Appearance
ChemicalBook > CAS DataBase List > 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester

Appearance
Product Name
4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
CAS No.
206989-61-9
Chemical Name
4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
Synonyms
tert-Butyl 4-acetylpiperidine-1-carboxylate;1-Boc-4-acetyL;N-Boc-4-Acetypiperidine;Zanubrutinib Impurity 6;N-Boc-4-acetylpiperidine;Zanubrutinib impurity-22;1-BOC-4-ACETYL-PIPERIDINE;-N-Boc-4-Acetylpiperidine;1-N-Boc-4-Acetylpiperidine;1-BOC-ESTER4-ACETYL-PIPERIDINE
CBNumber
CB7704363
Molecular Formula
C12H21NO3
Formula Weight
227.3
MOL File
206989-61-9.mol
More
Less

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Property

Boiling point:
312.4±35.0 °C(Predicted)
Density 
1.052±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
-2.23±0.40(Predicted)
form 
solid
Appearance
Colorless to off-white Liquid
InChI
InChI=1S/C12H21NO3/c1-9(14)10-5-7-13(8-6-10)11(15)16-12(2,3)4/h10H,5-8H2,1-4H3
InChIKey
HNVBBNZWMSTMAZ-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(C(C)=O)CC1
More
Less

Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
HazardClass 
IRRITANT
HS Code 
2933399990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SYX00409
Product name
tert-Butyl 4-acetylpiperidine-1-carboxylate
Packaging
1g
Price
$30.7
Updated
2025/07/31
TRC
Product number
T135528
Product name
tert-Butyl 4-acetylpiperidine-1-carboxylate
Packaging
100mg
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
OR321452
Product name
tert-Butyl 4-acetylpiperidine-1-carboxylate
Purity
98%
Packaging
1g
Price
$15
Updated
2021/12/16
Oakwood
Product number
048392
Product name
N-Boc-4-Acetylpiperidine
Purity
98%
Packaging
250mg
Price
$15
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-LS
Product name
N-Boc-4-acetyl piperidine
Packaging
1g
Price
$24
Updated
2021/12/16
More
Less

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Appearance

Light yellow oil

Uses

tert-Butyl 4-Acetylpiperidine-1-carboxylate is a useful research chemical.

Synthesis

Tert-butyl-4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (2.29 g, 8.32 mmol) was dissolved in 30 ml of tetrahydrofuran (THF), and the resulting solution was cooled to -78 °C. To the solution, methylmagnesium bromide (3.0 M) (7.73 ml, 10.82 mmol) was slowly added, and the solution was stirred at 0 °C for 1 hr. After the reaction was completed with a 2 N hydrochloric acid aqueous solution, 6 N sodium hydroxide solution was added to adjust the pH to 10. Then the solution was extracted with dichloromethane. The organic layer was treated with magnesium sulfate (MgSO4) and filtered, and the solution was concentrated. The resulting residue was isolated and purified by silica gel column chromatography (dichloromethane/methanol = 10/1) to give 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester (6.36 g, 94.0 percent).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 4, p. 935 - 939
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 5, p. 1299 - 1305
[3] Patent: EP3255042, 2017, A2. Location in patent: Paragraph 0209; 0212
[4] Patent: WO2008/17461, 2008, A1. Location in patent: Page/Page column 62
[5] Patent: WO2008/42925, 2008, A1. Location in patent: Page/Page column 96

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Suppliers

China 201 Germany 1 India 9 United Kingdom 1 United States 14 Global 226
Sichuan Argalbio Technology Co,.Ltd
Tel
028-028-60651388 13330964498
Email
slyu@hengkangtech.com
Country
China
ProdList
378
Advantage
58
Shanghai Hobor Chemical Co., Ltd
Tel
021-57790084; 13918007836
Fax
021-51685238
Email
sales@hoborchem.com
Country
China
ProdList
392
Advantage
60
Shanghai Kahn Pharmaceutical Co., Ltd.
Tel
021-34979681; 17701870669
Fax
021-34979681
Email
41513101@qq.com
Country
China
ProdList
1785
Advantage
55
Anhui Dexinjia Biopharm Co., Ltd
Tel
0531-82375892 15553111391
Email
3276840968@qq.com
Country
China
ProdList
301
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Tetranov Biopharm
Tel
13526569071
Email
sales@leadmedpharm.com
Country
China
ProdList
7892
Advantage
64
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
More
Less

View Lastest Price from 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Tert-Butyl 4-Acetylpiperidine-1-Carboxylate 206989-61-9
Price
US $1.60-6.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-19
Shaanxi Dideu New Materials Co. Ltd
Product
4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester 206989-61-9
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-15
Career Henan Chemical Co
Product
N-Boc-4-piperidineacetate 206989-61-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
500kg
Release date
2018-08-17

206989-61-9, 4-Acetyl-piperidine-1-carboxylic acid tert-butyl esterRelated Search:

1-Piperidinecarboxylic acid, 4-[3-(dimethylamino)-1-oxo-2-propen-1-yl]-, 1,1-dim Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]- Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)-, (7S)- (R)-Zanubrutinib 4-PHENOXYBENZOIC ACID Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)- Zanubrutinib 1-Boc-hexahydro-1H-azepin-4-amine 1-Boc-4-cyanopiperidine 3-AMINO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-PIPERIDINEACETIC ACID METHYL ESTER tert-butyl 6-hydroxy-3-azabicyclo[3.1.0]hexane-3-carboxylate tert-butyl 4-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate tert-Butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate hydrochloride 2-OXO-2,5-DIHYDRO-PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

  • 4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 1-N-Boc-4-Acetylpiperidine
  • N-Boc-4-acetylpiperidine
  • 1-tert-Butoxycarbonyl-4-acetylpiperidine
  • 1-Piperidinecarboxylic acid, 4-acetyl-, 1,1-dimethylethyl ester
  • 1-BOC-4-ACETYL-PIPERIDINE
  • N-Boc-4-Acetypiperidine
  • tert-Butyl 4-acetylpiperidine-1-carboxylate
  • 1-BOC-ESTER4-ACETYL-PIPERIDINE
  • 4-acetyl-piperidine-1-carboxylic acid Mono t-butyl ester
  • 4-acetyl-1-piperidinecarboxylic acid tert-butyl ester
  • tert-butyl 4-ethanoylpiperidine-1-carboxylate
  • 4-acetyl-1-(t-butoxycarbonyl)piperidine
  • 1-Boc-4-acetyL
  • Zanubrutinib Related Compound 4
  • Zanubrutinib Impurity 6
  • -N-Boc-4-Acetylpiperidine
  • 7-(1-benzoylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
  • Zanubrutinib benzoyl amide impurity
  • Zanubrutinib impurity-22
  • <i>tert</i>-Butyl 4-acetylpiperidine-1-carboxylate
  • 1-(tert-Butoxycarbonyl)piperidin-4-yl methyl ketone
  • 206989-61-9
  • 206979-61-9
  • C12H20NO4