5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
- Product Name
- 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
- CAS No.
- 330792-70-6
- Chemical Name
- 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
- Synonyms
- IbrutinibN-3;IbrutinibIntermediate4;Ibrutinib intermediate3;Zanubrutinib Impurity 8;Zanubrutinib impurity-20;Ibrutinib intermediates N-3;Zanubrutinib Related Compound 6;3-AMino-4-cyano-5-(4-phenoxyphenyl)pyrazole;3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile;3-amino-5-(4-phenoxyphenyl)-1H-Pyrazole-4-carbonitrile
- CBNumber
- CB62604963
- Molecular Formula
- C16H12N4O
- Formula Weight
- 276.29
- MOL File
- 330792-70-6.mol
5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile Property
- Boiling point:
- 585.3±50.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- refractive index
- 1.699
- Flash point:
- 307.8℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly)
- pka
- 10.83±0.50(Predicted)
- InChI
- InChI=1S/C16H12N4O/c17-10-14-15(19-20-16(14)18)11-6-8-13(9-7-11)21-12-4-2-1-3-5-12/h1-9H,(H3,18,19,20)
- InChIKey
- HNIMEQCLCNSCGH-UHFFFAOYSA-N
- SMILES
- N1C(C2=CC=C(OC3=CC=CC=C3)C=C2)=C(C#N)C(N)=N1
- LogP
- 3.25298
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A603990
- Product name
- 3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole
- Packaging
- 100mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- A603990
- Product name
- 3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole
- Packaging
- 1g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- CHM0390612
- Product name
- 5-AMINO-3-(4-PHENOXYPHENYL)-1H-PYRAZOLE-4-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.69
- Updated
- 2021/12/16
- Product number
- CS-M2596
- Product name
- 1H-Pyrazole-4-carbonitrile,3-amino-5-(4-phenoxyphenyl)-
- Purity
- 99.89%
- Packaging
- 10g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- CS-M2596
- Product name
- 1H-Pyrazole-4-carbonitrile,3-amino-5-(4-phenoxyphenyl)-
- Purity
- 99.89%
- Packaging
- 25g
- Price
- $340
- Updated
- 2021/12/16
5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile Chemical Properties,Usage,Production
Chemical Properties
Light yellow to off-white powder.
Uses
3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole has been used as a reactant in the preparation of ring-fused pyrazole derivatives to be used a inhibitors of lymphocyte-specific kinase (Lck)
Application
5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile is an intermediate of Ibrutinib (PCI-32765). it is a heterocyclic intermediate that typically used in the preparation of ACP-196, a selective second-generation BTK inhibitor.
5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile manufacturers
- Product
- 5-Amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile 330792-70-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-28
- Product
- 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile 330792-70-6
- Price
- US $10.00-3.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-29
- Product
- 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile 330792-70-6
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-07-30