(S)-1-Boc-3-hydroxypiperidine

Uses

Product Name: (S)-1-Boc-3-hydroxypiperidine
CAS No.: 143900-44-1
Chemical Name: (S)-1-Boc-3-hydroxypiperidine
Synonyms: tert-butyl (S)-3-hydroxypiperidine-1-carboxylate;(S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;Ibrutinib Interm 0441;CAS:143900-44-1;1,1-DiMethylethy;(S)-BOC-piperidinol;Ilutinib impurity 7;(S)-1-BOC-3-PIPERIDINOL;（S）-N-BOC-3-piperidinol;(S)-1-BOC-Piperidin-3-ol
CBNumber: CB6197360
Molecular Formula: C10H19NO3
Formula Weight: 201.26
MOL File: 143900-44-1.mol

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(S)-1-Boc-3-hydroxypiperidine Property

Melting point:: 34-40 °C
Boiling point:: 292.3±33.0 °C(Predicted)
Density: 1.107±0.06 g/cm3(Predicted)
Flash point:: 110 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in methanol.
pka: 14.74±0.20(Predicted)
form: Powder or Crystalline Powder
color: White to tan
optical activity: [α]22/D +10.0°, c = 1 in chloroform
InChI: InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m0/s1
InChIKey: UIJXHKXIOCDSEB-QMMMGPOBSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC[C@H](O)C1
CAS DataBase Reference: 143900-44-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
HS Code: 29339900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 687367
Product name: (S)-1-Boc-3-hydroxypiperidine
Purity: 97%
Packaging: 1g
Price: $115
Updated: 2025/07/31

TCI Chemical

Product number: B4446
Product name: (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
Purity: >98.0%(GC)
Packaging: 1g
Price: $21
Updated: 2025/07/31

TCI Chemical

Product number: B4446
Product name: (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $64
Updated: 2025/07/31

TRC

Product number: B656650
Product name: (S)-1-Boc-3-hydroxypiperidine
Packaging: 50g
Price: $200
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK994833
Product name: (S)-1-Boc-3-hydroxypiperidine
Purity: 97%
Packaging: 5g
Price: $225
Updated: 2021/12/16

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(S)-1-Boc-3-hydroxypiperidine Chemical Properties,Usage,Production

Uses

(S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma.

Description

(S)-1-Boc-3-hydroxypiperidine, alias (S)-N-Boc-3-hydroxypiperidine (S-NBHP) is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies.S-NBHP can be prepared in a variety of ways such as chemically or biocatalytically. S-NBHP can be prepared in various ways, such as chemical synthesis or biocatalysis. Biocatalysis is an efficient process for the reduction of N-Boc-piperidin-3-one by recombinant keto reductase (KRED) catalytic to obtain optically pure S-NBHP using 99% yield. The asymmetric reduction of N-Boc-piperidin-3-one (NBPO) to (S)-NBHP can also be catalysed by a reductase (YDR541C) isolated from Saccharomyces cerevisiae in 99% yield.

Chemical Properties

White powder

Uses

(S)-1-Boc-3-hydroxypiperidine is used as pharmaceutical intermediate.

Uses

A piperidine derivative with an amine protecting group, (S)-1-Boc-3-hydroxypiperidine can be used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase.

(S)-1-Boc-3-hydroxypiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-Boc-3-hydroxypiperidine Suppliers

Americas 1 Canada 1 China 516 Europe 3 Germany 5 India 21 Japan 3 Switzerland 2 United Kingdom 16 United States 49 Global 617

Suzhou lipin Chemical Co., Ltd

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View Lastest Price from (S)-1-Boc-3-hydroxypiperidine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: (S)-1-Boc-3-hydroxypiperidine 143900-44-1
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-12-06

Henan Aochuang Chemical Co.,Ltd.

Product: (S)-1-Boc-3-hydroxypiperidine 143900-44-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-13

Shaanxi Dideu New Materials Co. Ltd

Product: (S)-1-Boc-3-hydroxypiperidine 143900-44-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2024-11-13

143900-44-1, (S)-1-Boc-3-hydroxypiperidineRelated Search:

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Ibrutinib Interm 0441

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Ilutinib impurity 7

CAS:143900-44-1

(<i>S</i>)-1-Boc-3-hydroxypiperidine

(S)-1-(tert-Butoxycarbonyl)-3-carboxypiperidine

tert-butyl (S)-3-hydroxypiperidine-1-carboxylate (Intermediate of Ibrutinib)

143900-44-1

14390-44-1

43900-44-1

C10H19NO3HCl

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