ChemicalBook > CAS DataBase List > 3-IODOTHIOPHENE-2-CARBOXYLIC ACID

3-IODOTHIOPHENE-2-CARBOXYLIC ACID

Product Name: 3-IODOTHIOPHENE-2-CARBOXYLIC ACID
CAS No.: 60166-84-9
Chemical Name: 3-IODOTHIOPHENE-2-CARBOXYLIC ACID
Synonyms: 3-IODOTHIOPHENE-2-CARBOXYLIC ACID;2-Thiophenecarboxylic acid, 3-iodo-;4-(3-methoxycarbonyl-5-thiophen-2-yl-1-pyrazolyl)benzoate
CBNumber: CB0406523
Molecular Formula: C5H3IO2S
Formula Weight: 254.05
MOL File: 60166-84-9.mol

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3-IODOTHIOPHENE-2-CARBOXYLIC ACID Property

Melting point:: 195°C
Boiling point:: 340.3±27.0 °C(Predicted)
Density: 2.238±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 3.10±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: 0202BB
Product name: 3-Iodothiophene-2-carboxylicAcid
Packaging: 100mg
Price: $179
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0022003
Product name: 3-IODOTHIOPHENE-2-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 1G
Price: $658.53
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0022003
Product name: 3-IODOTHIOPHENE-2-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5G
Price: $958.07
Updated: 2021/12/16

Crysdot

Product number: CD41000715
Product name: 3-Iodothiophene-2-carboxylicacid
Purity: 95+%
Packaging: 5g
Price: $144
Updated: 2021/12/16

AHH

Product number: MB-15653
Product name: 3-iodothiophene-2-carboxylicacid
Purity: 97%
Packaging: 25g
Price: $680
Updated: 2021/12/16

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3-IODOTHIOPHENE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis Reference(s)

Tetrahedron Letters, 26, p. 1777, 1985 DOI: 10.1016/S0040-4039(00)98336-9

Synthesis

527-72-0

60166-84-9

Example 1 Preparation of 3-iodothiophene-2-carboxylic acid 1. dissolve thiophene-2-carboxylic acid (12.8 g, 0.1 mol) in THF at -78 °C. 2. n-Butyllithium (88 mL, 2.5 M THF solution, 2.2 eq.) was added slowly dropwise and stirring was continued for 0.5 hr after completion of the drop. 3. THF solution of iodine (28 g, 1.1 eq.) was added slowly with stirring. 4. The reaction mixture was gradually warmed to room temperature and stirred at room temperature until the reaction was complete. 5. The reaction mixture was concentrated to give a crude product. 6. The crude product was dissolved in EtOAc and extracted with 10% aqueous Na2CO3 solution. 7. The aqueous phases were combined and acidified with concentrated hydrochloric acid to pH<2. 8. The acidified aqueous phase was extracted with EtOAc and the organic phases were combined. 9. The organic phase was dried over anhydrous MgSO4, filtered and concentrated in vacuo to give 3-iodothiophene-2-carboxylic acid as a yellow-orange solid (23.5 g, 95% yield). 10. The product was characterized and confirmed by HPLC and mass spectrometry.

References

[1] Patent: WO2005/12311, 2005, A1. Location in patent: Page/Page column 22
[2] Synthetic Communications, 1998, vol. 28, # 13, p. 2467 - 2481
[3] Tetrahedron, 2006, vol. 62, # 41, p. 9554 - 9570
[4] Synlett, 1998, # 1, p. 33 - 34
[5] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985, p. 173 - 182

3-IODOTHIOPHENE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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60166-84-9, 3-IODOTHIOPHENE-2-CARBOXYLIC ACIDRelated Search:

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3-IODOTHIOPHENE-2-CARBOXYLIC ACID

4-(3-methoxycarbonyl-5-thiophen-2-yl-1-pyrazolyl)benzoate

2-Thiophenecarboxylic acid, 3-iodo-

60166-84-9

C5H3IO2S