ChemicalBook > CAS DataBase List > 2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE

2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE

Product Name: 2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE
CAS No.: 70298-89-4
Chemical Name: 2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE
Synonyms: N-(4-Pyridyl)pivalamide;4-(pivaloylamino)pyridine;N-(4-Pyridyl)pivalamide>N-(Pyridin-4-yl)pivalamide;2,2-Dimethyl-N-(4-pyridinyl)propanamid;2,2-Dimethyl-N-pyridin-4-ylpropanamide;2,2-Dimethyl-N-(4-pyridyl)propionamide;2,2-DIMETHYL-N-(4-PYRIDINYL)PROPANAMIDE;Propanamide, 2,2-dimethyl-N-4-pyridinyl-;2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE
CBNumber: CB0404822
Molecular Formula: C10H14N2O
Formula Weight: 178.23
MOL File: 70298-89-4.mol

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2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE Property

Melting point:: 73.9-74.0°C
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
color: White to Almost white
InChI: InChI=1S/C10H14N2O/c1-10(2,3)9(13)12-8-4-6-11-7-5-8/h4-7H,1-3H3,(H,11,12,13)
InChIKey: JCMMVFHXRDNILC-UHFFFAOYSA-N
SMILES: C(NC1C=CN=CC=1)(=O)C(C)(C)C
CAS DataBase Reference: 70298-89-4

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: MNO000019
Product name: 2,2-Dimethyl-N-pyridin-4-yl-propionamide
Purity: Aldrich
Packaging: 1g
Price: $68.1
Updated: 2023/01/07

TCI Chemical

Product number: P2044
Product name: N-(4-Pyridyl)pivalamide
Purity: >98.0%(GC)
Packaging: 1g
Price: $94
Updated: 2024/03/01

TCI Chemical

Product number: P2044
Product name: N-(4-Pyridyl)pivalamide
Purity: >98.0%(GC)
Packaging: 5g
Price: $277
Updated: 2024/03/01

TRC

Product number: D477753
Product name: 2,2-Dimethyl-N-pyridin-4-yl-propionamide
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 018144
Product name: 2,2-Dimethyl-N-pyridin-4-yl-propionamide
Packaging: 5g
Price: $280
Updated: 2021/12/16

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2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Definition

ChEBI: 2,2-Dimethyl-N-(4-pyridinyl)propanamide is a dihydropyridine.

Synthesis

504-24-5

3282-30-2

70298-89-4

a) General procedure for the synthesis of 2,2-dimethyl-N-(pyridin-4-yl)propionamide: 4-Aminopyridine (2 g, 21.3 mmol) was dissolved in dichloromethane (20 ml), to which pentanoyl chloride (3.1 ml, 25.6 mmol) and triethylamine (8.9 ml, 63.9 mmol) were added sequentially dropwise at room temperature. The reaction mixture was stirred at room temperature for 15 h. The reaction was subsequently quenched by addition of water. The organic layer was extracted with ethyl acetate and the combined organic layers were washed with saturated sodium chloride solution (50 ml), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with dichloromethane:methanol (20:1, v/v) as eluent. The fraction containing the target product was collected and concentrated to afford N-(pyridin-4-yl)trimethylacetamide as a white solid (3.6 g, 95% yield).1H-NMR (CDCl3, 300 MHz) data were as follows: δ= 8.47 (d, J = 6.1 Hz, 2H), 7.79 (br s, 1H), 7.52 (d, J = 6.0 Hz, 2H), 7.52 (d, J = 6.0 Hz, 2H). 1.32 (s, 9H).

References

[1] Synthesis, 2009, # 13, p. 2267 - 2277
[2] Patent: US2011/28467, 2011, A1. Location in patent: Page/Page column 16
[3] Chemistry - A European Journal, 2013, vol. 19, # 20, p. 6435 - 6442
[4] Molecules, 2003, vol. 8, # 9, p. 678 - 686
[5] European Journal of Medicinal Chemistry, 2005, vol. 40, # 1, p. 15 - 23

2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE Preparation Products And Raw materials

Raw materials

Hexane Sodium sulfate Triethylamine Pivaloyl chloride Sodium bicarbonate Dichloromethane Methylcyclohexane Magnesium sulfate 4-Aminopyridine

Preparation Products

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2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE Suppliers

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View Lastest Price from 2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE manufacturers

Dideu Industries Group Limited

Product: 2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE 70298-89-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-27

Career Henan Chemical Co

Product: 2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE 70298-89-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

70298-89-4, 2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDERelated Search:

4-[(2,2-DIMETHYLPROPANOYL)AMINO]NICOTINIC ACID 4-(2,2-DIMETHYL-PROPIONYLAMINO)-NICOTINIC ACID METHYL ESTER N-(3-IODO-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE N-(3-FORMYL-4-PYRIDINYL)-2,2-DIMETHYLPROPANAMIDE 2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE N-(3-HYDROXY-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE 2,2-DIMETHYL-N-PYRIDIN-2-YL-PROPIONAMIDE Propionamide (PHENYLCYCLOPENTYL)-N-(4-PYRIDYL)FORMAMIDE N-(3-[1,3]DIOXOLAN-2-YL-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE 2,2-DIMETHYL-N-(3-TRIMETHYLSILANYL-PYRIDIN-4-YL)-PROPIONAMIDE N-(3-TERT-BUTYLSULFANYL-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE N-(3-DIMETHOXYMETHYL-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE 2,2-DIMETHYL-N-PYRIDIN-3-YL-PROPIONAMIDE 3-[4-(2,2-DIMETHYL-PROPIONYLAMINO)-PYRIDIN-3-YL]-ACRYLIC ACID ETHYL ESTER RARECHEM AL BI 1299 RARECHEM AN KA 0922 N-(2-METHYL(4-QUINOLYL))(PHENYLCYCLOPENTYL)FORMAMIDE

2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE

2,2-DIMETHYL-N-(4-PYRIDINYL)PROPANAMIDE

2,2-Dimethyl-N-pyridin-4-ylpropanamide

2,2-Dimethyl-N-(4-pyridinyl)propanamide ,97%

N-(Pyridin-4-yl)pivalamide

4-(2,2,2-TriMethylacetaMido)pyridine, 97%

N-(4-Pyridyl)pivalamide

4-(pivaloylamino)pyridine

N-(4-Pyridyl)pivalamide&gt

2,2-Dimethyl-N-(4-pyridinyl)propanamid

Propanamide, 2,2-dimethyl-N-4-pyridinyl-

2,2-Dimethyl-N-(4-pyridyl)propionamide

2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE ISO 9001：2015 REACH

2,2-Dimethyl-N-pyridin-4-yl- propionamide, 95%

70298-89-4

Amines

Pyridines

API intermediates