ChemicalBook > CAS DataBase List > SUBSTANCE P

SUBSTANCE P

Product Name: SUBSTANCE P
CAS No.: 33507-63-0
Chemical Name: SUBSTANCE P
Synonyms: Sub;TYR8;RPKPQFFGLM;Aids114081;SUBSTANCE P;P substance;Aids-114081;SUBSTANCE P;SUBSTANCE P;SUBSTANCE P
CBNumber: CB4114260
Molecular Formula: C63H98N18O13S
Formula Weight: 1347.63
MOL File: 33507-63-0.mol

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SUBSTANCE P Property

Melting point:: 148 °C
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: H₂O: 1 mg/mL
form: powder
pka: 13.26±0.46(Predicted)
color: white
Water Solubility: Soluble in water, DMSO, and Acetic Acid.
Sequence: H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
InChIKey: ADNPLDHMAVUMIW-UHFFFAOYSA-N

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Safety

WGK Germany: 3
F: 3-10-21

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 05-23-0600
Product name: Substance P - CAS 33507-63-0 - Calbiochem
Purity: Neuropeptidefoundinhighconcentrationsinthegut.
Packaging: 1mg
Price: $70.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 05-23-0600
Product name: Substance P - CAS 33507-63-0 - Calbiochem
Purity: Neuropeptide found in high concentrations in the gut.
Packaging: 5MG
Price: $214
Updated: 2025/07/31

Sigma-Aldrich

Product number: 05-23-0600
Product name: Substance P - CAS 33507-63-0 - Calbiochem
Purity: Neuropeptide found in high concentrations in the gut.
Packaging: 25MG
Price: $576
Updated: 2025/07/31

TRC

Product number: S777553
Product name: Substance P
Packaging: 1mg
Price: $45
Updated: 2021/12/16

TRC

Product number: S777553
Product name: Substance P
Packaging: 2.5mg
Price: $90
Updated: 2021/12/16

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SUBSTANCE P Chemical Properties,Usage,Production

Chemical Properties

White freeze-dried powder, soluble in water, high purity aqueous solution is very easy to inactivate, adding tween 80, gelatin, human plasma albumin or bovine gammaglobulin can increase its stability; pH greater than 8 is not stable, inactivated by pepsin and pancreatic curdling protease; it is advisable to be stored in a low pH, and filled with nitrogen or add antioxidants to avoid its inactivation.

Uses

Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator.

Definition

ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+).

General Description

Substance P is a polypeptide consisting of 11 amino acidresidues. It has been implicated in the transmission of“painful” sensory information through the spinal cord tohigher centers in the central nervous system. Substance Pis localized in the primary afferent sensory fibers. Other pharmacologicaleffects are vasodilatation, stimulation of smoothmuscles, stimulation of salivary secretion, and diuresis. In addition,this neuropeptide contributes to some inflammatory responses.Approximately 50% of the known neuropeptides aresynthesized as biologically inactive glycine extended precursorsthat require a carboxy-terminal posttranslational amidationfor biological activity. Amidation enzymes are responsiblefor the conversion of the carboxyl group of the neuropeptide tothe corresponding amide group and include the two amidatingenzymes peptidylglycine α-monooxygenase (PAM) and peptidylamidoglycolatelyase (PGL), which work sequentially toproduce the inflammatory neuropeptide Substance P from aninactive precursor peptide. Much research is being performedto exploit this mechanism of inflammation.

Biological Activity

Cell permeable: no', 'Primary Target
Substance P receptors', 'Product does not compete with ATP.', 'Reversible: no

storage

-20°C

SUBSTANCE P Preparation Products And Raw materials

Raw materials

Electrophoresis

Preparation Products

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SUBSTANCE P Suppliers

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View Lastest Price from SUBSTANCE P manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: SUBSTANCE P 33507-63-0
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-30

Henan Aochuang Chemical Co.,Ltd.

Product: SUBSTANCE P 33507-63-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-10

Shanghai Getian Industrial Co., LTD

Product: SUBSTANCE P 33507-63-0
Price: US $27.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 20000box
Release date: 2024-04-19

33507-63-0, SUBSTANCE PRelated Search:

SUBSTANCE P LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 3ACOH 5H2O GLY-LEU-MET-NH2 SUBSTANCE P (1-7) SUBSTANCE P (2-11) SUBSTANCE P (1-9) ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OME SUBSTANCE P (5-11) SUBSTANCE P (7-11) SUBSTANCE P (4-11) SUBSTANCE P (1-4) PANCREATIC POLYPEPTIDE, RAT SUBSTANCE P (6-11) Substance P (1-7)(TFA) NEUROPEPTIDE Y (13-36), PORCINE SYNTHETI C >97% substance P (3-11) (LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT)

ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2

H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET

H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2

SUBSTANCE P, F & D VERSION OF S6883*ACET ATE

(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide

SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE)

SUBSTANCE P BOVINE

SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11]

SUBSTANCE P (TYR8)

SUBSTANCE P

SUBSTANCE P AMIDE

RPKPQFFGLM

RPKPQQFFGLM-NH2

substance P (SP)

L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2

Substance P,Neurokinin P,Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2,RPKPQQFFGLM-NH2?, >98%

L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-Met-NH2

L-Arg-L-Pro-L-Lys-L-Pro-L-Glu(NH2)-L-Glu(NH2)-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2

Neurokinin P

P substance

Sub

Aids114081

Aids-114081

(S)-N1-((5S,8S,14S,17S,20S)-23-aMino-14,17-dibenzyl-5-carbaMoyl-8-isobutyl-7,10,13,16,19,23-hexaoxo-2-thia-6,9,12,15,18-pentaazatricosan-20-yl)-2-((S)-1-((S)-6-aMino-2-((S)-1-((S)-2-aMino-5-guanidinopentanoyl)pyrrolidine-2-carboxaMido)hexanoyl)pyrrolidine

H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 acetate salt

Substance P TFA salt

Substance P Acetate

TYR8

SUBSTANCE P USP/EP/BP

Substance P，Neurokinin P，Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2，RPKPQQFFGLM-NH2

Substance P (9CI, ACI)

NK receptor,Neurokinin Receptor,Endogenous Metabolite,Substance P,inhibit,Tachykinin receptor,Inhibitor

33507-63-0free/12769-48-1

P substance amide, Neurokinin P Amide

sh-Oligopeptide-73

(S)-2-((S)-1-(L-Arginyl-L-prolyl-L-lysyl)pyrrolidine-2-carboxamido)-N1-((S)-5-amino-1-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)pentanediamide

Substance P, Sensory neuropeptide

Substance P, 10 mM in DMSO

SUBSTANCE P

2-[[2-[[2-[[2-[[2-[[5-Amino-2-[[5-amino-2-[[1-[6-amino-2-[[1-[2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]am ino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpr

Neurokinin P Amide、Substance P

33507-63-0

C63H98N18O13S

C63H98N18O13S1

Tachykinins

Peptides

Biochemicals and Reagents

BioChemical

Agonist

Amino Acids and Peptides

Peptide

Tachykinin receptor

TPI

Peptide Receptors