SUBSTANCE P

Product Name: SUBSTANCE P
CAS No.: 33507-63-0
Chemical Name: SUBSTANCE P
Synonyms: Sub;TYR8;RPKPQFFGLM;Aids114081;SUBSTANCE P;P substance;Aids-114081;Neurokinin P;RPKPQQFFGLM-NH2;substance P (SP)
CBNumber: CB4114260
Molecular Formula: C63H98N18O13S
Formula Weight: 1347.63
MOL File: 33507-63-0.mol

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SUBSTANCE P Property

Melting point:: 148 °C
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: H₂O: 1 mg/mL
form: powder
pka: 13.26±0.46(Predicted)
color: white
Water Solubility: Soluble in water, DMSO, and Acetic Acid.
Sequence: H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
InChIKey: ADNPLDHMAVUMIW-UHFFFAOYSA-N

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Safety

WGK Germany: 3
F: 3-10-21

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 05-23-0600
Product name: Substance P - CAS 33507-63-0 - Calbiochem
Purity: Neuropeptidefoundinhighconcentrationsinthegut.
Packaging: 1mg
Price: $69
Updated: 2024/03/01

Sigma-Aldrich

Product number: 05-23-0600
Product name: Substance P - CAS 33507-63-0 - Calbiochem
Purity: Neuropeptide found in high concentrations in the gut.
Packaging: 5MG
Price: $208
Updated: 2024/03/01

Sigma-Aldrich

Product number: 05-23-0600
Product name: Substance P - CAS 33507-63-0 - Calbiochem
Purity: Neuropeptide found in high concentrations in the gut.
Packaging: 25MG
Price: $560
Updated: 2024/03/01

Alfa Aesar

Product number: J63489
Product name: Substance P
Packaging: 5mg
Price: $172
Updated: 2023/06/20

Alfa Aesar

Product number: J63489
Product name: Substance P
Packaging: 25mg
Price: $675
Updated: 2023/06/20

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SUBSTANCE P Chemical Properties,Usage,Production

Uses

Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator.

Definition

ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+).

General Description

Substance P is a polypeptide consisting of 11 amino acidresidues. It has been implicated in the transmission of“painful” sensory information through the spinal cord tohigher centers in the central nervous system. Substance Pis localized in the primary afferent sensory fibers. Other pharmacologicaleffects are vasodilatation, stimulation of smoothmuscles, stimulation of salivary secretion, and diuresis. In addition,this neuropeptide contributes to some inflammatory responses.Approximately 50% of the known neuropeptides aresynthesized as biologically inactive glycine extended precursorsthat require a carboxy-terminal posttranslational amidationfor biological activity. Amidation enzymes are responsiblefor the conversion of the carboxyl group of the neuropeptide tothe corresponding amide group and include the two amidatingenzymes peptidylglycine α-monooxygenase (PAM) and peptidylamidoglycolatelyase (PGL), which work sequentially toproduce the inflammatory neuropeptide Substance P from aninactive precursor peptide. Much research is being performedto exploit this mechanism of inflammation.

storage

-20°C

SUBSTANCE P Preparation Products And Raw materials

Raw materials

Electrophoresis

Preparation Products

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SUBSTANCE P Suppliers

China 163 Europe 2 Germany 3 Switzerland 1 United Kingdom 3 United States 13 Global 185

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Fax: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 6968
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 13774214275
Email: zhouzz@univ-bio.com
Country: China
ProdList: 24994
Advantage: 58

Combio (Suzhou) Ltd.

Tel: 0512-51886999 17706251929
Email: office@combiosz.com
Country: China
ProdList: 2981
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Ascent Scientific

Tel: 4401179829988
Fax: 4402030 700 369
Email: customerservice@ascentscientific.co.uk
Country: United Kingdom
ProdList: 279
Advantage: 60

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Cellmano Biotech Limited

Tel: 0551-65326643 18156095617
Fax: 0551-65326641
Email: info@cellmano.com
Country: China
ProdList: 1011
Advantage: 55

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View Lastest Price from SUBSTANCE P manufacturers

Shanghai Getian Industrial Co., LTD

Product: SUBSTANCE P 33507-63-0
Price: US $27.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 20000box
Release date: 2024-04-19

Henan Aochuang Chemical Co.,Ltd.

Product: SUBSTANCE P 33507-63-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-10

Career Henan Chemical Co

Product: SUBSTANCE P 33507-63-0
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

33507-63-0, SUBSTANCE PRelated Search:

SUBSTANCE P LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 3ACOH 5H2O GLY-LEU-MET-NH2 SUBSTANCE P (1-7) SUBSTANCE P (2-11) SUBSTANCE P (1-9) ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OME SUBSTANCE P (5-11) SUBSTANCE P (7-11) SUBSTANCE P (4-11) SUBSTANCE P (1-4) PANCREATIC POLYPEPTIDE, RAT SUBSTANCE P (6-11) Substance P (1-7)(TFA) NEUROPEPTIDE Y (13-36), PORCINE SYNTHETI C >97% substance P (3-11) (LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT)

ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2

H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET

H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2

SUBSTANCE P, F & D VERSION OF S6883*ACET ATE

(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide

SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE)

SUBSTANCE P BOVINE

SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11]

SUBSTANCE P (TYR8)

SUBSTANCE P

SUBSTANCE P AMIDE

RPKPQFFGLM

RPKPQQFFGLM-NH2

substance P (SP)

L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2

Substance P,Neurokinin P,Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2,RPKPQQFFGLM-NH2?, >98%

L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-Met-NH2

L-Arg-L-Pro-L-Lys-L-Pro-L-Glu(NH2)-L-Glu(NH2)-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2

Neurokinin P

P substance

Sub

Aids114081

Aids-114081

(S)-N1-((5S,8S,14S,17S,20S)-23-aMino-14,17-dibenzyl-5-carbaMoyl-8-isobutyl-7,10,13,16,19,23-hexaoxo-2-thia-6,9,12,15,18-pentaazatricosan-20-yl)-2-((S)-1-((S)-6-aMino-2-((S)-1-((S)-2-aMino-5-guanidinopentanoyl)pyrrolidine-2-carboxaMido)hexanoyl)pyrrolidine

H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 acetate salt

Substance P TFA salt

Substance P Acetate

TYR8

SUBSTANCE P USP/EP/BP

Substance P，Neurokinin P，Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2，RPKPQQFFGLM-NH2

Substance P (9CI, ACI)

NK receptor,Neurokinin Receptor,Endogenous Metabolite,Substance P,inhibit,Tachykinin receptor,Inhibitor

33507-63-0free/12769-48-1

P substance amide, Neurokinin P Amide

sh-Oligopeptide-73

(S)-2-((S)-1-(L-Arginyl-L-prolyl-L-lysyl)pyrrolidine-2-carboxamido)-N1-((S)-5-amino-1-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)pentanediamide

33507-63-0

C63H98N18O13S

C63H98N18O13S1

Tachykinins

Peptides

Biochemicals and Reagents

BioChemical

Agonist

Amino Acids and Peptides

Peptide

Tachykinin receptor

TPI

Peptide Receptors