2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE
- Product Name
- 2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE
- CAS No.
- 89196-95-2
- Chemical Name
- 2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE
- Synonyms
- 2-BFI HCL;2-BFI HYDROCHLORIDE;RX 801077 hydrochloride;2BFI hydrochloride,2 BFI hydrochloride;2-BFI hydrochlorid (2 BFI hydrochloride;2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE;2-(Benzofuran-2-yl)-2-imidazoline Hydrochloride;2-(Benzofuran-2-yl)-4,5-dihydro-1H-imidazole hydrochloride
- CBNumber
- CB0414663
- Molecular Formula
- C11H11ClN2O
- Formula Weight
- 222.67
- MOL File
- 89196-95-2.mol
2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE Property
- storage temp.
- Desiccate at RT
- solubility
- DMSO: 20mg/mL, clear
- form
- White powder.
- color
- White to off-white
- Water Solubility
- Soluble to 100 mM in water
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1703
- Product name
- 2-BFI hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $75.2
- Updated
- 2025/07/31
- Product number
- 0348
- Product name
- 2-BFIhydrochloride
- Packaging
- 10
- Price
- $162
- Updated
- 2021/12/16
- Product number
- 0348
- Product name
- 2-BFIhydrochloride
- Packaging
- 50
- Price
- $670
- Updated
- 2021/12/16
- Product number
- 254354
- Product name
- 2-BFI hydrochloride
- Packaging
- 10mg
- Price
- $423
- Updated
- 2021/12/16
- Product number
- B203630
- Product name
- 2-(Benzofuran-2-yl)-2-imidazolineHydrochloride
- Packaging
- 100mg
- Price
- $1010
- Updated
- 2021/12/16
2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
2-(Benzofuran-2-yl)-2-imidazoline Hydrochloride is a I2 receptor agonists that induces hypothermic effect in rats.
Biological Activity
High affinity I 2 ligand (K i = 9.8 nM). Putative I 2 agonist; potentiates morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.
in vivo
RX 801077 hydrochloride (5, 10, 20 mg/kg; i.p.; twice daily for 3 days) inhibits NLRP3 inflammasome-induced inflammation and necroptosis in a rat model of traumatic brain injury[2].
| Animal Model: | 280-300 g, Male adult Sprague-Dawley rats (TBI model)[2] |
| Dosage: | 5, 10, 20 mg/kg |
| Administration: | I.p.; twice daily for 3 days |
| Result: | Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex. |
storage
Desiccate at RT
2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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