4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Uses- Product Name
- 4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 479630-08-5
- Chemical Name
- 4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- 4-Piperidinepropanoic aci...;1-Boc-4-(2-Ethoxycarbonyl-acetyl);4-(3-Ethoxy-3-oxopropanoyl)piperidine;BOC-4-(3-ETHOXY-3-OXOPROPAN OYL)PIPERIDINE;1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine;Ethyl 3-Oxo-3-(1-Boc-4-piperidyl)propanoate;N-BOC-4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE;1-Boc-b-oxo-4-piperidinepropanoic acid ethyl ester;4-(3-Ethoxy-3-oxopropanoyl)piperidine, N-BOC protected;N-(T-BUTOXYCARBONYL)-4-(2-ETHOXYCARBONYL-ACETYL) PIPERIDINE
- CBNumber
- CB0419178
- Molecular Formula
- C15H25NO5
- Formula Weight
- 299.36
- MOL File
- 479630-08-5.mol
4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property
- Boiling point:
- 386.1±32.0 °C(Predicted)
- Density
- 1.113±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 10.39±0.20(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 479630-08-5
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B699663
- Product name
- tert-Butyl4-(3-Ethoxy-3-oxopropanoyl)piperidine-1-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- J53674
- Product name
- N-Boc-4-(2-Ethoxycarbonyl-acetyl)-piperidine
- Packaging
- 1g
- Price
- $38
- Updated
- 2021/12/16
- Product number
- 047107
- Product name
- tert-Butyl 4-(3-ethoxy-3-oxopropanoyl)tetrahydro-1(2H)-pyridinecarboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 4H58-1-68
- Product name
- 4-(3-Ethoxy-3-oxopropanoyl)piperidine, N-Boc protected
- Packaging
- 1g
- Price
- $136
- Updated
- 2021/12/16
- Product number
- B012
- Product name
- N-Boc-4-(2-Ethoxycarbonyl-acetyl)-piperidine
- Packaging
- 5g
- Price
- $147
- Updated
- 2021/12/16
4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Uses
N-BOC-4-(2-ethoxycarbonylacetyl)piperidine is a piperidine derivative and an important organic synthesis intermediate with broad application prospects in medicine, scientific research and other fields.
Synthesis
64-17-5
1336874-02-2
479630-08-5
General procedure for the synthesis of tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate from ethanol and compound (CAS:1336874-02-2): tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate (3) was added to anhydrous ethanol (200 mL) and the solution was refluxed for 48 hours. Upon completion of the reaction, the solution was concentrated under vacuum and purified by fast chromatography (eluent: dichloromethane) to afford the product 3 as a slightly reddish oil (14.36 g, 85% yield). The product characterization data were as follows: 1H NMR (500 MHz, CDCl3) δ 12.09 (s, 0.14H, allyl OH), 4.89 (s, 0.14H, allyl CH), 4.13 (q, J = 7Hz, 2H), 4.10-3.96 (m, 2H), 3.42 (s, 2H), 2.81-2.67 (m, 2H), 2.62-2.52 (m, 2H). 2.62-2.52 (m, 1H), 1.85-1.71 (m, 2H), 1.55-1.43 (m, 2H), 1.39 (s, 9H), 1.21 (t, J = 7Hz, 3H); 13C NMR (125 MHz, CDCl3) δ 204.0, 180.2 (alkenols), 172.7 (enol), 167.0, 154.4, 87.52, 79.51, 61.3, 48.5, 47.1, 28.2, 27.1, 13.9; thin-layer chromatography Rf = 0.2 (dichloromethane). High-resolution mass spectrometry (HRMS) calculated value C15H26NO5(M + H)+ 300.1805, measured value 300.1808.
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 20, p. 7193 - 7205
[2] Patent: WO2013/25939, 2013, A2. Location in patent: Page/Page column 69; 71
4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers
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- Product
- 4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 479630-08-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19