BuforMin Hydrochloride
- Product Name
- BuforMin Hydrochloride
- CAS No.
- 1190-53-0
- Chemical Name
- BuforMin Hydrochloride
- Synonyms
- BUTYL-BIGUANIDE HYDROCHLORIDE;Andere;Adebit;TideMol;Biforon;Sindiatil;PanforMin;Ziavetine;NSC528218;Aids126511
- CBNumber
- CB0407151
- Molecular Formula
- C6H16ClN5
- Formula Weight
- 193.68
- MOL File
- 1190-53-0.mol
BuforMin Hydrochloride Property
- Melting point:
- 177-179?C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 1190-53-0
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B6007
- Product name
- Buformin Hydrochloride
- Packaging
- 50MG
- Price
- $45
- Updated
- 2024/03/01
- Product number
- B6007
- Product name
- Buformin Hydrochloride
- Packaging
- 250MG
- Price
- $154
- Updated
- 2024/03/01
- Product number
- 18507
- Product name
- Buformin (hydrochloride)
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 18507
- Product name
- Buformin (hydrochloride)
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $188
- Updated
- 2024/03/01
- Product number
- 18507
- Product name
- Buformin (hydrochloride)
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $356
- Updated
- 2024/03/01
BuforMin Hydrochloride Chemical Properties,Usage,Production
Description
Buformin is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. It can also deactivate the glycolytic pathway by suppressing glyceraldehyde 3-phosphate dehydrogenase gene expression, which can lead to lactic acidosis. Biguanides, such as buformin, are reported to inhibit the mitochondrial respiratory complex I by inhibiting ubiquinone reduction and by stimulating reactive oxygen species production via the complex I flavin. Some biguanides, including buformin, can also inhibit the mitochondrial ATP synthase. Buformin has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.
Chemical Properties
White Solid
Originator
Silubin,Protochemie,Switz.
Uses
BuforMin Hydrochloride is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. BuforMin Hydrochloride has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.
Uses
Buformin, clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase.
Manufacturing Process
105.6 g of n-butylamine hydrochloride and 79.3 g of dicyandiamide were ground intimately and mixed. The mixture was heated by means of an oil bath, gradually with stirring, and after thirty minutes when the internal temperature had reached 150°C, an exothermic reaction ensued with internal pressure rising to 178°C. The reaction mixture was removed from the oil bath until the internal temperature had fallen to 150°C and then heating was resumed at 150°C for one hour. The cooled fusion mixture was dissolved in 3 liters of acetonitrile and on cooling n-butyl-biguanide hydrochloride precipitated.
Therapeutic Function
Antidiabetic
BuforMin Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BuforMin Hydrochloride manufacturers
- Product
- BuforMin Hydrochloride 1190-53-0
- Price
- US $0.00-0.00/g
- Min. Order
- 10g
- Purity
- 98%Min
- Supply Ability
- 1000kg
- Release date
- 2023-03-15
- Product
- Buformin Hydrochloride 1190-53-0
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ＞98%
- Supply Ability
- 20 tons
- Release date
- 2020-02-10