(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride

Product Name: (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride
CAS No.: 171752-68-4
Chemical Name: (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride
Synonyms: methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate,hydrochloride;Methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride;TDF-DA-M1;Tadalafile N-2;CHEMPACIFIC 51475;Tetrahydrocarbaline;Aliskiren Impurity 65;Tadalafil Impurity 1 HCl;TadalafilCis-intermediate;Tadalafil Impurity 16 HCl
CBNumber: CB0840958
Molecular Formula: C20H19ClN2O4
Formula Weight: 386.82886
MOL File: 171752-68-4.mol

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(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Property

Melting point:: 239-241 °C
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly, Sonicated), Methanol (Slightly)
form: Solid
color: Off-White to Pale Yellow
Stability:: Hygroscopic
InChI: InChI=1/C20H18N2O4.ClH/c1-24-20(23)15-9-13-12-4-2-3-5-14(12)21-19(13)18(22-15)11-6-7-16-17(8-11)26-10-25-16;/h2-8,15,18,21-22H,9-10H2,1H3;1H/t15-,18-;/s3
InChIKey: ROYJOKDTCKPQHK-QHWQFTOMNA-N
SMILES: C12[C@@H](C3=CC=C4OCOC4=C3)N[C@H](CC=1C1C(=CC=CC=1)N2)C(OC)=O.Cl |&1:1,12,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 7843CS
Product name: Methyl(1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate;hydrochloride
Packaging: 5g
Price: $76
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0000858
Product name: (1R,3R)-1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $496.53
Updated: 2021/12/16

Ambeed

Product number: A594987
Product name: (1R,3R)-Methyl1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylatehydrochloride
Purity: 98%
Packaging: 100g
Price: $114
Updated: 2021/12/16

Ambeed

Product number: A1472715
Product name: (1R,3R)-Methyl1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylatehydrochloride
Purity: 97%+(HPLC)
Packaging: 100g
Price: $114
Updated: 2021/12/16

Crysdot

Product number: CD11233784
Product name: (1R,3R)-Methyl1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylatehydrochloride
Purity: 98%
Packaging: 100g
Price: $128
Updated: 2021/12/16

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(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Chemical Properties,Usage,Production

Preparation

D-tryptophan methyl ester hydrochloride and piperonal chloride dissolved in redistilled tetrahydrofuran and then added trifluoroacetic acid. Stir the reaction at 30 ° C for 10 h under the protection of nitrogen. Add sodium triacetoxyborohydride and continue the reaction for 3 hours. After the reaction is monitored by a TLC plate, the reaction solution is concentrated to about 10 mL, deionized water is added, and extracted with ethyl acetate twice. Saturated sodium chloride was washed twice, and dried under reduced pressure to obtain (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride. The yield was 86.95%, the purity was 98.76%.

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Suppliers

China 228 India 5 United States 8 Global 241

Tianjin Chenrui Technology Co., Ltd.

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JinanGongchuang Pharmaceutical Technology Co. Ltd..

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ShenZhen H&D Pharmaceutical Technology Co., LTD

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Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
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Adamas Reagent, Ltd.

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Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
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Nanjing Chemlin Chemical Co., Ltd

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View Lastest Price from (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: (1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, HYDROCHLORIDE 171752-68-4
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99% HPLC
Supply Ability: 1000
Release date: 2024-10-30

hebei hongtan Biotechnology Co., Ltd

Product: Tadalafil intermediate 171752-68-4
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000kg
Release date: 2024-05-13

Apeloa production Co.,Limited

Product: hydrochloride 171752-68-4
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1000
Release date: 2024-05-15

171752-68-4, (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochlorideRelated Search:

BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE] cis-ent-Tadalafil cis-Tadalafil 5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (S)-1-Boc-3-hydroxypiperidine Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Trelagliptin succinate Tadalafil Hydroxytyrosol Benoxinate Hydrochloride Chloropretadalafil D-Tryptophan methyl ester hydrochloride (1S,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester Tadalafil EP IMpurity G Tadalafil Impurity 11 Tadalafil Impurity 39 Tadalafil Impurity 62

INTERMEDIATES OF TADALAFIL:(1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, CIS ISOMER, HYDROCHLORIDE

[171596-44-4], C20H18N2O4,350.13

1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-

1H-Pyrido[3,4-b]indole-3-carboxylicacid

methylester, monohydrochloride, (1R,3R)-

(1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, HYDROCHLORIDE

CHEMPACIFIC 51475

cis-(1R,3R)-1,2,3,4-Tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride

(1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro- 1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride

(1R, 3R)-9H-PYRIDO[3,4-B] INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1- (3,4-METHYLENDIOXYPHENYL), METHYL ESTER, HYDROCHLORIDE

(1R,3R)-1-BENZO[1,3]DIOXOL-5-YL-2,3,4,9-TETRAHYDRO-1H-Β-CARBOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE

1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-, methyl ester, hydrochloride (1:1), (1R,3R)

methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate,hydrochloride

(1R,3R)-9h-pyrido[3,4-b]indole-3-carboxylicacid,1,2,3,4 -tetrahydro-1-(3,4-methylenedioxyphenyl), methyl ester, hydrochloride(Tadalafil Intermediates)

(1R,3R)-9H-Pyrido[3,4-B]Indol-3-Carboxylic Acid 1,2,3,4-Terahydro-1-(3,4-Methylendioxyphenyl),Methyl Ester Hydrochloride

(1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, HYDROCHLORID

(1R,3R)-1,2,3,4-Tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride

Tadalafil Impurity 1 HCl

Methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride

cis-(1r,3r)-1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9h-pyrido(3,4-b)indole-3-carboxylic acid methyl ester

cis-(1R,3R)-1,2,3,4-Tetrahydro-1-(3,4-methylenedioxyphenyl) -9H-pyrido[3,4-b]indole-3-carboxy

cis-(1R,3R)-1,2,3,4-Tetrah

Tadalafil impurity 20/methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride

(1R,3R)-9H-pyrido[3,4-B]indole-3-carboxylic

Tadalafil intermediate-API

(1R,3R)-METHYL 1-(BENZO[D][1,3]DIOXOL-5-YL)-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLATE HCL

cis-1,2,3,4-Tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride

(1R, 3R) -9H-pyridyl [3,4-B] indole-3-carboxylic acid, (1R, 3R) -9H-pyridyl [3,4-B] indole-3-carboxylic acid, 1,2,3, 4-tetrahydro-1 - (3, 4-methylene dioxyphenyl),

Tadalafil intermediates，(1R,3R)-9H-pyrido[3,4-B]indole-3- carboxylic acid, 1,2,3,4-tetrahydro-1- (3,4-methylenedioxyphenyl), methyl ester, hydrochloride

Tadalafile N-2

(1R,3R)-9H-pyrido[3,4-B]indole-3-carboxylic acid, 1,2,3,4-te...

Intermediate of Tadalafil 2

(1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, HYDROCHLORIDE

methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1

1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL)

(1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride (1:1)

(1R3R)-9H-PYRIDO[3.4-BJINDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3.4-METHYLENEDIOXYPH ENYL)

Tetrahydrocarbaline

Cis - (1R, 3R) -1,2,3,4-tetrahydro-1- (3,4-methylenedioxyphenyl) -9H pyridino [3,4-B] indole-3-carboxylic acid methyl ester hydrochloride

TDF-DA-M1

TadalafilCis-intermediate

Tadalafil Impurity 16 HCl

Aliskiren Impurity 65

Tadalafil Impurity 22 HCl

171752-68-4

17152-68-4

C20H18N2O4HCl

Intermediate of Tadalafil