Zanubrutinib
Binding Mode- Product Name
- Zanubrutinib
- CAS No.
- 1691249-45-2
- Chemical Name
- Zanubrutinib
- Synonyms
- Zebutinib;anubrutinib;Zanubrutinib;Zanubritinib;Zanmubrutinib;Zanubtutinib AP;D5-Zanubrutinib;Zanubrutinib API;The BTK inhibitor;BGB-3111(Zanubrutinib)
- CBNumber
- CB93361383
- Molecular Formula
- C27H29N5O3
- Formula Weight
- 471.55
- MOL File
- 1691249-45-2.mol
Zanubrutinib Property
- Boiling point:
- 713.4±60.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:99.67(Max Conc. mg/mL);211.36(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);21.21(Max Conc. mM)
DMF:PBS (pH 7.2) (1:5):0.16(Max Conc. mg/mL);0.34(Max Conc. mM)
Ethanol:33.33(Max Conc. mg/mL);70.68(Max Conc. mM) - form
- A solid
- pka
- 15.35±0.40(Predicted)
- color
- White to off-white
- InChIKey
- RNOAOAWBMHREKO-QFIPXVFZSA-N
- SMILES
- C12=C(C(N)=O)C(C3=CC=C(OC4=CC=CC=C4)C=C3)=NN1[C@H](C1CCN(C(=O)C=C)CC1)CCN2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 28924
- Product name
- Zanubrutinib
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 28924
- Product name
- Zanubrutinib
- Packaging
- 25mg
- Price
- $965
- Updated
- 2024/03/01
- Product number
- 28924
- Product name
- Zanubrutinib
- Packaging
- 5mg
- Price
- $239
- Updated
- 2024/03/01
- Product number
- 28924
- Product name
- Zanubrutinib
- Packaging
- 10mg
- Price
- $448
- Updated
- 2024/03/01
- Product number
- BZ168474
- Product name
- Zanubrutinib
- Packaging
- 5mg
- Price
- $175
- Updated
- 2021/12/16
Zanubrutinib Chemical Properties,Usage,Production
Binding Mode
The electron density map corresponding to zanubrutinib and Cys481 showed covalent linkage with Cys481. Zanubrutinib forms three critical hydrogen bonds with hinge residues Glu475 and Met477. Compared with the co-crystal structure of ibrutinib with BTK, there is an additional hydrogen bond between the backbone carbonyl oxygen of Met477 and the 4-NH. The terminal phenyl group engages in a T-shape π–π stacking with Phe540, and the pyrazolyl nitrogen interacts with Lys430 via a water bridge. The warhead carbonyl also interacts indirectly with the amide NH of Asn484 via two water molecules. Both zanubrutinib and ibrutinib have a piperidinyl linker; however, they adopt two different binding modes in complex with BTK. In addition, a single crystal X-ray structure of zanubrutinib showed a classic intramolecular H-bond between carboxamide oxygen and the 4-NH, which confirmed the bioisosteric mimicry of the aminopyrimidine ring.
Description
Zanubrutinib, a second-generation BTK inhibitor discovered and developed by BeiGene in China, has been approved by the FDA (in 2019) for treating chronic lymphocytic leukemia (CLL) and certain other indications. Zanubrutinib has lower toxicity and better efficacy than ibrutinib. It is in direct competition with AstraZeneca’s acalabrutinib for the $12 billion blood cancer market currently dominated by the first-in-class BTK inhibitor ibrutinib.
History
Zanubrutinib (BGB-3111) is a highly selective second-generation irreversible BTK inhibitor discovered by BeiGene company, which was approved by U.S. FDA in 2019 with a Brukinsa trade name. In preclinical animal experiments, Zanubrutinib showed good oral bioavailability, higher plasma exposure and more complete target inhibition than Ibrutinib in tissues. Compared with Ibrutinib, Zanubrutinib showed more specific, long-lasting selectivity, fewer off-targets and fewer adverse reactions. It only occasionally causes atrial fibrillation or bleeding events. On January 14, 2019, Zanubrutinib capsules were approved by U.S. FDA for a breaking through treatment certification. In mid-November of the same year, Zanubrutinib capsules were approved for marketing in the United States for the treatment of adult mantle cell lymphoma patients who have received at least one of the previous therapies.
Uses
Zanubrutinib is classified as a Bruton''s tyrosine kinase inhibitor. Zanubrutinib is a medication for the treatment of adults with mantle cell lymphoma.
brand name
BrukinsaTM
General Description
Class: non-receptor tyrosine kinase
Treatment: MCL, MZL, WM
Oral bioavailability = 15%
Elimination half-life = 3.3 h
Protein binding = 94%
target
BTK
Metabolism
Zanubrutinib showed a mean terminal elimination half-life of approximately 2–4 h (160 or 320 mg, QD) and an estimated oral bioavailability of 15%, relative to 3.9% (fasting state) for ibrutinib. Zanubrutinib is primarily eliminated hepatically via CYP3A4, but its metabolites have not been characterized.
Zanubrutinib Preparation Products And Raw materials
Raw materials
Preparation Products
Zanubrutinib Suppliers
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- 0531-88110457; 18954159893
- demi@pharmachemm.com
- Country
- China
- ProdList
- 190
- Advantage
- 58
- Tel
- 0546-5612566 13793982289
- Fax
- 0546-5180666
- lucy@harwaypharma.com
- Country
- China
- ProdList
- 80
- Advantage
- 58
- Tel
- 19066311943
- 815989315@qq.com
- Country
- China
- ProdList
- 797
- Advantage
- 58
- Tel
- 519-88821493 18915891730
- shm@czpharma.com
- Country
- China
- ProdList
- 170
- Advantage
- 58
- Tel
- 18515581800 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
- ProdList
- 9400
- Advantage
- 55
- Tel
- 17702719238 18971495150;
- sales@sun-shinechem.com
- Country
- China
- ProdList
- 1077
- Advantage
- 64
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 0512-65218020 18248732722
- biz@pharmsyn.com
- Country
- China
- ProdList
- 99
- Advantage
- 60
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3239
- Advantage
- 55
View Lastest Price from Zanubrutinib manufacturers
- Product
- Zanubrutinib 1691249-45-2
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 1 ton
- Release date
- 2025-08-28
- Product
- Zanubrutinib 1691249-45-2
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- kg
- Release date
- 2024-05-28
- Product
- Zanubrutinib 1691249-45-2
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-08-09