H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH

Product Name: H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH
CAS No.: 383415-79-0
Chemical Name: H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH
Synonyms: NPW-23 (HUMAN);NEUROPEPTIDE W-23 (HUMAN);Neuropeptide W-23 (human) TFA;Neuropeptide W-23 (huMan) NPW-23 (huMan);Neuropeptide W-23(human),WYKHVASPRYHTVGRAAGL MGL,NPW-23, >95%;TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU;H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH;Neuropeptide W23(human),hypetension,anorexigenic effect,Neuropeptide W 23(human),Neuropeptide W-23 (human),NPW 23,GPR7,Inhibitor,Neuropeptide W,GPR8,NPBW1,NPBW2,inhibit,NPW23;L-Leucine, L-tryptophyl-L-tyrosyl-L-lysyl-L-histidyl-L-valyl-L-alanyl-L-seryl-L-prolyl-L-arginyl-L-tyrosyl-L-histidyl-L-threonyl-L-valylglycyl-L-arginyl-L-alanyl-L-alanylglycyl-L-leucyl-L-leucyl-L-methionylglycyl-
CBNumber: CB3154841
Molecular Formula: C119H183N35O28S
Formula Weight: 2584.01
MOL File: 383415-79-0.mol

More

Less

H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH Property

storage temp.: Desiccate at -20°C
form: Solid
color: White to off-white
Water Solubility: Soluble to 1 mg/ml in sterile water

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Usbiological

Product number: 302085
Product name: Neuropeptide W-23, Human
Packaging: 100ug
Price: $410
Updated: 2021/12/16

ApexBio Technology

Product number: B5361
Product name: Neuropeptide W-23, human
Packaging: 1mg
Price: $347
Updated: 2021/12/16

More

Less

H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH Chemical Properties,Usage,Production

Uses

Neuropeptide W-23 (human) (NPW-23), the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8)[1].

in vivo

Neuropeptide W-23 (human) (NPW-23) (0.3-3.0 nM; intracerebroventricular injection; 2 μL) increases total behavioral activity, including locomotion and grooming in conscious rats^[2].
Neuropeptide W-23 (human) (NPW-23) (2-8 nM; i.c.v.; 10 μL) shows anorexigenic effect in rats^[3].

Animal Model:	Male Harlan Sprague-Dawley rats, 250–300 g^[2]
Dosage:	0.3, 1.0 and 3.0 nM
Administration:	Intracerebroventricular injection, 2 μL
Result:	Caused significant increases in mean arterial pressure. Demonstrated a significant increase in total activity, ambulatory activity, and duration of stereotypy.

Animal Model:	Male Wistar rats weighing 250–300 g^[3]
Dosage:	2, 4, 6 and 8 nM
Administration:	Intra-cerebroventricular injection, 10 μL
Result:	Decreased dark feeding and fasting-induced feeding, decreased feeding intake and weight gain.

References

[1] Ji L, et al. Modulation of CaV1.2 calcium channel by neuropeptide W regulates vascular myogenic tone via G protein-coupled receptor 7. J Hypertens. 2015 Dec;33(12):2431-42. DOI:10.1097/HJH.0000000000000723
[2] Pate AT, et al. Neuropeptide W increases mean arterial pressure as a result of behavioral arousal. Am J Physiol Regul Integr Comp Physiol. 2013 Oct 1;305(7):R804-10. DOI:10.1152/ajpregu.00119.2013
[3] Naso T, et al. Central neuropeptide W has anorexigenic effect in rats. J Anim Physiol Anim Nutr (Berl). 2014 Apr;98(2):228-34. DOI:10.1111/jpn.12067

H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH Suppliers

China 58 Europe 1 France 1 Germany 2 United Kingdom 1 United States 8 USA 1 Global 72

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Cellmano Biotech Limited

Tel: 0551-65326643 18156095617
Fax: 0551-65326641
Email: info@cellmano.com
Country: China
ProdList: 1010
Advantage: 55

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Creative Peptides

Tel
Email: info@creative-peptides.com
Country: United States
ProdList: 6083
Advantage: 56

Nanjing Leon Biological Technology Co., Ltd.

Tel: 17705183659
Fax: 84523390
Email: sales@njleonbiotech.com
Country: China
ProdList: 5501
Advantage: 55

Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

Chengdu Youngshe Chemical Co., Ltd.

Tel: +86-17380623303
Fax: 028-62328193
Email: Caroline@youngshechem.com
Country: China
ProdList: 4802
Advantage: 58

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7408
Advantage: 58

383415-79-0, H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OHRelated Search:

GIP (3 - 42), human ATRIAL NATRIURETIC PEPTIDE (126-149) (RAT) NEUROPEPTIDE W-30 (HUMAN) H-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2 NEUROPEPTIDE Y (13-36), HUMAN, RAT ADRENOMEDULLIN (26-52) (HUMAN) 2,4-PENTANEDIONE, SILVER DERIVATIVE METHYL ISOCYANOACETATE Cupric acetylacetonate Benzyl isocyanide TERT-BUTYL ISOCYANIDE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) SALCOMINE Aluminum acetylacetonate Tris(2,4-pentanedionato)chroMiuM(III) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)

Neuropeptide W-23(human),WYKHVASPRYHTVGRAAGL MGL,NPW-23, >95%

H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH

NPW-23 (HUMAN)

NEUROPEPTIDE W-23 (HUMAN)

TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU

Neuropeptide W-23 (huMan) NPW-23 (huMan)

L-Leucine, L-tryptophyl-L-tyrosyl-L-lysyl-L-histidyl-L-valyl-L-alanyl-L-seryl-L-prolyl-L-arginyl-L-tyrosyl-L-histidyl-L-threonyl-L-valylglycyl-L-arginyl-L-alanyl-L-alanylglycyl-L-leucyl-L-leucyl-L-methionylglycyl-

Neuropeptide W23(human),hypetension,anorexigenic effect,Neuropeptide W 23(human),Neuropeptide W-23 (human),NPW 23,GPR7,Inhibitor,Neuropeptide W,GPR8,NPBW1,NPBW2,inhibit,NPW23

Neuropeptide W-23 (human) TFA

383415-79-0

C119H183N35O28S

Various peptides