ChemicalBook > CAS DataBase List > (Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide

(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide

Product Name
(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide
CAS No.
140405-36-3
Chemical Name
(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide
Synonyms
RSVA 405;RSVA405, 10 mM in DMSO;N'-(4-(Diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide;(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide;2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid;4-Pyridinecarboxylic acid, 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide;RSVA-405,Autophagy,Inhibitor,anti-inflammatory,STAT,AMP-activated protein kinase,disease,Kinase,RSVA405,obesity,Alzheimer's,STAT3,Protein,inhibit,I/R,AMPK,AMP-Activated
CBNumber
CB03921706
Molecular Formula
C17H20N4O2
Formula Weight
312.37
MOL File
140405-36-3.mol
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(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide Property

Density 
1.16±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
<15.62mg/ml in DMSO
pka
8.52±0.40(Predicted)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
5138
Product name
RSVA405
Purity
≥98%(HPLC)
Packaging
10
Price
$183
Updated
2021/12/16
Tocris
Product number
5138
Product name
RSVA405
Purity
≥98%(HPLC)
Packaging
50
Price
$694
Updated
2021/12/16
Usbiological
Product number
256530
Product name
RSVA 405
Packaging
10mg
Price
$438
Updated
2021/12/16
TRC
Product number
R701030
Product name
RSVA405
Packaging
50mg
Price
$755
Updated
2021/12/16
ChemScene
Product number
CS-0026035
Product name
RSVA405
Purity
99.56%
Packaging
100mg
Price
$1150
Updated
2021/12/16
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(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide Chemical Properties,Usage,Production

Uses

RSVA 405 is a potent STAT3 inhibitor and is an analog of resveratol.

in vivo

RSVA405 (3 mg/kg; i.p.) attenuates renal injury and protects renal function after ischemia-reperfusion (I/R) in rats[1].
RSVA405 (20-100 mg/kg/d; p.o. for 11 weeks) significantly reduces the body weight gain of mice fed a high-fat diet[2].

Animal Model:Male Sprague-Dawley rats (300-350 g) are induced I/R injury[1]
Dosage:3 mg/kg
Administration:I.p. one hour before inducing I/R injury
Result:Decreased the levels of creatinine and blood urea nitrogen (BUN), by 35.8% and 44.3% in serum, respectively.
Decreased the levels of aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) by 33.0% and 59.8% in serum, respectively.

IC 50

AMPK: 1 μM (EC50, in cell-based assays)

(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide Suppliers

Canada 1 China 47 United Kingdom 1 United States 4 USA 1 Global 54
Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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Shanghaizehan biopharma technology co., Ltd.
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021-61350663 13052117465
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021-61350662
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sales@zehanbiopharma.com
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China
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Shanghai Beckham Medical Technology Co., Ltd
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13816613772
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QQ: 12922499
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huahero21@sina.com
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China
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2391
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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3008007409@qq.com
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China
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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022-23754520
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klq@cw-bio.com
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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Shanghai Rechem science Co., Ltd.
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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Tianjin heowns Biochemical Technology Co., Ltd.
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400-6387771-6039 18920764717
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Amel Pharmatech Corporation
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027-888-4366503
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China
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5000
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140405-36-3, (Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazideRelated Search:


  • (Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide
  • 2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid
  • RSVA 405
  • RSVA-405,Autophagy,Inhibitor,anti-inflammatory,STAT,AMP-activated protein kinase,disease,Kinase,RSVA405,obesity,Alzheimer's,STAT3,Protein,inhibit,I/R,AMPK,AMP-Activated
  • 4-Pyridinecarboxylic acid, 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide
  • N'-(4-(Diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide
  • RSVA405, 10 mM in DMSO
  • 140405-36-3