tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate

Product Name: tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate
CAS No.: 2190506-55-7
Chemical Name: tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate
Synonyms: Zanubrutinib Impurity 9;Zanubrutinib Impurity 2;Zanubrutinib impurity-18;Zanubrutinib acetyl impurity;tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate;7-?(1-?Boc-?4-?piperidyl)?-?2-?(4-?phenoxyphenyl)?pyrazolo[1,?5-?a]?pyrimidine-?3-?carbonitrile;(R)-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide;7-(1-acetylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide;tert-butyl 4-(3-cyano-4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-[3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl]-, 1,1-dimethylethyl ester
CBNumber: CB65442564
Molecular Formula: C29H29N5O3
Formula Weight: 495.57
MOL File: 2190506-55-7.mol

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tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate Property

Density: 1.24±0.1 g/cm3(Predicted)
pka: -1.43±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate Chemical Properties,Usage,Production

Uses

7-?(1-?Boc-?4-?piperidyl)?-?2-?(4-?phenoxyphenyl)?pyrazolo[1,?5-?a]?pyrimidine-?3-?carbonitrile is used as a reagent in the synthesis of Zanubrutinib (BGB-3111), a novel, potent, and selective covalent inhibitor of Bruton''s tyrosine kinase.

tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate Suppliers

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Syncozymes (Shanghai) Co.,Ltd.

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2190506-55-7, tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylateRelated Search:

Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)-, hydrochloride (1:2), (7S)- b,b-Carotene-3,3'-diol, 5,8-epoxy-5,8-dihydro-,(3S,3'R,5R)- Zeaxanthin Impurity 6 Zanubrutinib Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)- 4-PHENOXYBENZOIC ACID 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester (R)-Zanubrutinib Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)-, (7S)- 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]- 1-Piperidinecarboxylic acid, 4-[3-(dimethylamino)-1-oxo-2-propen-1-yl]-, 1,1-dim

tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate

Zanubrutinib Impurity 2

1-Piperidinecarboxylic acid, 4-[3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl]-, 1,1-dimethylethyl ester

Zanubrutinib Impurity 9

7-?(1-?Boc-?4-?piperidyl)?-?2-?(4-?phenoxyphenyl)?pyrazolo[1,?5-?a]?pyrimidine-?3-?carbonitrile

tert-butyl 4-(3-cyano-4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate

Zanubrutinib KSM-III: (tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate)

(R)-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

7-(1-acetylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

Zanubrutinib acetyl impurity

Zanubrutinib impurity-18

2190506-55-7