ChemicalBook > CAS DataBase List > 1-PHENYL-2-PROPYN-1-OL

1-PHENYL-2-PROPYN-1-OL

Product Name
1-PHENYL-2-PROPYN-1-OL
CAS No.
4187-87-5
Chemical Name
1-PHENYL-2-PROPYN-1-OL
Synonyms
PHENYLETHYNYLCARBINOL;ETHYNYLPHENYLCARBINOL;Phenylpropynol;Phenyl-2-propy;TIMTEC-BB SBB008986;1-PHENYL-2-PROPYN-1-OL;1-PHENYL-PROP-2-YN-1-OL;1-PHENYL-2-PROPYNE-1-OL;à-ethynylbenzyl alcohol;2-Propyn-1-ol, 1-phenyl-
CBNumber
CB0409973
Molecular Formula
C9H8O
Formula Weight
132.16
MOL File
4187-87-5.mol
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1-PHENYL-2-PROPYN-1-OL Property

Melting point:
22-23 °C(lit.)
Boiling point:
135-136 °C13 mm Hg(lit.)
alpha 
0°(neat)
Density 
1.087 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.549(lit.)
Flash point:
211 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
12.40±0.20(Predicted)
form 
Liquid
Specific Gravity
1.087
color 
Clear yellow
BRN 
742365
InChIKey
UIGLAZDLBZDVBL-UHFFFAOYSA-N
CAS DataBase Reference
4187-87-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
RIDADR 
UN2810
WGK Germany 
3
RTECS 
DO5900000
HazardClass 
6.1
PackingGroup 
III
HS Code 
29062990
Toxicity
mouse,LD50,intraperitoneal,240mg/kg (240mg/kg),Farmaco, Edizione Scientifica. Vol. 8, Pg. 406, 1953.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
226610
Product name
1-Phenyl-2-propyn-1-ol
Purity
98%
Packaging
1g
Price
$24.51
Updated
2025/07/31
Sigma-Aldrich
Product number
226610
Product name
1-Phenyl-2-propyn-1-ol
Purity
98%
Packaging
10g
Price
$186
Updated
2025/07/31
TCI Chemical
Product number
P0220
Product name
1-Phenyl-2-propyn-1-ol
Purity
>98.0%(GC)
Packaging
5g
Price
$70
Updated
2025/07/31
TCI Chemical
Product number
P0220
Product name
1-Phenyl-2-propyn-1-ol
Purity
>98.0%(GC)
Packaging
25g
Price
$267
Updated
2025/07/31
TCI Chemical
Product number
P0220
Product name
1-Phenyl-2-propyn-1-ol
Packaging
1G
Price
$32
Updated
2025/07/31
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1-PHENYL-2-PROPYN-1-OL Chemical Properties,Usage,Production

Chemical Properties

Clear yellow liquid

Synthesis

100-52-7

74-86-2

4187-87-5

The general procedure for the synthesis of (±)-1-phenyl-2-propyn-1-ol from benzaldehyde and acetylene was as follows: magnesium (518 mg, 28.3 mmol) was placed in a pre-flame-dried, two-necked, round-bottomed flask fitted with a reflux condenser and cooled to room temperature under argon atmosphere. Subsequently, tetrahydrofuran (30 mL) and a small amount of iodine crystals were added. Next, a portion of the total volume of n-butyl chloride (2.23 mL, 28.3 mmol) was added dropwise and the mixture was refluxed until the Grignard reagent was generated. After removing the unreacted n-butyl chloride, the remaining n-butyl chloride was added. Stirring was continued at room temperature until all the magnesium was consumed. The reaction mixture was cooled to 0°C and acetylene gas was passed into it over a period of 15 minutes. Subsequently, benzaldehyde (1.0 g, 9.4 mmol) dissolved in tetrahydrofuran (20 mL) was added at 0°C and stirred for 6 hours. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride solution, diluted with water and extracted with ethyl acetate. The organic layers were combined, dried with anhydrous sodium sulfate, concentrated and purified by silica gel column chromatography (eluent 10% petroleum ether solution of ethyl acetate) to afford the target product (±)-1-phenyl-2-propyn-1-ol (1.08 g, 86% yield) as a pale yellow oil.

