FARNESYLPYROPHOSPHATE
- Product Name
- FARNESYLPYROPHOSPHATE
- CAS No.
- 13058-04-3
- Chemical Name
- FARNESYLPYROPHOSPHATE
- Synonyms
- FPP;trans, trans-farnesyl diphosphate;FARNESYL PYROPHOSPHATE AMMONIUM SALT;FPP 3NH3;FPP 3NH4;FARNESYL-PP;FARNESYLDIPHOSPHATE;FARNESYLPYROPHOSPHATE;FARNESYL DIPHOSPHATE-TA;(E,E)-farnesyl diphosphate
- CBNumber
- CB0378488
- Molecular Formula
- C15H28O7P2
- Formula Weight
- 382.33
- MOL File
- 13058-04-3.mol
FARNESYLPYROPHOSPHATE Property
- Melting point:
- >107°C (dec.)
- Boiling point:
- 533.8±60.0 °C(Predicted)
- Density
- 1.233±0.06 g/cm3(Predicted)
- Flash point:
- 11 °C
- storage temp.
- -20°C
- solubility
- Methanol (Slightly, Sonicated), Water (Slightly)
- form
- methanol:ammonia solution
- pka
- 1.07±0.50(Predicted)
- color
- White to Brown
- Stability:
- Hygroscopic, Light Sensitive, Temperature Sensitive
Safety
- Hazard Codes
- F,T
- Risk Statements
- 11-23/24/25-39/23/24/25
- Safety Statements
- 7-16-36/37-45
- RIDADR
- UN 1230 3/PG 2
- WGK Germany
- 1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H370Causes damage to organs
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F6892
- Product name
- Farnesyl pyrophosphate ammonium salt
- Purity
- methanol:ammonia solution, ≥95% (TLC)
- Packaging
- 1vial
- Price
- $105
- Updated
- 2024/03/01
- Product number
- F6892
- Product name
- Farnesyl pyrophosphate ammonium salt
- Purity
- methanol:ammonia solution, ≥95% (TLC)
- Packaging
- 5vials
- Price
- $363
- Updated
- 2024/03/01
- Product number
- 276173
- Product name
- Farnesyl pyrophosphate triammonium salt
- Packaging
- 1mg
- Price
- $698
- Updated
- 2021/12/16
- Product number
- BIO0000460
- Product name
- FARNESYL PYROPHOSPHATE AMMONIUM SALT
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.48
- Updated
- 2021/12/16
FARNESYLPYROPHOSPHATE Chemical Properties,Usage,Production
Uses
Farnesyl pyrophosphate ammonium salt has been used:
- as a prenylation agonist in human osteogenic sarcoma cells in collagen-based cell invasion assays
- in the prenylation of the hepatocyte growth factor (HGF) in human umbilical vein endothelial cells (HUVECs)
- as a substrate in prenyltransferases assay in diatom Haslea ostrearia
Definition
ChEBI: 2-trans,6-trans-farnesyl diphosphate is the trans,trans-stereoisomer of farnesyl diphosphate. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a 2-trans,6-trans-farnesyl diphosphate(3-).
General Description
Farnesyl pyrophosphate is a 15-carbon isoprenoid synthesized from geranyl pyrophosphate (GPP) by the action of enzyme farnesyl pyrophosphate synthase (FPPS).
Biochem/physiol Actions
Farnesyl pyrophosphate (FPP) is the precursor for the biosynthesis of cholesterol, ubiquinone and dolicol. It is part of the intracellular mevalonate pathway. FPP is essential for cell survival and is used for prenylation of several low molecular mass G proteins, including Ras. Inhibition of prenylation results in loss of oncogenic potential of Ras proteins. Inhibition of prenylation may serve as therapeutic potential for management of synaptic plasticity and Alzheimer′s disease.
Purification Methods
Purify the pyrophosphate by chromatography on Whatman No3 MM paper in a system of isopropanol-isobutanol/ammonia/water (40:20:1:30) (v/v). Store it as the Li or NH4 salt at 0o. See geranylgeranyl pyrophosphate below.