8-BROMO-1,6-NAPHTHYRIDINE
- Product Name
- 8-BROMO-1,6-NAPHTHYRIDINE
- CAS No.
- 17965-74-1
- Chemical Name
- 8-BROMO-1,6-NAPHTHYRIDINE
- Synonyms
- 8-Bromo-1,6phthyridine;8-BROMO-1,6-NAPHTHYRIDINE;1,6-Naphthyridine, 8-bromo-
- CBNumber
- CB0418722
- Molecular Formula
- C8H5BrN2
- Formula Weight
- 209.04
- MOL File
- 17965-74-1.mol
8-BROMO-1,6-NAPHTHYRIDINE Property
- Boiling point:
- 312.0±22.0 °C(Predicted)
- Density
- 1.656±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- pka
- 1.45±0.30(Predicted)
- Appearance
- Off-white to light yellow Solid
- CAS DataBase Reference
- 17965-74-1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B678674
- Product name
- 8-Bromo-1,6-naphthyridine
- Packaging
- 100mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FB13204
- Product name
- 8-Bromo-[1,6]naphthyridine
- Packaging
- 100mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 084150
- Product name
- 8-Bromo-1,6-naphthyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $727
- Updated
- 2021/12/16
- Product number
- HCH0013817
- Product name
- 8-BROMO-1,6-NAPHTHYRIDINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $978.69
- Updated
- 2021/12/16
- Product number
- FB13204
- Product name
- 8-Bromo-[1,6]naphthyridine
- Packaging
- 25mg
- Price
- $65
- Updated
- 2021/12/16
8-BROMO-1,6-NAPHTHYRIDINE Chemical Properties,Usage,Production
Synthesis
253-72-5
17965-74-1
1. Carbon tetrachloride (35 mL) solution of bromine (2.25 mL, 43.7 mmol) was added dropwise to carbon tetrachloride (200 mL) solution of 1,6-naphthyridine (4.73 g, 36.4 mmol) under stirring conditions through a charging funnel. 2. The reaction mixture was heated to reflux for 1 hour. 3. Under reflux conditions, slowly add a dropwise solution of pyridine (2.94 mL, 36.4 mmol) in carbon tetrachloride (30 mL) to the reaction mixture and continue refluxing overnight. 4. Upon completion of the reaction, the reaction mixture was cooled and filtered. 5. Digest the solid with 1 M sodium hydroxide solution (200 mL) for 1 hour. 6. The basic aqueous phase was extracted with dichloromethane (2 x 200 mL), the organic phases were combined, dried over anhydrous sodium sulfate and concentrated. 7. The oil obtained was purified by column chromatography (eluent: 10% ethyl acetate/dichloromethane) to afford 8-bromo-1,6-naphthyridine (2.03 g, 27% yield) as yellow crystals with a melting point of 79-81°C. The solid was extracted with sodium hydroxide solution (2 x 200 mL) for 1 hour.
References
[1] Chemical & Pharmaceutical Bulletin, 1986, vol. 34, # 5, p. 2018 - 2023
[2] Patent: EP1147083, 2004, B1. Location in patent: Page 47
[3] Synthesis, 2007, # 8, p. 1185 - 1196
8-BROMO-1,6-NAPHTHYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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