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2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE

Product Name
2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE
CAS No.
89196-95-2
Chemical Name
2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE
Synonyms
2-BFI HCL;2-BFI HYDROCHLORIDE;RX 801077 hydrochloride;2BFI hydrochloride,2 BFI hydrochloride;2-BFI hydrochlorid (2 BFI hydrochloride;2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE;2-(Benzofuran-2-yl)-2-imidazoline Hydrochloride;2-(Benzofuran-2-yl)-4,5-dihydro-1H-imidazole hydrochloride
CBNumber
CB0414663
Molecular Formula
C11H11ClN2O
Formula Weight
222.67
MOL File
89196-95-2.mol
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2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE Property

storage temp. 
Desiccate at RT
solubility 
DMSO: 20mg/mL, clear
form 
White powder.
color 
White to off-white
Water Solubility 
Soluble to 100 mM in water
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1703
Product name
2-BFI hydrochloride
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$75.2
Updated
2025/07/31
Tocris
Product number
0348
Product name
2-BFIhydrochloride
Packaging
10
Price
$162
Updated
2021/12/16
Tocris
Product number
0348
Product name
2-BFIhydrochloride
Packaging
50
Price
$670
Updated
2021/12/16
TRC
Product number
B203630
Product name
2-(Benzofuran-2-yl)-2-imidazolineHydrochloride
Packaging
100mg
Price
$1010
Updated
2021/12/16
Usbiological
Product number
254354
Product name
2-BFI hydrochloride
Packaging
10mg
Price
$423
Updated
2021/12/16
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2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

2-(Benzofuran-2-yl)-2-imidazoline Hydrochloride is a I2 receptor agonists that induces hypothermic effect in rats.

Biological Activity

High affinity I 2 ligand (K i = 9.8 nM). Putative I 2 agonist; potentiates morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.

in vivo

RX 801077 hydrochloride (5, 10, 20 mg/kg; i.p.; twice daily for 3 days) inhibits NLRP3 inflammasome-induced inflammation and necroptosis in a rat model of traumatic brain injury[2].

Animal Model:280-300 g, Male adult Sprague-Dawley rats (TBI model)[2]
Dosage:5, 10, 20 mg/kg
Administration:I.p.; twice daily for 3 days
Result:Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex.

storage

Desiccate at RT

2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE Suppliers

Canada 1 China 47 Europe 1 Germany 2 Switzerland 2 United Kingdom 2 United States 4 USA 1 Global 60
LucernaChem AG
Tel
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Fax
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Email
lucerna-chem@lucerna-chem.ch
Country
Europe
ProdList
185
Advantage
66

89196-95-2, 2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDERelated Search:

2-Benzofurancarboxamidine 2-FURANCARBOXIMIDAMIDE ETHYL-FURAN-2-YLMETHYL-AMINE BENZOFURAN-2-YLMETHANAMINE 2-FURAN-2-YL-4,5-DIHYDRO-1H-IMIDAZOLE 2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE 2-FURANCARBOXIMIDAMIDE HCL 1-BENZOFURAN-2-YL-N-METHYLMETHANAMINE

  • 2-BFI HCL
  • 2-BFI HYDROCHLORIDE
  • 2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE
  • 2-(Benzofuran-2-yl)-2-imidazoline Hydrochloride
  • 2-BFI hydrochlorid (2 BFI hydrochloride
  • 2BFI hydrochloride,2 BFI hydrochloride
  • RX 801077 hydrochloride
  • 2-(Benzofuran-2-yl)-4,5-dihydro-1H-imidazole hydrochloride
  • 89196-95-2
  • C11H10N2OHCl
  • Imidazoline binding site