5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE

Product Name
5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
CAS No.
493028-20-9
Chemical Name
5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
Synonyms
CBFβ Inhibitor;CBFβ Inhibitor;TIMTEC-BB SBB011699;Runx1-CBFβ interaction inhibitor 1;2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-;CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem;5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE;5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
CBNumber
CB0412427
Molecular Formula
C12H14N2OS
Formula Weight
234.32
MOL File
Mol file
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5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Property

Boiling point:
421.6±40.0 °C(Predicted)
Density 
1.192±0.06 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
DMF: 50 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml
form 
Tan solid
pka
5.00±0.10(Predicted)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16771
Product name
CBFβ Inhibitor
Purity
≥98%
Packaging
5mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
16771
Product name
CBFβ Inhibitor
Purity
≥98%
Packaging
10mg
Price
$135
Updated
2024/03/01
Cayman Chemical
Product number
16771
Product name
CBFβ Inhibitor
Purity
≥98%
Packaging
25mg
Price
$301
Updated
2024/03/01
ApexBio Technology
Product number
C3398
Product name
CBFβInhibitor
Packaging
25mg
Price
$342
Updated
2021/12/16
AK Scientific
Product number
4241AE
Product name
5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine
Packaging
1g
Price
$432
Updated
2021/12/16
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5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Chemical Properties,Usage,Production

Description

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.

Uses

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Suppliers

China 18 France 1 India 1 Russia 1 United States 8 Global 29
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
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65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32112
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58
Aladdin Scientific
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+1-+1(833)-552-7181
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sales@aladdinsci.com
Country
United States
ProdList
52925
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58
ApexBio Technology
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--
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Email
sales@apexbt.com
Country
United States
ProdList
6251
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58
Cayman Chemical Company
Tel
--
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81
Riedel-de Haen AG
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--
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Country
United States
ProdList
6773
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87
Matrix Scientific
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Email
sales@matrixscientific.com
Country
United States
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6632
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TimTec Corporation
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--
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Email
info@timtec.net
Country
United States
ProdList
6891
Advantage
68

493028-20-9, 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINERelated Search:


  • TIMTEC-BB SBB011699
  • 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
  • CBFβ Inhibitor
  • 5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
  • CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem
  • CBFβ Inhibitor
  • 2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-
  • Runx1-CBFβ interaction inhibitor 1
  • 493028-20-9