ChemicalBook > CAS DataBase List > SUBSTANCE P (6-11)

SUBSTANCE P (6-11)

Product Name
SUBSTANCE P (6-11)
CAS No.
51165-07-2
Chemical Name
SUBSTANCE P (6-11)
Synonyms
QFFGLM-NH2;6-11-Substance P;HEXA-SUBSTANCE P;SUBSTANCE P (6-11);[Gln6]substance P(6-11);GLY-LEU-MET-NH2: GLM-NH2;SUBSTANCE P FRAGMENT 6-11);GLN-PHE-PHE-GLY-LEU-MET-NH2;H-GLN-PHE-PHE-GLY-LEU-MET-NH2;SUBSTANCE-P-(-6-11) HEXA-SUBSTANCE P
CBNumber
CB0417745
Molecular Formula
C36H52N8O7S
Formula Weight
740.91
MOL File
51165-07-2.mol
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SUBSTANCE P (6-11) Property

storage temp. 
-15°C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb372851
Product name
Substance P (6-11)
Purity
> 95%
Packaging
1mg
Price
$287.3
Updated
2021/12/16
Biorbyt Ltd
Product number
orb372851
Product name
Substance P (6-11)
Purity
> 95%
Packaging
5mg
Price
$552.5
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PRK0000297
Product name
SUBSTANCE P(6-11)
Purity
95.00%
Packaging
1MG
Price
$617.93
Updated
2021/12/16
Biorbyt Ltd
Product number
orb372851
Product name
Substance P (6-11)
Purity
> 95%
Packaging
10mg
Price
$708.9
Updated
2021/12/16
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SUBSTANCE P (6-11) Chemical Properties,Usage,Production

Uses

Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect[1][2].

in vivo

Substance P (6-11) (0.1-10 nM) inhibits insulin and glucagon secretion from the rat pancreas in a dose-dependent manner. In the canine pancreas, by contrast, Substance P (6-11) (1-10 nM), potentiates the release of insulin, glucagon, and somatostatin[2].

References

[1] Y Torrens, et al. Substance P(6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder. Neuropeptides. 1997 Jun;31(3):243-51. DOI:10.1016/s0143-4179(97)90055-x
[2] Y Chiba, et al. Effects of substance P and substance P-(6-11) on hormone release from isolated perfused pancreas: their opposite actions on rat and canine islets. Endocrinology. 1985 Nov;117(5):1996-2000. DOI:10.1210/endo-117-5-1996

SUBSTANCE P (6-11) Preparation Products And Raw materials

Raw materials

Preparation Products

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