE

Methyl 2-(3-hydroxyprop-1-yn-1-yl)benzoate

Benzoic acid, 2-(3-hydroxy-1-propyn-1-yl)-, methyl ester

Methyl 2-(3-hydroxy-1-propyn-1-yl)benzoate

103606-72-0