Raptinal
- Product Name
- Raptinal
- CAS No.
- 1176-09-6
- Chemical Name
- Raptinal
- Synonyms
- Raptinal;Raptinal, 10 mM in DMSO;[9,9'-Bi-9H-fluorene]-9,9'-dicarboxaldehyde;9H,9'H-[9,9'-Bifluorene]-9,9'-dicarbaldehyde;9H,9'H-[9,9'-Bifluorene]-9,9'-dicarbaldehyde
- CBNumber
- CB03969481
- Molecular Formula
- C28H18O2
- Formula Weight
- 386.44
- MOL File
- 1176-09-6.mol
Raptinal Property
- Melting point:
- 219 °C
- Boiling point:
- 531.3±50.0 °C(Predicted)
- Density
- 1.378±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 33.33 mg/mL (86.25 mM; Need ultrasonic)
- form
- powder to crystal
- color
- White to Almost white
Safety
- HS Code
- 2912.29.6090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1745
- Product name
- Raptinal
- Purity
- ≥95% (HPLC)
- Packaging
- 5 mg
- Price
- $111.15
- Updated
- 2025/07/31
- Product number
- SML1745
- Product name
- Raptinal
- Purity
- ≥95% (HPLC)
- Packaging
- 25 mg
- Price
- $453.15
- Updated
- 2025/07/31
- Product number
- R0199
- Product name
- Raptinal
- Purity
- >96.0%(HPLC)
- Packaging
- 25mg
- Price
- $197
- Updated
- 2025/07/31
- Product number
- R0199
- Product name
- Raptinal
- Purity
- >96.0%(HPLC)
- Packaging
- 100mg
- Price
- $575
- Updated
- 2025/07/31
- Product number
- 42193
- Product name
- Raptinal,≥96%(HPLC)
- Purity
- ≥96%(HPLC)
- Packaging
- 100MG
- Price
- $602.2
- Updated
- 2021/12/16
Raptinal Chemical Properties,Usage,Production
Uses
Raptinal showed complete cytochrome c release within 30 minutes and caspase-3 activation within one hour of exposure (10 μM). Despite its general cytotoxicity in both cancer and non-cancer cell cultures (Cell death induction EC50 = 0.6-3.4 μM in 24 hr), no hematologic toxicity was observed 7 days following single 60 mg/kg i.v. dosing in mice. Studies show th at daily i.p. injection (20 mg/kg) is efficacious in suppressing murine B16-F10 melanoma and 4T1 breast cancer expansion in vivo (by ~60% and 50% in 6 days, respectively).
Biological Activity
Raptinal is a cell-permeable bifluorene-dicarbaldehyde compound th at acts as a rapid activator of mitochondrial pathway-mediated intrinsic apoptosis.
in vivo
Raptinal is an unusually rapid inducer of caspase-dependent apoptosis in multiple cell lines and in vivo systems[1].
Raptinal (20 mg/kg; administered intraperitoneally; once daily for 3 consecutive days for B16-F10 and 4 consecutive days for 4T1 models) exerts anticancer activity in vivo[2].
C57BL/6 mice are administered intravenous Raptinal across a range of dosages as a one-time injection. When administered intravenously at a dosage of 37.5 mg/kg, the peak plasma concentration and elimination half-life of Raptinal are 54.4±0.9 μg/mL and 92.1±5.8 minutes, respectively. Single-dose intravenous Raptinal is well tolerated across a wide dose range (15-60 mg/kg) and does not cause hematologic toxicity as assessed 7 days post-administration[2].
| Animal Model: | C57BL/6 and BALB/c female mice (6-8 weeks old) bearing the B16-F10 model or 4T1 models[2] |
| Dosage: | 20 mg/kg |
| Administration: | Administered intraperitoneally; once daily for 3 consecutive days for B16-F10 and 4 consecutive days for 4T1 models |
| Result: | Retard tumor volume and tumor mass by 60% relative to controls in the B16-F10 model. Similar efficacy was observed for the 4T1 murine breast cancer tumor model with 50% growth inhibition after treatment.? |
IC 50
Caspase 3
Raptinal Preparation Products And Raw materials
Raw materials
Preparation Products
Raptinal Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from Raptinal manufacturers
- Product
- Raptinal 1176-09-6
- Price
- US $1.10-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50kg
- Release date
- 2025-06-23