BuforMin Hydrochloride

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BuforMin Hydrochloride

Product Name: BuforMin Hydrochloride
CAS No.: 1190-53-0
Chemical Name: BuforMin Hydrochloride
Synonyms: BUTYL-BIGUANIDE HYDROCHLORIDE;Andere;Adebit;TideMol;Biforon;Sindiatil;PanforMin;Ziavetine;NSC528218;Aids126511
CBNumber: CB0407151
Molecular Formula: C6H16ClN5
Formula Weight: 193.68
MOL File: 1190-53-0.mol

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BuforMin Hydrochloride Property

Melting point:: 177-179?C
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
CAS DataBase Reference: 1190-53-0

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Safety

Risk Statements: 22-43-36
Safety Statements: 36/39-46
HS Code: 29212900
Toxicity: LD50 i.p. in mice: 380 mg/kg (Rikimaru)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B6007
Product name: Buformin Hydrochloride
Packaging: 50MG
Price: $45
Updated: 2024/03/01

TCI Chemical

Product number: B6007
Product name: Buformin Hydrochloride
Packaging: 250MG
Price: $154
Updated: 2024/03/01

Cayman Chemical

Product number: 18507
Product name: Buformin (hydrochloride)
Purity: ≥95%
Packaging: 100mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 18507
Product name: Buformin (hydrochloride)
Purity: ≥95%
Packaging: 250mg
Price: $188
Updated: 2024/03/01

Cayman Chemical

Product number: 18507
Product name: Buformin (hydrochloride)
Purity: ≥95%
Packaging: 500mg
Price: $356
Updated: 2024/03/01

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BuforMin Hydrochloride Chemical Properties,Usage,Production

Description

Buformin is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. It can also deactivate the glycolytic pathway by suppressing glyceraldehyde 3-phosphate dehydrogenase gene expression, which can lead to lactic acidosis. Biguanides, such as buformin, are reported to inhibit the mitochondrial respiratory complex I by inhibiting ubiquinone reduction and by stimulating reactive oxygen species production via the complex I flavin. Some biguanides, including buformin, can also inhibit the mitochondrial ATP synthase. Buformin has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.

Chemical Properties

White Solid

Originator

Silubin,Protochemie,Switz.

Uses

BuforMin Hydrochloride is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. BuforMin Hydrochloride has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.

Uses

Buformin, clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase.

Manufacturing Process

105.6 g of n-butylamine hydrochloride and 79.3 g of dicyandiamide were ground intimately and mixed. The mixture was heated by means of an oil bath, gradually with stirring, and after thirty minutes when the internal temperature had reached 150°C, an exothermic reaction ensued with internal pressure rising to 178°C. The reaction mixture was removed from the oil bath until the internal temperature had fallen to 150°C and then heating was resumed at 150°C for one hour. The cooled fusion mixture was dissolved in 3 liters of acetonitrile and on cooling n-butyl-biguanide hydrochloride precipitated.

Therapeutic Function

Antidiabetic

BuforMin Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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BuforMin Hydrochloride Suppliers

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View Lastest Price from BuforMin Hydrochloride manufacturers

LY Global chemicals co.,ltd .

Product: BuforMin Hydrochloride 1190-53-0
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 98%Min
Supply Ability: 1000kg
Release date: 2023-03-15

Career Henan Chemical Co

Product: Buformin Hydrochloride 1190-53-0
Price: US $9.80/KG
Min. Order: 1g
Purity: ＞98%
Supply Ability: 20 tons
Release date: 2020-02-10

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Buformin HclQ: What is Buformin Hcl Q: What is the CAS Number of Buformin Hcl Q: What is the storage condition of Buformin Hcl Q: What are the applications of Buformin Hcl

NSC 528218

NSC528218

NSC-528218

agent,Type II diabete,inhibit,Buformin hydrochloride,Inhibitor,SKBR3,cervical cancer,breast cancer,AMPK,biguanide analog,BT474,1-Butylbiguanide,antidiabetic,AMP-activated protein kinase,Buformin

N-Butylbiguanide Hydrochloride v

Buformin hydrochloride >=98% (HPLC)

1190-53-0

C6H16ClN5

C6H15N5HCl

Amines

Intermediates & Fine Chemicals

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