ChemicalBook > CAS DataBase List > SUBSTANCE P

SUBSTANCE P

Product Name
SUBSTANCE P
CAS No.
33507-63-0
Chemical Name
SUBSTANCE P
Synonyms
Sub;TYR8;RPKPQFFGLM;Aids114081;SUBSTANCE P;P substance;Aids-114081;Neurokinin P;RPKPQQFFGLM-NH2;substance P (SP)
CBNumber
CB4114260
Molecular Formula
C63H98N18O13S
Formula Weight
1347.63
MOL File
33507-63-0.mol
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SUBSTANCE P Property

Melting point:
148 °C
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
H2O: 1 mg/mL
form 
powder
pka
13.26±0.46(Predicted)
color 
white
Water Solubility 
Soluble in water, DMSO, and Acetic Acid.
Sequence
H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
InChIKey
ADNPLDHMAVUMIW-UHFFFAOYSA-N
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Safety

WGK Germany 
3
F 
3-10-21
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
05-23-0600
Product name
Substance P - CAS 33507-63-0 - Calbiochem
Purity
Neuropeptidefoundinhighconcentrationsinthegut.
Packaging
1mg
Price
$69
Updated
2024/03/01
Sigma-Aldrich
Product number
05-23-0600
Product name
Substance P - CAS 33507-63-0 - Calbiochem
Purity
Neuropeptide found in high concentrations in the gut.
Packaging
5MG
Price
$208
Updated
2024/03/01
Sigma-Aldrich
Product number
05-23-0600
Product name
Substance P - CAS 33507-63-0 - Calbiochem
Purity
Neuropeptide found in high concentrations in the gut.
Packaging
25MG
Price
$560
Updated
2024/03/01
Alfa Aesar
Product number
J63489
Product name
Substance P
Packaging
5mg
Price
$172
Updated
2023/06/20
Alfa Aesar
Product number
J63489
Product name
Substance P
Packaging
25mg
Price
$675
Updated
2023/06/20
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SUBSTANCE P Chemical Properties,Usage,Production

Uses

Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator.

Definition

ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+).

General Description

Substance P is a polypeptide consisting of 11 amino acidresidues. It has been implicated in the transmission of“painful” sensory information through the spinal cord tohigher centers in the central nervous system. Substance Pis localized in the primary afferent sensory fibers. Other pharmacologicaleffects are vasodilatation, stimulation of smoothmuscles, stimulation of salivary secretion, and diuresis. In addition,this neuropeptide contributes to some inflammatory responses.Approximately 50% of the known neuropeptides aresynthesized as biologically inactive glycine extended precursorsthat require a carboxy-terminal posttranslational amidationfor biological activity. Amidation enzymes are responsiblefor the conversion of the carboxyl group of the neuropeptide tothe corresponding amide group and include the two amidatingenzymes peptidylglycine α-monooxygenase (PAM) and peptidylamidoglycolatelyase (PGL), which work sequentially toproduce the inflammatory neuropeptide Substance P from aninactive precursor peptide. Much research is being performedto exploit this mechanism of inflammation.

storage

-20°C

SUBSTANCE P Preparation Products And Raw materials

Raw materials

Electrophoresis

Preparation Products

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SUBSTANCE P Suppliers

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View Lastest Price from SUBSTANCE P manufacturers

Shanghai Getian Industrial Co., LTD
Product
SUBSTANCE P 33507-63-0
Price
US $27.00/box
Min. Order
1box
Purity
99%
Supply Ability
20000box
Release date
2024-04-19
Henan Aochuang Chemical Co.,Ltd.
Product
SUBSTANCE P 33507-63-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-10
Career Henan Chemical Co
Product
SUBSTANCE P 33507-63-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-16

33507-63-0, SUBSTANCE PRelated Search:

SUBSTANCE P LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 3ACOH 5H2O GLY-LEU-MET-NH2 SUBSTANCE P (1-7) SUBSTANCE P (2-11) SUBSTANCE P (1-9) ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OME SUBSTANCE P (5-11) SUBSTANCE P (7-11) SUBSTANCE P (4-11) SUBSTANCE P (1-4) PANCREATIC POLYPEPTIDE, RAT SUBSTANCE P (6-11) Substance P (1-7)(TFA) NEUROPEPTIDE Y (13-36), PORCINE SYNTHETI C >97% substance P (3-11) (LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT)

  • ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
  • H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET
  • H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
  • SUBSTANCE P, F & D VERSION OF S6883*ACET ATE
  • (2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide
  • SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE)
  • SUBSTANCE P BOVINE
  • SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11]
  • SUBSTANCE P (TYR8)
  • SUBSTANCE P
  • SUBSTANCE P AMIDE
  • RPKPQFFGLM
  • RPKPQQFFGLM-NH2
  • substance P (SP)
  • L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2
  • Substance P,Neurokinin P,Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2,RPKPQQFFGLM-NH2?, >98%
  • L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-Met-NH2
  • L-Arg-L-Pro-L-Lys-L-Pro-L-Glu(NH2)-L-Glu(NH2)-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2
  • Neurokinin P
  • P substance
  • Sub
  • Aids114081
  • Aids-114081
  • (S)-N1-((5S,8S,14S,17S,20S)-23-aMino-14,17-dibenzyl-5-carbaMoyl-8-isobutyl-7,10,13,16,19,23-hexaoxo-2-thia-6,9,12,15,18-pentaazatricosan-20-yl)-2-((S)-1-((S)-6-aMino-2-((S)-1-((S)-2-aMino-5-guanidinopentanoyl)pyrrolidine-2-carboxaMido)hexanoyl)pyrrolidine
  • H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 acetate salt
  • Substance P TFA salt
  • Substance P Acetate
  • TYR8
  • SUBSTANCE P USP/EP/BP
  • Substance P，Neurokinin P，Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2，RPKPQQFFGLM-NH2
  • Substance P (9CI, ACI)
  • NK receptor,Neurokinin Receptor,Endogenous Metabolite,Substance P,inhibit,Tachykinin receptor,Inhibitor
  • 33507-63-0free/12769-48-1
  • P substance amide, Neurokinin P Amide
  • sh-Oligopeptide-73
  • (S)-2-((S)-1-(L-Arginyl-L-prolyl-L-lysyl)pyrrolidine-2-carboxamido)-N1-((S)-5-amino-1-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)pentanediamide
  • 33507-63-0
  • C63H98N18O13S
  • C63H98N18O13S1
  • Tachykinins
  • Peptides
  • Biochemicals and Reagents
  • BioChemical
  • Agonist
  • Amino Acids and Peptides
  • Peptide
  • Tachykinin receptor
  • TPI
  • Peptide Receptors