References

[1] Liebigs Annalen der Chemie, 1982, # 9, p. 1750 - 1752
[2] Organic and Biomolecular Chemistry, 2013, vol. 11, # 35, p. 5954 - 5962
[3] Patent: WO2015/193915, 2015, A1. Location in patent: Page/Page column 11
[4] Liebigs Annalen, 1995, # 7, p. 1353 - 1360
[5] Synthesis, 2004, # 9, p. 1381 - 1390

1-PHENYL-2-PROPYN-1-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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1-PHENYL-2-PROPYN-1-OL Suppliers

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View Lastest Price from 1-PHENYL-2-PROPYN-1-OL manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
1-PHENYL-2-PROPYN-1-OL 4187-87-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-11
Shaanxi Dideu Medichem Co. Ltd
Product
1-PHENYL-2-PROPYN-1-OL 4187-87-5
Price
US $1.00-35.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-07-30
Shanghai Rlavie Technology Co ltd
Product
1-Phenyl-2-propyn-1-ol 4187-87-5
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
100kgs/month
Release date
2021-11-27

4187-87-5, 1-PHENYL-2-PROPYN-1-OLRelated Search:

2-PHENYL-3-BUTYN-2-OL Enpromate 1,1,3-Triphenylpropargyl alcohol 1,1,4,4-TETRAPHENYL-2-BUTYN-1,4-DIOL 1,1-DIPHENYL-2-PROPYN-1-OL 9-ETHYNYL-9-FLUORENOL (-)-1,6-BIS(2-CHLOROPHENYL)-1,6-DIPHENYL-2,4-HEXADIYNE-1,6-DIOL 1-PHENYL-2-PROPYN-1-OL (R)-1-PHENYL-2-PROPYN-1-OL 1-PHENYL-1-PROPYN-3-OL,3-PHENYL-2-PROPYN-1-OL,3-PHENYL-2-PROPYN-1-OL 98+%,2-phenyl-2-propyn-1-ol Propyne Propargyl alcohol 3-PHENYL-1-PROPYNE Butinoline (S)-1-PHENYL-2-PROPYN-1-OL (+)-1,6-BIS(2-CHLOROPHENYL)-1,6-DIPHENYL-2,4-HEXADIYNE-1,6-DIOL 1,1,1-TRIFLUORO-2-PHENYL-3-BUTYN-2-OL 2,4-DIPHENYL-3-BUTYN-2-OL

  • TIMTEC-BB SBB008986
  • PHENYLETHYNYLCARBINOL
  • (+/-)-3-HYDROXY-3-PHENYL-1-PROPYNE
  • (+/-)-ALPHA-ETHYNYLBENZYL ALCOHOL
  • 1-PHENYL-2-PROPYN-1-OL
  • 1-PHENYL-2-PROPYNE-1-OL
  • 1-PHENYL-PROP-2-YN-1-OL
  • 1-PHENYLPROPARGYL ALCOHOL
  • (±)-α-ethynylbenzyl alcohol
  • à-ethynylbenzyl alcohol
  • 1-PHENYL-2-PROPYN-1-OL: TECH., 85%
  • 1-PHENYL-2-PROPYN-1-OL 98%
  • 2-Propyn-1-ol, 1-phenyl-
  • alpha-ethynyl-benzenemethano
  • alpha-ethynylbenzenemethanol
  • alpha-ethynyl-benzylalcoho
  • alpha-Phenylpropargyl alcohol
  • alpha-phenylpropargylalcohol
  • Benzyl alcohol, alpha-ethynyl-
  • ETHYNYLPHENYLCARBINOL
  • A-PHENYLPROPARGYL ALCOHOL
  • Phenylpropynol
  • (±)-α-Ethynylbenzyl alcohol, (±)-1-Phenyl-2-propyn-1-ol, (±)-3-Hydroxy-3-phenyl-1-propyne, 1-Phenylpropargyl alcohol
  • (+/-)-1-PHENYL-2-PROPYN-1-OL, 98+%
  • α-Ethynylbenzenemethanol
  • (§1)-1-Phenyl-2-propyn-1-ol, 98+%
  • Ethynylphenylcarbinol 1-Phenylpropargyl Alcohol
  • Phenyl-2-propy
  • (±)-α-Ethynylbenzyl alcohol, (±)-3-Hydroxy-3-phenyl-1-propyne, 1-Phenylpropargyl alcohol
  • 1-PHENYL-2-PROPYN-1-OL, 98%1-PHENYL-2-PROPYN-1-OL, 98%1-PHENYL-2-PROPYN-1-OL, 98%
  • 1-Phenyl-2-propyn-1-ol&gt
  • Benzenemethanol, α-ethynyl-
  • 1-PHENYL-2-PROPYN-1-OL ISO 9001：2015 REACH
  • (+/-)-1-phenyl-2-propyn-1-ol
  • α-Ethynylbenzenemethanol
  • 4187-87-5
  • CH8801CCHOHC6H5
  • HCCCHOHC6H5
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