3-IODOTHIOPHENE-2-CARBOXYLIC ACID
- Product Name
- 3-IODOTHIOPHENE-2-CARBOXYLIC ACID
- CAS No.
- 60166-84-9
- Chemical Name
- 3-IODOTHIOPHENE-2-CARBOXYLIC ACID
- Synonyms
- 3-IODOTHIOPHENE-2-CARBOXYLIC ACID;2-Thiophenecarboxylic acid, 3-iodo-;4-(3-methoxycarbonyl-5-thiophen-2-yl-1-pyrazolyl)benzoate
- CBNumber
- CB0406523
- Molecular Formula
- C5H3IO2S
- Formula Weight
- 254.05
- MOL File
- 60166-84-9.mol
3-IODOTHIOPHENE-2-CARBOXYLIC ACID Property
- Melting point:
- 195°C
- Boiling point:
- 340.3±27.0 °C(Predicted)
- Density
- 2.238±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 3.10±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 0202BB
- Product name
- 3-Iodothiophene-2-carboxylicAcid
- Packaging
- 100mg
- Price
- $179
- Updated
- 2021/12/16
- Product number
- HCH0022003
- Product name
- 3-IODOTHIOPHENE-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $658.53
- Updated
- 2021/12/16
- Product number
- HCH0022003
- Product name
- 3-IODOTHIOPHENE-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $958.07
- Updated
- 2021/12/16
- Product number
- CD41000715
- Product name
- 3-Iodothiophene-2-carboxylicacid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $144
- Updated
- 2021/12/16
- Product number
- MB-15653
- Product name
- 3-iodothiophene-2-carboxylicacid
- Purity
- 97%
- Packaging
- 25g
- Price
- $680
- Updated
- 2021/12/16
3-IODOTHIOPHENE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis Reference(s)
Tetrahedron Letters, 26, p. 1777, 1985 DOI: 10.1016/S0040-4039(00)98336-9
Synthesis
527-72-0
60166-84-9
Example 1 Preparation of 3-iodothiophene-2-carboxylic acid 1. dissolve thiophene-2-carboxylic acid (12.8 g, 0.1 mol) in THF at -78 °C. 2. n-Butyllithium (88 mL, 2.5 M THF solution, 2.2 eq.) was added slowly dropwise and stirring was continued for 0.5 hr after completion of the drop. 3. THF solution of iodine (28 g, 1.1 eq.) was added slowly with stirring. 4. The reaction mixture was gradually warmed to room temperature and stirred at room temperature until the reaction was complete. 5. The reaction mixture was concentrated to give a crude product. 6. The crude product was dissolved in EtOAc and extracted with 10% aqueous Na2CO3 solution. 7. The aqueous phases were combined and acidified with concentrated hydrochloric acid to pH<2. 8. The acidified aqueous phase was extracted with EtOAc and the organic phases were combined. 9. The organic phase was dried over anhydrous MgSO4, filtered and concentrated in vacuo to give 3-iodothiophene-2-carboxylic acid as a yellow-orange solid (23.5 g, 95% yield). 10. The product was characterized and confirmed by HPLC and mass spectrometry.
References
[1] Patent: WO2005/12311, 2005, A1. Location in patent: Page/Page column 22
[2] Synthetic Communications, 1998, vol. 28, # 13, p. 2467 - 2481
[3] Tetrahedron, 2006, vol. 62, # 41, p. 9554 - 9570
[4] Synlett, 1998, # 1, p. 33 - 34
[5] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985, p. 173 - 182
3-IODOTHIOPHENE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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