SUBSTANCE P
- Product Name
- SUBSTANCE P
- CAS No.
- 33507-63-0
- Chemical Name
- SUBSTANCE P
- Synonyms
- Sub;TYR8;RPKPQFFGLM;Aids114081;SUBSTANCE P;P substance;Aids-114081;Neurokinin P;RPKPQQFFGLM-NH2;substance P (SP)
- CBNumber
- CB4114260
- Molecular Formula
- C63H98N18O13S
- Formula Weight
- 1347.63
- MOL File
- 33507-63-0.mol
SUBSTANCE P Property
- Melting point:
- 148 °C
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- H2O: 1 mg/mL
- form
- powder
- pka
- 13.26±0.46(Predicted)
- color
- white
- Water Solubility
- Soluble in water, DMSO, and Acetic Acid.
- Sequence
- H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
- InChIKey
- ADNPLDHMAVUMIW-UHFFFAOYSA-N
Safety
- WGK Germany
- 3
- F
- 3-10-21
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 05-23-0600
- Product name
- Substance P - CAS 33507-63-0 - Calbiochem
- Purity
- Neuropeptidefoundinhighconcentrationsinthegut.
- Packaging
- 1mg
- Price
- $69
- Updated
- 2024/03/01
- Product number
- 05-23-0600
- Product name
- Substance P - CAS 33507-63-0 - Calbiochem
- Purity
- Neuropeptide found in high concentrations in the gut.
- Packaging
- 5MG
- Price
- $208
- Updated
- 2024/03/01
- Product number
- 05-23-0600
- Product name
- Substance P - CAS 33507-63-0 - Calbiochem
- Purity
- Neuropeptide found in high concentrations in the gut.
- Packaging
- 25MG
- Price
- $560
- Updated
- 2024/03/01
- Product number
- J63489
- Product name
- Substance P
- Packaging
- 5mg
- Price
- $172
- Updated
- 2023/06/20
- Product number
- J63489
- Product name
- Substance P
- Packaging
- 25mg
- Price
- $675
- Updated
- 2023/06/20
SUBSTANCE P Chemical Properties,Usage,Production
Uses
Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator.
Definition
ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+).
General Description
Substance P is a polypeptide consisting of 11 amino acidresidues. It has been implicated in the transmission of“painful” sensory information through the spinal cord tohigher centers in the central nervous system. Substance Pis localized in the primary afferent sensory fibers. Other pharmacologicaleffects are vasodilatation, stimulation of smoothmuscles, stimulation of salivary secretion, and diuresis. In addition,this neuropeptide contributes to some inflammatory responses.Approximately 50% of the known neuropeptides aresynthesized as biologically inactive glycine extended precursorsthat require a carboxy-terminal posttranslational amidationfor biological activity. Amidation enzymes are responsiblefor the conversion of the carboxyl group of the neuropeptide tothe corresponding amide group and include the two amidatingenzymes peptidylglycine α-monooxygenase (PAM) and peptidylamidoglycolatelyase (PGL), which work sequentially toproduce the inflammatory neuropeptide Substance P from aninactive precursor peptide. Much research is being performedto exploit this mechanism of inflammation.
storage
-20°C
SUBSTANCE P Preparation Products And Raw materials
Raw materials
Preparation Products
SUBSTANCE P Suppliers
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View Lastest Price from SUBSTANCE P manufacturers
- Product
- SUBSTANCE P 33507-63-0
- Price
- US $27.00/box
- Min. Order
- 1box
- Purity
- 99%
- Supply Ability
- 20000box
- Release date
- 2024-04-19
- Product
- SUBSTANCE P 33507-63-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10
- Product
- SUBSTANCE P 33507-63-0
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-16