ChemicalBook > CAS DataBase List > ATRIAL NATRIURETIC PEPTIDE (126-149) (RAT)

ATRIAL NATRIURETIC PEPTIDE (126-149) (RAT)

Product Name: ATRIAL NATRIURETIC PEPTIDE (126-149) (RAT)
CAS No.: 91421-87-3
Chemical Name: ATRIAL NATRIURETIC PEPTIDE (126-149) (RAT)
Synonyms: rANF 4-27;Auriculin A;ANP (4-27), RAT;AURICULIN A, RAT;ANP (126-149) (RAT);atrialnatriureticfactor(8-33;Auriculin(R) A, rANF 4-27;ATRIAL NATRIURETIC PEPTIDE (126-149);ATRIAL NATRIURETIC PEPTIDE (4-27), RAT;ATRIAL NATRIURETIC PEPTIDE (126-149) (RAT)
CBNumber: CB0410913
Molecular Formula: C104H168N38O33S2
Formula Weight: 2542.81
MOL File: 91421-87-3.mol

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ATRIAL NATRIURETIC PEPTIDE (126-149) (RAT) Property

Density: 1.56
storage temp.: -15°C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PEP0000612
Product name: AURICULIN A
Purity: 95.00%
Packaging: 0.5MG
Price: $710.21
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0000612
Product name: AURICULIN A
Purity: 95.00%
Packaging: 1MG
Price: $884.82
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0000612
Product name: AURICULIN A
Purity: 95.00%
Packaging: 2.5MG
Price: $1091.01
Updated: 2021/12/16

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ATRIAL NATRIURETIC PEPTIDE (126-149) (RAT) Chemical Properties,Usage,Production

Uses

Auriculin A is a synthetic atrial?natriuretic?factor?(ANF) with hemodynamic effect. Auriculin A antagonizes renal vasoconstriction in the dog, and influences on arterial baroreflex control of heart rate, systemic blood pressure, and perfusion pressure in the hind limb (perfused at constant flow) in rabbits[1][2].

in vivo

Auriculin A (0.3 μg/min/kg; i.v.; for 30 min) antagonizes renal vasoconstriction in the dog^[1].
Auriculin A (2 μg/kg prime, 0.2 μg/kg/min; i.v.; for 45 min) influences on arterial baroreflex control of heart rate, systemic blood pressure, and perfusion pressure in the hind limb (perfused at constant flow) in rabbits^[2].

Animal Model:	Female mongrel dogs used in early clamp experiments (15-20 kg, anesthetized with 30 mg/kg pentobarbital sodium i.v.)^[1]
Dosage:	0.3 μg/min/kg
Administration:	Intravenous injection; last for 30 min
Result:	Increased glomerular filtration rate (GFR) 16±4% and Na excretion (UNa V) 261±63%, whereas it decreased urine osmolality (Uosm) 36±7% without changing free water clearance. Also increased diuresis (V) and kaliuresis (UKV).

Animal Model:	New Zealand white male rabbits (3-3.5 kg, anesthetized with 50 mg/kg Chloralose (HY-B1020) and 500 mg/kg Urethane (HY-B1207) i.v.)^[2]
Dosage:	0.5 μg/kg prime, 0.05 μg/kg/min; 2 μg/kg prime, 0.2 μg/kg/min; 4 μg/kg prime, 0.4 μg/kg/min; 8 μg/kg prime, 0.8 μg/kg/min
Administration:	Intravenous injection; last for 30-60 min
Result:	Significantly reduced mean blood pressure and increased mean perfusion pressure at 4 μg/kg prime, 0.4 μg/kg/min dose, while heart rate did not change.

References

[1] Sosa RE, et al. Relationship between renal hemodynamic and natriuretic effects of atrial natriuretic factor. Am J Physiol. 1986 Mar;250(3 Pt 2):F520-4. DOI:10.1152/ajprenal.1986.250.3.F520
[2] Volpe M, et al. Vagal mediation of the effects of atrial natriuretic factor on blood pressure and arterial baroreflexes in the rabbit. Circ Res. 1987 May;60(5):747-55. DOI:10.1161/01.res.60.5.747

ATRIAL NATRIURETIC PEPTIDE (126-149) (RAT) Preparation Products And Raw materials

Raw materials

Preparation Products

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91421-87-3, ATRIAL NATRIURETIC PEPTIDE (126-149) (RAT)Related Search:

GIP (3 - 42), human NEUROPEPTIDE W-30 (HUMAN) H-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2 H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH NEUROPEPTIDE Y (13-36), HUMAN, RAT ADRENOMEDULLIN (26-52) (HUMAN) ALA-ALA-ALA-ALA-ALA N-ALPHA-ACETYL-L-ARGININE L-Arginine acetate AC-ALA-ALA-ALA-ALA-OH AC-DL-ARG-OH 2H2O H-VAL-BETA-ALA-OH AC-ILE-NH2 H-ALA-ARG-OH N-ACETYL-ALA-ALA-ALA AC-ASP-NH2 GLY-GLY-ARG ACETATE SALT AC-GLN-NH2

H-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-ILE-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-OH

AURICULIN A, RAT

ATRIAL NATRIURETIC PEPTIDE (126-149) (RAT)

ATRIAL NATRIURETIC PEPTIDE (4-27), RAT

atrialnatriureticfactor(8-33

atrial natriuretic peptide*fragment 4-27 rat

Auriculin A

ANP (126-149) (RAT)

ANP (4-27), RAT

H-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-OH, (Disulfide bond)

Atrial Natriuretic Peptide, fragment4-27 from rat

Auriculin(R) A, rANF 4-27

ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-ILE-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG(DISULFIDE BRIDGE:CYS4-CYS20)

ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-ILE-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG: RSSCFGGRIDRIGAQSGLGCNSFRDISULFIDE BRIDGE CYS7-CYS23

rANF 4-27

N-L-Arginylatrial natriuretic peptide-23 (rat)

Atrial natriureticpeptide-23 (rat), N-L-arginyl- (9CI)

ATRIAL NATRIURETIC PEPTIDE (126-149)

91421-87-3

91421-78-3

C104H168N38O33S2

Peptide