SUBSTANCE P (6-11)
- Product Name
- SUBSTANCE P (6-11)
- CAS No.
- 51165-07-2
- Chemical Name
- SUBSTANCE P (6-11)
- Synonyms
- QFFGLM-NH2;6-11-Substance P;HEXA-SUBSTANCE P;SUBSTANCE P (6-11);[Gln6]substance P(6-11);GLY-LEU-MET-NH2: GLM-NH2;SUBSTANCE P FRAGMENT 6-11);GLN-PHE-PHE-GLY-LEU-MET-NH2;H-GLN-PHE-PHE-GLY-LEU-MET-NH2;SUBSTANCE-P-(-6-11) HEXA-SUBSTANCE P
- CBNumber
- CB0417745
- Molecular Formula
- C36H52N8O7S
- Formula Weight
- 740.91
- MOL File
- 51165-07-2.mol
SUBSTANCE P (6-11) Property
- storage temp.
- -15°C
N-Bromosuccinimide Price
- Product number
- orb372851
- Product name
- Substance P (6-11)
- Purity
- > 95%
- Packaging
- 1mg
- Price
- $287.3
- Updated
- 2021/12/16
- Product number
- orb372851
- Product name
- Substance P (6-11)
- Purity
- > 95%
- Packaging
- 5mg
- Price
- $552.5
- Updated
- 2021/12/16
- Product number
- PRK0000297
- Product name
- SUBSTANCE P(6-11)
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $617.93
- Updated
- 2021/12/16
- Product number
- orb372851
- Product name
- Substance P (6-11)
- Purity
- > 95%
- Packaging
- 10mg
- Price
- $708.9
- Updated
- 2021/12/16
SUBSTANCE P (6-11) Chemical Properties,Usage,Production
Uses
Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect[1][2].
in vivo
Substance P (6-11) (0.1-10 nM) inhibits insulin and glucagon secretion from the rat pancreas in a dose-dependent manner. In the canine pancreas, by contrast, Substance P (6-11) (1-10 nM), potentiates the release of insulin, glucagon, and somatostatin[2].
References
[1] Y Torrens, et al. Substance P(6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder. Neuropeptides. 1997 Jun;31(3):243-51. DOI:10.1016/s0143-4179(97)90055-x
[2] Y Chiba, et al. Effects of substance P and substance P-(6-11) on hormone release from isolated perfused pancreas: their opposite actions on rat and canine islets. Endocrinology. 1985 Nov;117(5):1996-2000. DOI:10.1210/endo-117-5-1996
SUBSTANCE P (6-11) Preparation Products And Raw materials
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