Appearance
ChemicalBook > CAS DataBase List > 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester

Appearance
Product Name
4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
CAS No.
206989-61-9
Chemical Name
4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
Synonyms
tert-Butyl 4-acetylpiperidine-1-carboxylate;1-Boc-4-acetyL;N-Boc-4-Acetypiperidine;Zanubrutinib Impurity 6;N-Boc-4-acetylpiperidine;Zanubrutinib impurity-22;1-BOC-4-ACETYL-PIPERIDINE;-N-Boc-4-Acetylpiperidine;1-N-Boc-4-Acetylpiperidine;1-BOC-ESTER4-ACETYL-PIPERIDINE
CBNumber
CB7704363
Molecular Formula
C12H21NO3
Formula Weight
227.3
MOL File
206989-61-9.mol
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4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Property

Boiling point:
312.4±35.0 °C(Predicted)
Density 
1.052±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
-2.23±0.40(Predicted)
InChI
InChI=1S/C12H21NO3/c1-9(14)10-5-7-13(8-6-10)11(15)16-12(2,3)4/h10H,5-8H2,1-4H3
InChIKey
HNVBBNZWMSTMAZ-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(C(C)=O)CC1
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SYX00409
Product name
tert-Butyl 4-acetylpiperidine-1-carboxylate
Packaging
1g
Price
$29.8
Updated
2024/03/01
TRC
Product number
T135528
Product name
tert-Butyl 4-acetylpiperidine-1-carboxylate
Packaging
100mg
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
OR321452
Product name
tert-Butyl 4-acetylpiperidine-1-carboxylate
Purity
98%
Packaging
1g
Price
$15
Updated
2021/12/16
Oakwood
Product number
048392
Product name
N-Boc-4-Acetylpiperidine
Purity
98%
Packaging
250mg
Price
$15
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-LS
Product name
N-Boc-4-acetyl piperidine
Packaging
1g
Price
$24
Updated
2021/12/16
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4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Appearance

Light yellow oil

Uses

tert-Butyl 4-Acetylpiperidine-1-carboxylate is a useful research chemical.

Synthesis

Tert-butyl-4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (2.29 g, 8.32 mmol) was dissolved in 30 ml of tetrahydrofuran (THF), and the resulting solution was cooled to -78 °C. To the solution, methylmagnesium bromide (3.0 M) (7.73 ml, 10.82 mmol) was slowly added, and the solution was stirred at 0 °C for 1 hr. After the reaction was completed with a 2 N hydrochloric acid aqueous solution, 6 N sodium hydroxide solution was added to adjust the pH to 10. Then the solution was extracted with dichloromethane. The organic layer was treated with magnesium sulfate (MgSO4) and filtered, and the solution was concentrated. The resulting residue was isolated and purified by silica gel column chromatography (dichloromethane/methanol = 10/1) to give 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester (6.36 g, 94.0 percent).

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Suppliers

China 200 Germany 1 India 8 United Kingdom 1 United States 14 Global 224
Sichuan Argalbio Technology Co,.Ltd
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028-028-60651388 13330964498
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China
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China
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J & K SCIENTIFIC LTD.
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Energy Chemical
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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001-617-206-9595
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United States
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View Lastest Price from 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester manufacturers

Career Henan Chemical Co
Product
N-Boc-4-piperidineacetate 206989-61-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
500kg
Release date
2018-08-17

206989-61-9, 4-Acetyl-piperidine-1-carboxylic acid tert-butyl esterRelated Search:

1-Piperidinecarboxylic acid, 4-[3-(dimethylamino)-1-oxo-2-propen-1-yl]-, 1,1-dim Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]- Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)-, (7S)- (R)-Zanubrutinib 4-PHENOXYBENZOIC ACID Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)- Zanubrutinib 1-Boc-hexahydro-1H-azepin-4-amine 1-Boc-4-cyanopiperidine 3-AMINO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-PIPERIDINEACETIC ACID METHYL ESTER tert-butyl 6-hydroxy-3-azabicyclo[3.1.0]hexane-3-carboxylate tert-butyl 4-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate tert-Butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate hydrochloride 2-OXO-2,5-DIHYDRO-PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

  • 4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 1-N-Boc-4-Acetylpiperidine
  • N-Boc-4-acetylpiperidine
  • 1-tert-Butoxycarbonyl-4-acetylpiperidine
  • 1-Piperidinecarboxylic acid, 4-acetyl-, 1,1-dimethylethyl ester
  • 1-BOC-4-ACETYL-PIPERIDINE
  • N-Boc-4-Acetypiperidine
  • tert-Butyl 4-acetylpiperidine-1-carboxylate
  • 1-BOC-ESTER4-ACETYL-PIPERIDINE
  • 4-acetyl-piperidine-1-carboxylic acid Mono t-butyl ester
  • 4-acetyl-1-piperidinecarboxylic acid tert-butyl ester
  • tert-butyl 4-ethanoylpiperidine-1-carboxylate
  • 4-acetyl-1-(t-butoxycarbonyl)piperidine
  • 1-Boc-4-acetyL
  • Zanubrutinib Related Compound 4
  • Zanubrutinib Impurity 6
  • -N-Boc-4-Acetylpiperidine
  • 7-(1-benzoylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
  • Zanubrutinib benzoyl amide impurity
  • Zanubrutinib impurity-22
  • 206989-61-9
  • 206979-61-9
  • C12H20NO4